Bibliometric and visual analysis of neutrophil extracellular traps from 2004 to 2022

Abstract

BackgroundNeutrophil extracellular traps (NETs) are specialized structures formed by neutrophils that were initially found to be important in killing pathogenic bacteria during infection. With the development of related research, the relationship between NETs and diseases such as sepsis, cancer, and systemic lupus erythematosus has received close attention. However, there is a lack of reports that comprehensively and objectively present the current status of NETs-related studies. Therefore, this study aims to visually analyze the current status and trends of NETs-related research by means of bibliometrics and knowledge mapping.MethodsNETs-related articles and reviews were retrieved using the Web of Science core collection subject search, and bibliometric analysis was performed in Excel 365, CiteSpace, VOSviewer, and Bibliometrix (R-Tool of R-Studio).ResultsA total of 4866 publications from 2004 to 2022 were included in the bibliometric analysis. The number of publications shows an increasing trend from year to year. Collaborative network analysis shows that the United States and Germany are the most influential countries in this field, with the highest number of publications and citations. The journal with the most publications is Frontiers in Immunology. Brinkmann Volker is an authoritative author in this field, and his publication “Neutrophil extracellular traps kill bacteria” is the most frequently cited. The literature and keyword analysis shows that the relationship between NETs and diseases (hematological diseases, sepsis, cancer, etc.) and cell death (apoptosis, necroptosis, pyroptosis, etc.) is a popular research topic. Currently, NETs and SARS-CoV-2-related studies are at the forefront of the field.ConclusionThis study is the first to visualize the research in NETs-related fields using bibliometric methods, revealing the trends and frontiers of NETs research. This study will provide valuable references for scholars to find research focus questions and partners.

Research trends between diabetes mellitus and bariatric surgery researches: Bibliometric analysis and visualization from 1998 to 2023

“…The bibliometric analysis in this study utilized four tools: the 'bibliometrix' R package, 12 the bibliometric online analysis tool (www.bibliometric.com), CiteSpace 6.2.R4 12 , and VOSviewer 1.6.19. 12 Bibliometrix, developed by Italian professor Massimo Aria and colleagues, is a comprehensive bibliometric software package used for analysis and visualization in R. 13 This package enables data gathering and analysis of publication and citation counts for countries, institutions, journals, and authors. The 'Remap' package in R is employed to illustrate the distribution of research articles on world maps.…”

A bibliometric analysis of research foci and trends in cerebral ischemia-reperfusion injury involving autophagy during 2008 to 2022

“…Article co-citation analysis expresses the relationship between articles by analyzing the co-citation frequency of references. [28] When certain articles and journals are repeatedly quoted, the knowledge carriers cited are essentially recognized by the scientific community in which it is found, thus creating a scientific paradigm. [29] This paradigm relationship is visualized through Citespace to form a co-citation network that can reflect the knowledge base and research frontiers of an academic field.…”

Neutrophil microRNAs

“…The process of releasing NETs from the cell is called NETosis. Depending on the activator, NETosis can be lytic and results in the death of the neutrophil (classical pathway) or non-lytic, in which NETs are released as vesicles and the cell retains its primary functions (Brinkmann et al, 2004;Kenny et al, 2017;Wan et al, 2022). Linhares-Lacerda et al (2020) reported that NETs are also a carrier of miRNAs.…”