Bidirectional Association between Psoriasis and Atopic Dermatitis: A Nationwide Population-Based Cohort Study

Abstract

Background: There have been some reports on the coexistence of psoriasis and atopic dermatitis; however, the longitudinal relationship between these two diseases remains unclear. Objective: This study aimed to investigate the bidirectional association between psoriasis and atopic dermatitis. Methods: This cohort study recruited patients from the National Health Insurance Research Database in Taiwan. We included 8,206 patients with psoriasis and 32,824 matched controls to assess the risk of atopic dermatitis and 25,743 patients with atopic dermatitis and 102,972 matched controls to assess the risk of psoriasis. Cox regression model was used for the analyses. Results: After adjusting for potential confounders, patients with psoriasis had a higher risk of atopic dermatitis (adjusted hazard ratio [aHR] 13.01; 95% CI 10.23–16.56) than the controls. Patients with atopic dermatitis had a higher risk of psoriasis (aHR 10.37; 95% CI 6.85–15.69) than the controls. Stratified analyses revealed similar results in both sexes and all age groups. Conclusion: Our study demonstrated a bidirectional association between psoriasis and atopic dermatitis, suggesting that psoriasis and atopic dermatitis are not mutually exclusive and may share some biological mechanisms.

Migraine Headaches after Major Surgery with General or Neuraxial Anesthesia: A Nationwide Propensity-Score Matched Study

“…To protect personal privacy, a unique identification number is assigned to each beneficiary and enciphered before the data are released for research purposes. The NHI research database has been widely used in numerous epidemiological studies [ 22 , 23 , 24 , 25 ]. The present study used three Longitudinal Health Insurance Databases (LHID2000, LHID2005, and LHID2010), which randomly sampled 1 million beneficiaries from the original NHI research database in the years 2000, 2005, and 2010, respectively.…”

Psoriasis and Skin Comorbidities

“…Both diseases share many characteristics: high prevalence, chronicity, primary skin inflammation, associated comorbidities, important impact on the quality of patient's life due to itch and stigmatization. Some authors consider that the co-occurrence is an overlapping syndrome [35] and others found bidirectional association [36]. In Bozek's study [35] the patients with concomitant AD and psoriasis were frequently boys and overweight and had skin lesions equally distributed throughout the body.…”

Overlapping Features of Psoriasis and Atopic Dermatitis: From Genetics to Immunopathogenesis to Phenotypes

“…Moreover, IL-17 concentration was found to be significantly higher in PD than in AD or PSO. The role of the Th17 axis in PD was accordingly emphasized [ 9 ].…”

“…However, a recent study has shown a directional association between PSO and AD [ 9 ]. There are shared genetic profiles, immune pathways, pathologic changes, and comorbidities for the diseases.…”