Bifidobacterium CECT 7765 modulates early stress-induced immune, neuroendocrine and behavioral alterations in mice

Moya-Pérez, Ángela; Pérez-Villalba, Ana; Benı́tez-Páez, Alfonso; Campillo, Isabel; Sanz, Yolanda

doi:10.1016/j.bbi.2017.05.011

Cited by 147 publications

(83 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is well known that the cytokine TNF-␣ is directly involved in IR via the impairment of insulin-mediated cell signaling in metabolic organs, such as adipose tissue (24). Furthermore, the inflammatory milieu of the obese intestine may also reflect imbalances in immune cell populations with a proinflammatory profile, as shown in animal studies (25), which participate in the immune cell traffic from the gut to other lymphoid organs such as the white adipose tissue, triggering inflammation (21).…”

Section: Discussionmentioning

confidence: 99%

Depletion of Blautia Species in the Microbiota of Obese Children Relates to Intestinal Inflammation and Metabolic Phenotype Worsening

et al. 2020

View full text Add to dashboard Cite

Cross-sectional studies conducted with obese and control subjects have suggested associations between gut microbiota alterations and obesity, but the links with specific disease phenotypes and proofs of causality are still scarce. The present study aimed to profile the gut microbiota of lean and obese children with and without insulin resistance to characterize associations with specific obesity-related complications and understand the role played in metabolic inflammation. Through massive sequencing of 16S rRNA gene amplicons and data analysis using a novel permutation approach, we have detected decreased incidence of Blautia species, especially Blautia luti and B. wexlerae, in the gut microbiota of obese children, which was even more pronounced in cases with both obesity and insulin resistance. There was also a parallel increase in proinflammatory cytokines and chemokines (gamma interferon [IFN-γ], tumor necrosis factor alpha [TNF-α], and monocyte chemoattractant protein 1 [MCP-1]) in feces of obese children compared to those of lean ones. B. luti and B. wexlerae were also shown to exert an anti-inflammatory effect in peripheral blood mononuclear cell cultures in vitro, compared to non-obesity-associated species. We suggest that the depletion of B. luti and B. wexlerae species in the gut ecosystem may occur in cases of obesity and contribute to metabolic inflammation leading to insulin resistance. IMPORTANCE Child obesity constitutes a risk factor for developing insulin resistance which, if sustained, could lead to more severe conditions like type 2 diabetes (T2D) in adulthood. Our study identified previously unknown species whose depletion (Blautia luti and Blautia wexlerae) is associated with insulin resistance in obese individuals. Our results also indicate that these bacterial species might help to reduce inflammation causally linked to obesity-related complications. Childhood is considered a window of opportunity to tackle obesity. These new findings provide, therefore, valuable information for the future design of microbiota-based strategies for the early prevention of obesity-related complications.

show abstract

Section: Discussionmentioning

confidence: 99%

Depletion of Blautia Species in the Microbiota of Obese Children Relates to Intestinal Inflammation and Metabolic Phenotype Worsening

et al. 2020

View full text Add to dashboard Cite

show abstract

“…It is, thus, unclear if B. pseudocatenulatum would decrease depression in mice without obesity. Another study showed that anxiety-like behaviors diminished in chronic-stressed mice fed with B. pseudocatenulatum, but depressive-like behaviors were unevaluated (Moya-Perez et al, 2017). Therefore, further studies are required to determine whether B. pseudocatenulatum has an independent antidepressive effect.…”

