Bilateral Calcifying Odontogenic Cyst: A Rare Entity

Gadipelly, Srinivas; Reddy, Vijay Bhaskar; Sudheer, M. V. S.; Kumar, Nitin; Harsha, G.

doi:10.1007/s12663-014-0706-9

Cited by 15 publications

(25 citation statements)

References 20 publications

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“…In the present review of the literature on COC, DGCT, and GCOC, many publications did not describe full radiographic findings. It is true that radiological features, although suggestive, do not define the diagnosis of COC and DGCT . However, for future case reports, a better description of the radiographic findings is encouraged.…”

Section: Discussionmentioning

confidence: 99%

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Calcifying odontogenic cyst, dentinogenic ghost cell tumor, and ghost cell odontogenic carcinoma: A systematic review

Arruda

Monteiro

Abreu

et al. 2018

J Oral Pathology Medicine

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Section: Discussionmentioning

confidence: 99%

“…It is true that radiological features, although suggestive, do not define the diagnosis of COC and DGCT. [31][32][33][34] However, for future case reports, a better description of the radiographic findings is encouraged.…”

Section: Discussionmentioning

confidence: 99%

Calcifying odontogenic cyst, dentinogenic ghost cell tumor, and ghost cell odontogenic carcinoma: A systematic review

Arruda

Monteiro

Abreu

et al. 2018

J Oral Pathology Medicine

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“…It is likely that the noticed various distribution Immunohistochemical Expression of Cortactin, E-Cadherin, and MDM2 Proteins in Solid Ameloblastoma (313) form for cortactin in ameloblastoma epithelial and stromal cells could reflect the various steps of actin turnover. It was found that although SAB and OKC exhibit slow growth; however, they have local invasive manners and high rate of recurrence if not treated with more aggressive actions (27,(34)(35)(36) .…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Expression of Cortactin, E-Cadherin, and MDM2 Proteins in Solid Ameloblastoma versus Odontogenic Keratocyst (An immunohistochemical study)

et al. 2019

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Purpose:The extent of invasion can be analyzed by the expression and production of various genes and proteins by lesional cells. However, current clinical parameters lack the potential to predict the neoplastic behavior in solid ameloblastoma (SAB) and odontogenic keratocyst (OKC). Cortactin, an F-actin binding protein, overexpression has been correlated with advanced clinic pathological stage and poor prognosis in several tumors. E-cadherin belongs to the classical cadherins which. Low E-cadherin expression correlated to aggressive, poorly differentiated, high-grade carcinomas and low patient survival. Human-murine double minute 2 (MDM2), contributes to the promotion of cell growth, survival, invasion, and therapeutic resistance, overexpression of MDM2 has been observed in various human cancers and can contribute to genomic instability, thus, further promoting tumorigenesis. The purpose of this work was to investigate the role of Cortactin, E-Cadherin, MDM2 proteins expression in SAB and OKC and correlate the expression of these markers with the aggressive behavior of these tumors. Material and method: 10 case of solid ameloblastoma with its different histologic variants and 10 cases of the keratocystic odontogenic tumor were collected as paraffin embedded blocks. An immunohistochemical investigation using, Cortactin, E-Cadherin, and MDM2 antibodieswere done for all specimens. Results: The mean area percent of immunoexpression of Cortactin was greatest in SAB while, the mean area percent of immunoexpression of E-Cadherin, MDM2 were greatest in OKC. Conculsion:According to the current study, the absence of any significant differences between AB and OKC indicate the neoplastic and aggressive nature of OKC similar to AB.

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“…There are cases of COC discovered during the avulsion of mandibular wisdom teeth after histological analysis of the pseudofollicular sac [2]. COC can be found in patients of all ages, equally in young children, adolescents, and adults [2,3].…”

Section: Discussionmentioning

confidence: 99%

Calcifying odontogenic cyst: a report of two clinical cases

Lagarde

Sturque

Fénelon

et al. 2019

J Oral Med Oral Surg

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Introduction: Cystic maxillary lesions are common. In 1962, Gorlin described a rare cystic form termed the calcifying odontogenic cyst (COC) or Gorlin's cyst. Two cases of this form were treated at Bordeaux University Hospital. Observation: The first case was a 17-year-old patient with mandibular odontoma, which had developed over the previous 6 months. Excision was performed under local anesthesia, and the diagnosis of COC was made following pathological analysis. A 6-month follow-up was planned. The second case was a 62-year-old patient with a post-extraction mandibular lesion, which had been evolving for 1 year. Enucleation under local anesthesia led to the diagnosis of COC. No recurrence was observed after 5 years of follow-up. Discussion: COCs are rare lesions affecting mainly the anterior aspect of the mandible. COCs are usually discovered in unforeseen circumstances, and they can be observed as a clinically painless and well-defined oral deformation. Radiological examination often reveals radiolucent and uniloculated lesions, sometimes associated with radiopaque lesions. Pathological analyses are required for final diagnosis. Management is based on complete excision, more or less associated with marsupialization, and requires an annual clinical radiographic monitoring over the next 5 years. Conclusion: COC are rare lesions, usually asymptomatic, whose treatment is based on complete excision. Clinical and radiological follow-up is necessary until complete reossification is achieved.

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Bilateral Calcifying Odontogenic Cyst: A Rare Entity

Cited by 15 publications

References 20 publications

Calcifying odontogenic cyst, dentinogenic ghost cell tumor, and ghost cell odontogenic carcinoma: A systematic review

Calcifying odontogenic cyst, dentinogenic ghost cell tumor, and ghost cell odontogenic carcinoma: A systematic review

Immunohistochemical Expression of Cortactin, E-Cadherin, and MDM2 Proteins in Solid Ameloblastoma versus Odontogenic Keratocyst (An immunohistochemical study)

Calcifying odontogenic cyst: a report of two clinical cases

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