Bilateral anterior ischaemic optic neuropathy following amiodarone

Palimar, Prasad; Cota, Nolan

doi:10.1038/eye.1998.227

Cited by 12 publications

(6 citation statements)

References 9 publications

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“…[63][64][65][66] The problem in determining an association between amiodarone and NAION is that patients who are placed on amiodarone generally have severe cardiovascular disease as well as other vascular risk factors (eg, hyperlipidaemia and hypertension). Thus, they are already predisposed to developing spontaneous NAION.…”

Section: Risk Factorsmentioning

confidence: 99%

Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy

Miller

Arnold

2014

Eye

191

139

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Nonarteritic anterior ischaemic optic neuropathy (NAION) is the most common acute optic neuropathy in patients over the age of 50 and is the second most common cause of permanent optic nerve-related visual loss in adults after glaucoma. Patients typically present with acute, painless, unilateral loss of vision associated with a variable visual field defect, a relative afferent pupillary defect, a swollen, hyperaemic optic disc, and one or more flame-shaped peripapillary retinal haemorrhages. The pathogenesis of this condition is unknown, but it occurs primarily in patients with structurally small optic discs that have little or no cup and a variety of underlying vascular disorders that may or may not be known at the time of visual loss. There is no consistently beneficial medical or surgical treatment for the condition, but there are now animal models that allow testing of various potential therapies. About 40% of patients experience spontaneous improvement in visual acuity. Patients in whom NAION occurs in one eye have a 15-19% risk of developing a similar event in the opposite eye over the subsequent 5 years.

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Section: Risk Factorsmentioning

confidence: 99%

Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy

Miller

Arnold

2014

Eye

191

139

View full text Add to dashboard Cite

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“…Amiodarone, an important antiarrhythmic drug, has been known for its ocular side‐effects (Gittinger & Asdourian ; Palimar & Cota ; Johnson et al. ).…”

Section: Other Drugsmentioning

confidence: 99%

Toxic optic neuropathies: an updated review

Grzybowski

Zülsdorff²,

Wilhelm

et al. 2014

Acta Ophthalmologica

159

132

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ABSTRACT.Toxic optic neuropathy (TON) is caused by the damage to the optic nerve through different toxins, including drugs, metals, organic solvents, methanol and carbon dioxide. A similar clinical picture may also be caused by nutritional deficits, including B vitamins, folic acid and proteins with sulphur-containing amino acids. This review summarizes the present knowledge on disease-causing factors, clinical presentation, diagnostics and treatment in TON. It discusses in detail known and hypothesized relations between drugs, including tuberculostatic drugs, antimicrobial agents, antiepileptic drugs, antiarrhythmic drugs, disulfiram, halogenated hydroquinolones, antimetabolites, tamoxifen and phosphodiesterase type 5 inhibitors and optic neuropathy.Key words: adalimumab optic neuropathy -antitumor necrosis factor alpha optic neuropathycuban epidemic optic neuropathy -ethambutol optic neuropathy -infliximab optic neuropathy -Leber's hereditary optic neuropathy -nutritional optic neuropathy -tobaccoalcohol amblyopia -toxic optic neuropathy Acta Ophthalmol. 2015: 93: 402-410

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“…The proposed risk factors include: (1) the anatomic predisposition of a “crowded” optic disk [4], [5]; (2) systematic conditions, such as hypertension [6], [7], diabetes mellitus (DM) [8]–[10], hyperlipidemia [6], [10], [11], sleep apnea syndrome[12], [13] and nocturnal hypotension [14], [15]; (3) side effects of some medical or surgical interventions, such as erectile dysfunction drugs [16], [17], amiodarone [18], [19], instance liposuction and hemodialysis [20]; and (4) genetic factors [20]–[23]. Among these factors, DM, an important risk factor, needs further investigation.…”

Section: Introductionmentioning

confidence: 99%

The Association between Diabetes Mellitus and Nonarteritic Anterior Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis

et al. 2013

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BackgroundThe association of diabetes mellitus (DM) with nonarteritic anterior ischemic optic neuropathy (NAION) has been inconclusive.PurposeTo determine whether DM is associated with an increased risk of NAION.MethodsA comprehensive literature search was performed for published studies reporting both DM and NAION based on PubMed and EMBASE. After reviewing characteristics of all the included studies systematically, meta-analytical method was employed to calculate the pooled odds ratio (OR) and associated 95% confidence interval (CI) from random-effects models. Heterogeneity was assessed by Q-statistic test. Funnel Plot, Begg's and Egger's linear regression test were applied to evaluate publication bias. A sensitivity analysis and meta-regression analysis were also performed to assess the robustness of results.Results2,096 participants from 12 case-control studies were pooled for a meta-analysis. The result of meta-analysis of these studies indicated that DM is associated with increased risk of NAION (pooled OR = 1.64, 95% CI = 1.17–2.30; P = 0.004). Sensitivity analysis indicated our findings are robust, and meta-regression analysis revealed no significant effect in terms of geographical area, gender, age of patients with NAION, the year of the publication, source of the controls, and sample size (all p>0.05). Evidence of publication bias was not observed in our study.ConclusionMeta-analysis suggests that DM might be associated with increased risk of NAION.

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Bilateral anterior ischaemic optic neuropathy following amiodarone

Cited by 12 publications

References 9 publications

Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy

Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy

Toxic optic neuropathies: an updated review

The Association between Diabetes Mellitus and Nonarteritic Anterior Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis

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