Bidirectional microfluidic pumping using an array of magnetic Janus microspheres rotating around magnetic disks

Beld, Wesley T. E. van den; Cadena, Natalia L.; Bomer, Johan G.; Weerd, Eddy L de; Abelmann, Léon; Berg, Albert van den; Eijkel, Jan C.T.

doi:10.1039/c5lc00199d

Cited by 16 publications

(7 citation statements)

References 18 publications

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“…This effect is minimal in a channel with a net axial flow, since in this case fluid does not stay at the edge of the array long enough to be moved across the channel by this localized effect. A similar effect of rotating beads on fluid pumping due to asymmetric channel geometry was recentlyreported[32]. Within the array itself, the advancement of fluorescence across the channel occurs in pockets.…”

supporting

confidence: 55%

Rapid microfluidic mixing via rotating magnetic microbeads

Owen

Ballard

Alexeev

et al. 2016

Sensors and Actuators A: Physical

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Presented here is a novel method for mixing in a microfluidic channel via an array of rotating magnetic microbeads. The microbeads rotate around circular permalloy (NiFe) features magnetized by a rotating external magnetic field. This system demonstrates rapid mixing in short channel lengths. The effectiveness of this system is quantified by analyzing the degree of mixing of two streams, one with fluorescence and one without. Our experiments and numerical simulations reveal that beads orbiting at a high velocity as compared to flow down the channel cause the fluid to form circular coronae that stretch across the microchannel leading to fluid mixing. Under these conditions, rotating magnetic microbeads were able to fully mix the streams in a 270 μm mixing region.

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supporting

confidence: 55%

Rapid microfluidic mixing via rotating magnetic microbeads

Owen

Ballard

Alexeev

et al. 2016

Sensors and Actuators A: Physical

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“…41 However, micropumping in closed systems is always a difficult issue without external pressure. 42 As one of the applications, our living micromotor is capable of active actuation, such as localized microfluidic pumping, and further of indirect manipulation of different targets, either immotile ones such as microparticles and biological cells or motile ones such as bacteria, as schematically shown in Figure 3a.…”

Section: ■ Localized Microfluidic Pumping and Indirect Manipulationmentioning

confidence: 99%

Optically Controlled Living Micromotors for the Manipulation and Disruption of Biological Targets

et al. 2020

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Bioinspired and biohybrid micromotors represent a revolution in microrobotic research and are playing an increasingly important role in biomedical applications. In particular, biological micromotors that are multifunctional and can perform complex tasks are in great demand. Here, we report living and multifunctional micromotors based on single cells (green microalgae: Chlamydomonas reinhardtii) that are controlled by optical force. The micromotor's locomotion can be carefully controlled in a variety of biological media including cell culture medium, saliva, human serum, plasma, blood, and bone marrow fluid. It exhibits the capabilities to perform multiple tasks, in particular, indirect manipulation of biological targets and disruption of biological aggregates including in vitro blood clots. These micromotors can also act as elements in reconfigurable motor arrays where they efficiently work collaboratively and synchronously. This work provides new possibilities for many in vitro biomedical applications including target manipulation, cargo delivery and release, and biological aggregate removal.

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“…However, exploiting this to achieve a net motion or flow is not intuitive because of the low Reynolds number hydrodynamics: a single rotator in an infinite fluid produces a rotlet flow field without any pumping 22 . One way to achieve a net flow is to place the colloid near a wall, which breaks the symmetry of the rotational flow 7–9 . Another possibility is self-assembled magnetic cilia that can produce fluid flow, if the pathways of the driving and recovery strokes are different 11,12,23 .…”

Section: Introductionmentioning

confidence: 99%

Controlling collective rotational patterns of magnetic rotors

et al. 2019

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Magnetic actuation is widely used in engineering specific forms of controlled motion in microfluidic applications. A challenge, however, is how to extract different desired responses from different components in the system using the same external magnetic drive. Using experiments, simulations, and theoretical arguments, we present emergent rotational patterns in an array of identical magnetic rotors under an uniform, oscillating magnetic field. By changing the relative strength of the external field strength versus the dipolar interactions between the rotors, different collective modes are selected by the rotors. When the dipole interaction is dominant the rotors swing upwards or downwards in alternating stripes, reflecting the spin-ice symmetry of the static configuration. For larger spacings, when the external field dominates over the dipolar interactions, the rotors undergo full rotations, with different quarters of the array turning in different directions. Our work sheds light on how collective behaviour can be engineered in magnetic systems.

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Bidirectional microfluidic pumping using an array of magnetic Janus microspheres rotating around magnetic disks

Cited by 16 publications

References 18 publications

Rapid microfluidic mixing via rotating magnetic microbeads

Rapid microfluidic mixing via rotating magnetic microbeads

Optically Controlled Living Micromotors for the Manipulation and Disruption of Biological Targets

Controlling collective rotational patterns of magnetic rotors

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