Bidimensional unconstrained optimization approach to EMD: An algorithm revealing skin perfusion alterations in pseudoxanthoma elasticum patients

Humeau-Heurtier, Anne; Colominas, Marcelo A.; Schlotthauer, Gastón; Etienne, Maxime; Martin, Ludovic; Ábrahám, Pierre

doi:10.1016/j.cmpb.2016.12.016

Cited by 9 publications

(6 citation statements)

References 57 publications

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“…Reports of the influence of microcirculatory alterations on macrocirculation are rare and inconsistent [7][8][9]. Yet, recent publication of HumeauHeurtier et al [10] described alterations in microvascular perfusion in PXE patients. This may connect to the decrease of ABI values after exercise, however, further research is needed on this matter.…”

Section: Discussionmentioning

confidence: 99%

A Case of Pseudoxanthoma Elasticum with Microvascular Alterations: Possible Explanations and Causes

Stumpf¹,

Steinmetz²,

Skowasch³

et al. 2017

Orthop Muscular Syst

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Section: Discussionmentioning

confidence: 99%

A Case of Pseudoxanthoma Elasticum with Microvascular Alterations: Possible Explanations and Causes

Stumpf¹,

Steinmetz²,

Skowasch³

et al. 2017

Orthop Muscular Syst

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“…Section 6.7.4 ) [ 126 ]. Although the potential of some novel methodology is being investigated, at this time [ 161 ], PET/CT scan is probably the best option available to evaluate treatment outcome in PXE patients, but it requires access to well-equipped medical centers. However, it is very likely that a combination of methodology and multiyear trials will be needed to achieve clear and objective results in the future.…”

Section: Rescue and Therapeutic Solutionsmentioning

confidence: 99%

ABCC6, Pyrophosphate and Ectopic Calcification: Therapeutic Solutions

Shimada

Pomozi

Zoll

et al. 2021

IJMS

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Pathological (ectopic) mineralization of soft tissues occurs during aging, in several common conditions such as diabetes, hypercholesterolemia, and renal failure and in certain genetic disorders. Pseudoxanthoma elasticum (PXE), a multi-organ disease affecting dermal, ocular, and cardiovascular tissues, is a model for ectopic mineralization disorders. ABCC6 dysfunction is the primary cause of PXE, but also some cases of generalized arterial calcification of infancy (GACI). ABCC6 deficiency in mice underlies an inducible dystrophic cardiac calcification phenotype (DCC). These calcification diseases are part of a spectrum of mineralization disorders that also includes Calcification of Joints and Arteries (CALJA). Since the identification of ABCC6 as the “PXE gene” and the development of several animal models (mice, rat, and zebrafish), there has been significant progress in our understanding of the molecular genetics, the clinical phenotypes, and pathogenesis of these diseases, which share similarities with more common conditions with abnormal calcification. ABCC6 facilitates the cellular efflux of ATP, which is rapidly converted into inorganic pyrophosphate (PPi) and adenosine by the ectonucleotidases NPP1 and CD73 (NT5E). PPi is a potent endogenous inhibitor of calcification, whereas adenosine indirectly contributes to calcification inhibition by suppressing the synthesis of tissue non-specific alkaline phosphatase (TNAP). At present, therapies only exist to alleviate symptoms for both PXE and GACI; however, extensive studies have resulted in several novel approaches to treating PXE and GACI. This review seeks to summarize the role of ABCC6 in ectopic calcification in PXE and other calcification disorders, and discuss therapeutic strategies targeting various proteins in the pathway (ABCC6, NPP1, and TNAP) and direct inhibition of calcification via supplementation by various compounds.

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“…e PEEMD algorithm, as an improvement of the EMD algorithm, is a generally nonlinear, nonstationary, and self-adaptive data processing method [7,12,21]. Under the assumption that the data may have some different coexisting modes of oscillations and some noise at the same time, PEEMD can extract the intrinsic modes in the original data without noise signals by utilizing permutation entropy (PE) [22,23] to estimate the effect of noise signals.…”

Section: Peemd Algorithmmentioning

confidence: 99%

An Approach for Reconstruction of Realistic Economic Data Based on Frequency Characteristics between IMFs

Gong

Han

et al. 2020

Mathematical Problems in Engineering

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Reconstruction of realistic economic data often causes social economists to analyze the underlying driving factors in time-series data or to study volatility. The intrinsic complexity of time-series data interests and attracts social economists. This paper proposes the bilateral permutation entropy (BPE) index method to solve the problem based on partly ensemble empirical mode decomposition (PEEMD), which was proposed as a novel data analysis method for nonlinear and nonstationary time series compared with the T-test method. First, PEEMD is extended to the case of gold price analysis in this paper for decomposition into several independent intrinsic mode functions (IMFs), from high to low frequency. Second, IMFs comprise three parts, including a high-frequency part, low-frequency part, and the whole trend based on a fine-to-coarse reconstruction by the BPE index method and the T-test method. Then, this paper conducts a correlation analysis on the basis of the reconstructed data and the related affected macroeconomic factors, including global gold production, world crude oil prices, and world inflation. Finally, the BPE index method is evidently a vitally significant technique for time-series data analysis in terms of reconstructed IMFs to obtain realistic data.

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Bidimensional unconstrained optimization approach to EMD: An algorithm revealing skin perfusion alterations in pseudoxanthoma elasticum patients

Abstract: For the first time, alterations in microvascular perfusion in PXE patients have been revealed. Our findings open new avenues for our understanding of pathophysiologic skin changes in PXE.

Cited by 9 publications

References 57 publications

A Case of Pseudoxanthoma Elasticum with Microvascular Alterations: Possible Explanations and Causes

A Case of Pseudoxanthoma Elasticum with Microvascular Alterations: Possible Explanations and Causes

ABCC6, Pyrophosphate and Ectopic Calcification: Therapeutic Solutions

An Approach for Reconstruction of Realistic Economic Data Based on Frequency Characteristics between IMFs

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