Bifunctional fluorescent probe for the recognition of hydrazine and bisulfite in lipid droplets

Han, Yuling; Huang, Yuzhen; Qi, Lin; Tang, Luyao; Yang, Guiyi; Xin, Haotian; Zhao, Songfang; Guan, Ruifang; Wang, Kang‐Nan; Cao, Duxia

doi:10.1016/j.snb.2023.134181

Cited by 15 publications

(2 citation statements)

References 48 publications

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“…The reversible binding is susceptible to interference from other endogenous molecules and exogenous substances with high affinity, resulting in a large deviation in actual quantification . Numerous studies have reported that fluorescent probes can be used for visual analysis and real-time imaging monitoring of microscopic-level analytes in complex biological environments by imparting light color and intensity changes, which is of great significance to our in-depth understanding of the microscopic world. − Quantitative detection and visualization of HSA through fluorescent probes provide an important impetus for developing life sciences.…”

Section: Introductionmentioning

confidence: 99%

Development of Human Serum Albumin Fluorescent Probes in Detection, Imaging, and Disease Therapy

Wang,

Huo,

Yin

2024

J. Phys. Chem. B

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Human serum albumin (HSA) acts as a repository and transporter of substances in the blood. An abnormal concentration may indicate the occurrence of liver-and kidney-related diseases, which has attracted people to investigate the precise quantification of HSA in body fluids. Fluorescent probes can combine with HSA covalently or noncovalently to quantify HSA in urine and plasma. Moreover, probes combined with HSA can improve its photophysical properties; probe-HSA has been applied in real-time monitoring and photothermal and photodynamic therapy in vivo. This Review will introduce fluorescent probes for quantitative HSA according to the three reaction mechanisms of spatial structure, enzymatic reaction, and self-assembly and systematically introduce the application of probes combined with HSA in disease imaging and phototherapy. It will help develop multifunctional applications for HSA probes and provide assistance in the early diagnosis and treatment of diseases.

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Section: Introductionmentioning

confidence: 99%

Development of Human Serum Albumin Fluorescent Probes in Detection, Imaging, and Disease Therapy

Wang,

Huo,

Yin

2024

J. Phys. Chem. B

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“…At present, most fluorescent probes for the detection of hydrazine are based on the following reaction mechanisms: nucleophilic substitution of hydrazine for methylenemalononitrile, 11–14 condensation of hydrazine and aldehydes or ketones, 15 deprotection of acetyl groups and their derivatives, 16–18 and hydrazine-induced cyclization or ring-opening reactions. 19–22 Unfortunately, the fluorescence of these hydrazine identification probes is easily quenched in aqueous solutions or in the solid state due to the aggregation-caused quenching (ACQ) effect, which greatly limits their application.…”

Section: Introductionmentioning

confidence: 99%

An AIE-active tetra-aryl imidazole-derived chemodosimeter for turn-on recognition of hydrazine and its bioimaging in living cells

Li,

Yuan,

Cheng

et al. 2024

Org. Biomol. Chem.

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5‐N,N‐Diarylaminothiazoles with Electron‐Accepting Groups: Synthesis, Photophysical Properties, and Their Application for the Detection of Hydrazine Hydrate

Murai,

Tanaka,

Takekoshi

et al. 2023

Eur J Org Chem

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Abstract5‐N,N‐diarylaminothiazoles containing cyano and nitro groups were synthesized using the Pd‐catalyzed Buchwald‐Hartwig amination reaction with good yields. The cyano group in the resultant thiazole was reduced to a formyl group. This was then subjected to the Knoevenagel condensation reaction, leading to the formation of thiazoles with a dicyanovinyl group. The nitro group in the thiazole was reduced to an amino group, which was subsequently reacted with triphosgene, yielding a thiazole with an isocyanate group. These thiazoles, with their electron‐accepting properties, demonstrated absorption and emission spectra at longer wavelengths. Notably, the thiazole containing the dicyanovinyl group displayed a red emission. Tests for the detection of hydrazine, a hazardous volatile organic compound, were conducted using the synthesized thiazoles. The results showed that the dicyanovinyl group effectively responded to hydrazine hydrate, evidenced by changes in the absorption and emission spectra. This change in color was also visibly detectable to the naked eye.

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Bifunctional fluorescent probe for the recognition of hydrazine and bisulfite in lipid droplets

Cited by 15 publications

References 48 publications

Development of Human Serum Albumin Fluorescent Probes in Detection, Imaging, and Disease Therapy

Development of Human Serum Albumin Fluorescent Probes in Detection, Imaging, and Disease Therapy

An AIE-active tetra-aryl imidazole-derived chemodosimeter for turn-on recognition of hydrazine and its bioimaging in living cells

5‐N,N‐Diarylaminothiazoles with Electron‐Accepting Groups: Synthesis, Photophysical Properties, and Their Application for the Detection of Hydrazine Hydrate

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