Bilateral Acute Retinal Necrosis with Concurrent Retinopathy of Prematurity in Two Neonates

LaMattina, Kara C.; Wirostko, William J.; Costakos, Deborah M.

doi:10.3109/09273948.2014.916724

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…Bilateral necrotising retinitis is a rare presenting feature of CMV. There has been report of coexistent ARN with ROP in a premature infant but CMV has not been implicated as an etiology so far 8 …”

Section: Discussionmentioning

confidence: 99%

Bilateral acute necrotizing retinitis due to cytomegalovirus infection in an infant: Challenging case report

Mahendradas

Sinha

Vinekar

et al. 2019

American Journal of Ophthalmology Case Reports

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PurposeTo report a case of bilateral acute necrotising retinitis due to cytomegalovirus infection (CMV) in an Asian Indian infant.ObservationsAn Asian Indian infant born with a birth weight of 1000 g at 26 week of gestation acquired cytomegalovirus infection from repeated blood transfusion for anemia. During the routine course of ROP screening, both eyes were detected with Type 1 ROP (stage 3 in zone 1 with plus disease) and treated with laser photoablation at 39 + 2 weeks post menstrual age. The disease responded to the laser and showed signs of regression. Four weeks after laser therapy (PMA 43 + 3 weeks), both eyes presented with vitritis, inferior vitreous condensation and white lesions in the lower nasal retina and temporal retina overlying the lasered retinal bed associated with white fluffy hemorrhagic lesions resembling necrotising retinitis. As the infant was seropositive for CMV earlier, Necrotising retinitis due to CMV was suspected. The CMV DNA was repeated and was detected in serum. Infant was treated with anti-CMV medication (oral valgancyclovir) for six weeks. The retinal lesions resolved completely.Conclusion and ImportanceBilateral acute necrotising retinitis may present in an infant on post lasered retina as early as 16 weeks after birth. CMV may also present as acute necrotising retinitis in unusual cases therefore high index of suspicion and early management can result in a successful outcome.

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Section: Discussionmentioning

confidence: 99%

Bilateral acute necrotizing retinitis due to cytomegalovirus infection in an infant: Challenging case report

Mahendradas

Sinha

Vinekar

et al. 2019

American Journal of Ophthalmology Case Reports

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“…Several other viruses also have a predilection for both premature infants and children with IEI and can present with ocular disease (28). Enteroviral retinopathy and CMV retinitis have been observed in full-term infants with SCID (29,30). Preterm infants are routinely surveyed for retinopathy of prematurity (ROP) while in the NICU.…”

Section: Viral Diseasementioning

confidence: 99%

Inborn Errors of Immunity in the Premature Infant: Challenges in Recognition and Diagnosis

Gordon

O’Connell

2021

Front. Immunol.

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Due to heightened awareness and advanced genetic tools, inborn errors of immunity (IEI) are increasingly recognized in children. However, diagnosing of IEI in premature infants is challenging and, subsequently, reports of IEI in premature infants remain rare. This review focuses on how common disorders of prematurity, such as sepsis, necrotizing enterocolitis, and bronchopulmonary dysplasia, can clinically overlap with presenting signs of IEI. We present four recent cases from a single neonatal intensive care unit that highlight diagnostic dilemmas facing neonatologists and clinical immunologists when considering IEI in preterm infants. Finally, we present a conceptual framework for when to consider IEI in premature infants and a guide to initial workup of premature infants suspected of having IEI.

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Neonatal bilateral acute retinal necrosis in a neonate with a history of severe intrauterine growth restriction

Gómez

Naranjo

Carrasquilla

et al. 2019

Journal of American Association for Pediatric Ophthalmology and

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Bilateral Acute Retinal Necrosis with Concurrent Retinopathy of Prematurity in Two Neonates

Cited by 6 publications

References 11 publications

Bilateral acute necrotizing retinitis due to cytomegalovirus infection in an infant: Challenging case report

Bilateral acute necrotizing retinitis due to cytomegalovirus infection in an infant: Challenging case report

Inborn Errors of Immunity in the Premature Infant: Challenges in Recognition and Diagnosis

Neonatal bilateral acute retinal necrosis in a neonate with a history of severe intrauterine growth restriction

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