Bidirectional influences between neurons and glial cells in the developing olfactory system

Tolbert, Leslie P.; Oland, Lynne A.; Tucker, Eric S.; Gibson, Nicholas J.; Higgins, Mark R.; Lipscomb, Brian W.

doi:10.1016/j.pneurobio.2004.04.004

Cited by 54 publications

(62 citation statements)

References 310 publications

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“…Analysis of Mas-AT-ir projections occuring at this period of AL development revealed that the protoglomeruli are devoid of Mas-AT immunostaining, suggesting that the LATn are not involved in the formation of the protoglomeruli. This fits the hypothesis that protoglomeruli are exclusively formed by ORNs and PNs, but not by LNs (Tolbert et al, 2004). With the beginning of the formation of the glomeruli (phase II) Mas-AT-ir processes enter the glomeruli, which is in accordance for a role of the LATn during formation of the synaptic network in the olfactory glomeruli.…”

Section: Possible Roles Of Mas-at and Other Neuropeptides During Al Dsupporting

confidence: 86%

“…Because of its early appearance in ORN axons, TM-MFas II can be used as a reliable marker for the formation of protoglomeruli, the templates for the later-forming glomeruli. In M. sexta, protoglomeruli are thought to be initially formed by axon endings of ORNs and uniglomerular PNs (uPNs; Malun et al, 1994; for a review, see Tolbert et al, 2004). Triple-immunolabeling with antisera against Mas-AT, TM-MFas II, and synapsin revealed between stage P6/7 to P7/8 no overlapping areas labeled with Mas-AT and TM-MFas II antisera (Fig.…”

Section: Mas-at-ir Projections In the Developing Al Neuropilmentioning

confidence: 99%

“…The antennal lobes (ALs) of the sphinx moth Manduca sexta serve as a well-established model for studying the neuronal development of the primary integration centers for odor information in the brain (Tolbert et al, 2004). ALs of insects compare to olfactory bulbs of vertebrates by sharing their principal morphological organization into so-called olfactory glomeruli, but also by a number of basic physiological properties with respect to information processing (Hildebrand and Shepherd, 1997;Strausfeld and Hildebrand, 1999;Eisthen, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Mas‐allatotropin in the developing antennal lobe of the sphinx moth Manduca sexta: Distribution, time course, developmental regulation, and colocalization with other neuropeptides

Utz

Huetteroth

Vömel

et al. 2007

Developmental Neurobiology

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ABSTRACT:The paired antennal lobes (ALs) of the sphinx moth Manduca sexta serve as a well-established model for studying development of the primary integration centers for odor information in the brain. To further reveal the role of neuropeptides during AL development, we have analyzed cellular distribution, developmental time course, and regulation of the neuropeptide M. sexta allatotropin (Mas-AT). On the basis of morphology and appearance during AL formation, seven major types of Mas-AT-immunoreactive (ir) cells could be distinguished. Mas-AT-ir cells are identified as local, projection, and centrifugal neurons, which are either persisting larval or newly added adult-specific neurons. Complementary immunostaining with antisera against two other neuropeptide families (A-type allatostatins, RFamides) revealed colocalization within three of the Mas-AT-ir cell types. On the basis of this neurochemistry, the most prominent type of Mas-AT-ir neurons, the local AT neurons (LATn), could be divided in three subpopulations. The appearance of the Mas-AT-ir cell types occurring during metamorphosis parallels the rising titer of the developmental hormone 20-hydroxyecdysone (20E). Artificially shifting the 20E titer to an earlier developmental time point resulted in the precocious occurrence of Mas-AT immunostaining. This result supports the hypothesis that the pupal rise of 20E is causative for Mas-AT expression during AL development. Comparing localization and developmental time course of Mas-AT and other neuropeptides with the time course of AL formation suggests various functions for these neuropeptides during development, including an involvement in the formation of the olfactory glomeruli. '

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Section: Possible Roles Of Mas-at and Other Neuropeptides During Al Dsupporting

confidence: 86%

Section: Mas-at-ir Projections In the Developing Al Neuropilmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mas‐allatotropin in the developing antennal lobe of the sphinx moth Manduca sexta: Distribution, time course, developmental regulation, and colocalization with other neuropeptides