Section: Candidate Probiotics With Potential Antidepressive Effectmentioning

confidence: 99%

Antidepressive Mechanisms of Probiotics and Their Therapeutic Potential

et al. 2020

View full text Add to dashboard Cite

The accumulating knowledge of the host-microbiota interplay gives rise to the microbiota-gut-brain (MGB) axis. The MGB axis depicts the interkingdom communication between the gut microbiota and the brain. This communication process involves the endocrine, immune and neurotransmitters systems. Dysfunction of these systems, along with the presence of gut dysbiosis, have been detected among clinically depressed patients. This implicates the involvement of a maladaptive MGB axis in the pathophysiology of depression. Depression refers to symptoms that characterize major depressive disorder (MDD), a mood disorder with a disease burden that rivals that of heart diseases. The use of probiotics to treat depression has gained attention in recent years, as evidenced by increasing numbers of animal and human studies that have supported the antidepressive efficacy of probiotics. Physiological changes observed in these studies allow for the elucidation of probiotics antidepressive mechanisms, which ultimately aim to restore proper functioning of the MGB axis. However, the understanding of mechanisms does not yet complete the endeavor in applying probiotics to treat MDD. Other challenges remain which include the heterogeneous nature of both the gut microbiota composition and depressive symptoms in the clinical setting. Nevertheless, probiotics offer some advantages over standard pharmaceutical antidepressants, in terms of residual symptoms, side effects and stigma involved. This review outlines antidepressive mechanisms of probiotics based on the currently available literature and discusses therapeutic potentials of probiotics for depression.

show abstract

“…In wild red squirrels ( Tamiasciurus hudsonicus ), high levels of fecal glucocorticoid metabolites were associated with lower bacterial diversity in the oral microbiome (Stothart et al, 2016 ). Administration of Bifidobacterium pseudocatenulatum CECT 7765 to C57Bl/6J previously subjected to maternal separation-induced stress modulates intestinal neurotransmitter and cytokine network to result in an improved HPA axis response (Moya-Perez et al, 2017 ).…”

Section: Gut Microbiome Changes and Secondary Host Effectsmentioning

confidence: 99%

Gut Dysbiosis in Animals Due to Environmental Chemical Exposures

Rosenfeld

2017

Front. Cell. Infect. Microbiol.

183

104

View full text Add to dashboard Cite

The gut microbiome consists of over 103–104 microorganism inhabitants that together possess 150 times more genes that the human genome and thus should be considered an “organ” in of itself. Such communities of bacteria are in dynamic flux and susceptible to changes in host environment and body condition. In turn, gut microbiome disturbances can affect health status of the host. Gut dysbiosis might result in obesity, diabetes, gastrointestinal, immunological, and neurobehavioral disorders. Such host diseases can originate due to shifts in microbiota favoring more pathogenic species that produce various virulence factors, such as lipopolysaccharide. Bacterial virulence factors and metabolites may be transmitted to distal target sites, including the brain. Other potential mechanisms by which gut dysbiosis can affect the host include bacterial-produced metabolites, production of hormones and factors that mimic those produced by the host, and epimutations. All animals, including humans, are exposed daily to various environmental chemicals that can influence the gut microbiome. Exposure to such chemicals might lead to downstream systemic effects that occur secondary to gut microbiome disturbances. Increasing reports have shown that environmental chemical exposures can target both host and the resident gut microbiome. In this review, we will first consider the current knowledge of how endocrine disrupting chemicals (EDCs), heavy metals, air pollution, and nanoparticles can influence the gut microbiome. The second part of the review will consider how potential environmental chemical-induced gut microbiome changes might subsequently induce pathophysiological responses in the host, although definitive evidence for such effects is still lacking. By understanding how these chemicals result in gut dysbiosis, it may open up new remediation strategies in animals, including humans, exposed to such chemicals.

show abstract

Bifidobacterium CECT 7765 modulates early stress-induced immune, neuroendocrine and behavioral alterations in mice

Cited by 147 publications

References 61 publications

Depletion of Blautia Species in the Microbiota of Obese Children Relates to Intestinal Inflammation and Metabolic Phenotype Worsening

Depletion of Blautia Species in the Microbiota of Obese Children Relates to Intestinal Inflammation and Metabolic Phenotype Worsening

Antidepressive Mechanisms of Probiotics and Their Therapeutic Potential

Gut Dysbiosis in Animals Due to Environmental Chemical Exposures

Contact Info

Product

Resources

About