Bibliometric and visual analysis of mesenchymal stem cells in the treatment of osteoporosis based on CiteSpace software

Abstract

Background: The focus of research in the treatment of osteoporosis (OP) has evolved from promoting bone formation and inhibiting bone resorption to current stem cell therapy. Due to their multipotent differentiation properties, mesenchymal stem cells (MSCs) can repair degenerated bones through transplantation, and have become a new method for the treatment of OP. Methods: Relevant literatures included in the Web of Science database core collection database from 2012 to 2021 were retrieved. CiteSpace software was used to analyze the cooperative relationship among authors, journals, institutions, and countries, and to analyze the co-citation situation of the literature. And performed co-occurrence analysis, cluster analysis and burst analysis of keywords, draw visual maps and analyzed the results. Results: A total of 2100 papers were included, and the number of papers published from 2012 to 2021 was on the rise. A total of 484 authors were included, and 176 authors published more than 3 papers. The high-yield authors were mainly represented by YAN JIN and BO GAO. A total of 99 journals were included, and the journal with the most publications was J BONE MINER RES. A total of 787 institutions were included, and the institution with the largest number of publications was Shanghai Jiao Tong University. A total of 65 countries were included. The country with the largest number of publications was China, and the United States had the highest centrality. The co-citation analysis of the literature found 2 articles with high citation frequency and high centrality. The main research direction was the mechanism of MSCs in the treatment of osteoporosis. A total of 133 keywords were included, and the hot keywords were osteogenic differentiation, expression, proliferation, bone marrow, etc. Conclusions: The research hotspots in this field mainly focused on the mechanism of bone regeneration, proliferation and osteogenic differentiation of bone marrow MSCs, and the expression of osteogenic-related genes. The future research trends in this field are predicted to be the mechanism of action of microRNA and long non-coding RNA on MSCs and their relationship with OP, the mechanism of MSCs adipogenic and osteogenic differentiation, and tissue engineering scaffolds applications.

Global Trends and Future Research Directions for Temporomandibular Disorders and Stem Cells

“…In the present study, the country that most published on the subject was China, which accounted for 61 published articles, reinforcing the result of other bibliometric studies on stem cells, in which China also ranked first with 1247 and 899 articles published, respectively [ 25 , 26 ]. Also, the USA obtained second place in these same studies, with 392 and 278 articles published, respectively.…”

“…Interestingly, this was the period in which there were more publications on the subject, and the articles in which the authors shared authorship obtained a more significant number of quotes. As our study is about a specific theme, TMD and stem cells, when we compare our results with other bibliometric studies on each of these themes individually [ 23 , 24 , 25 , 26 ], the results are different, and several other authors appear. This is probably because the themes are very broad and cover classic studies, which have great impact, and were cited many times, serving as a basis and guideline to determine clinical conducts or even research protocols.…”

“…It was observed that they worked with the theme in general, sometimes selecting the most cited articles in each period. Bibliometric studies on stem cells were also found; however, these studies were focused on the mechanisms of action, characteristics, differentiation, and cell signaling [ 25 , 26 ].…”