Utz

Huetteroth

Vömel

et al. 2007

Developmental Neurobiology

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“…All neurons of the AL have been born by P3 . Beginning with P4, the olfactory receptor neurons (ORNs) enter the AL and induce, in association with antennal glial cells, the formation of glomeruli during the subsequent stages (for a review, see Tolbert et al 2004). After a short delay, mainly between P7/8 and P12, the interaction of ingrowing ORNs, glial cells, local (LNs) and projection (PNs) neurons leads to increased synaptogenesis in a distoproximally directed wave and to the stabilization of the glomeruli (Oland et al 1990;Tolbert and Sirianni 1990;Dubuque et al 2001).…”

Section: Introductionmentioning

confidence: 99%

“…After a short delay, mainly between P7/8 and P12, the interaction of ingrowing ORNs, glial cells, local (LNs) and projection (PNs) neurons leads to increased synaptogenesis in a distoproximally directed wave and to the stabilization of the glomeruli (Oland et al 1990;Tolbert and Sirianni 1990;Dubuque et al 2001). After P12, the glomeruli increase in size, probably because of the increasing neurite diameters, but the main wave of synaptogenesis seems to be complete (Tolbert et al 1983;Tolbert 1989; for reviews, see Oland and Tolbert 1996;Tolbert et al 2004). Nevertheless, the synaptic connections in the glomeruli are thought to undergo further maturation and refinement until eclosion (Tolbert et al 1983;Dubuque et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Standard three-dimensional glomeruli of the Manduca sexta antennal lobe: a tool to study both developmental and adult neuronal plasticity

Huetteroth

Schachtner

2005

Cell Tissue Res

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The metamorphosing antennal lobe (AL) of the sphinx moth Manduca sexta serves as an established model system for studying neuronal development. To improve our understanding of mechanisms involved in neuronal plasticity, we have analyzed the size, shape, and localization of ten identified glomeruli at three different time points during development and in the adult, viz., (1) 13 days after pupal eclosion (P13), which reflects a time when the basic glomerular map has formed, (2) immediately after adult eclosion (A0), which represents a time when the newly formed glomeruli are uninfluenced by external odors, and (3) 4 days after adult eclosion (A4), which reflects a time when the animals have been exposed to surrounding odors. Our data from normally developing ALs of male M. sexta from P13 to A0 revealed an increase in size of all examined glomeruli of between 40% and 130%, with the strongest increases occurring in two of the three sex-specific glomeruli (cumulus, toroid). From A0 to A4, the cumulus and toroid increased significantly when correlated to AL volume, whereas the other glomeruli reached the sizes gained after A0. This study was based on antibody staining against the ubiquitous synaptic vesicle protein synaptotagmin, confocal laser scan microscopy, and the three-dimensional (3D) analysis tool AMIRA. Tissue permeability and therefore reliability of the staining quality was enhanced by using formalin/methanol fixation. The standard 3D glomeruli introduced in this study can now be used as basic tools for further examination of neuronal plasticity at the level of the identified neuropil structures, viz., the glomeruli of the AL of M. sexta.

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Stenting of a stenosed major aortopulmonary collateral artery in a baby with pulmonary atresia and a ventricular septal defect: Rescue from critical hypoxia in the immediate postoperative stage of unifocalization supported by extracorporeal membrane oxygenation

Tomita

Matsuoka

Uemura

2008

Cathet Cardio Intervent

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A 4-month baby with pulmonary atresia, ventricular septal defect, major aortopulmonary collateral arteries (MAPCAs) and an extremely hypoplastic central pulmonary artery developed critical hypoxia following right unifocalization combined with a right Blalock-Taussig shunt. To increase pulmonary blood flow we stented the left lower MAPCA during extracorporeal membrane oxygenation (ECMO) support. He was successfully weaned from ECMO 2 days after stenting. Percutaneous intervention for a stenosed MAPCA is an effective means of increasing pulmonary blood flow in critically hypoxic patients following unilateral unifocalization, even in the immediate postoperative stage.

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Bidirectional influences between neurons and glial cells in the developing olfactory system

Cited by 54 publications

References 310 publications

Mas‐allatotropin in the developing antennal lobe of the sphinx moth Manduca sexta: Distribution, time course, developmental regulation, and colocalization with other neuropeptides

Mas‐allatotropin in the developing antennal lobe of the sphinx moth Manduca sexta: Distribution, time course, developmental regulation, and colocalization with other neuropeptides

Standard three-dimensional glomeruli of the Manduca sexta antennal lobe: a tool to study both developmental and adult neuronal plasticity

Stenting of a stenosed major aortopulmonary collateral artery in a baby with pulmonary atresia and a ventricular septal defect: Rescue from critical hypoxia in the immediate postoperative stage of unifocalization supported by extracorporeal membrane oxygenation

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