Bilateral Cortical Interaction: Modulation of Delay-Tuned Neurons in the Contralateral Auditory Cortex

Tang, Jie; Xiao, Zhongju; Suga, Nobuo

doi:10.1523/jneurosci.1257-07.2007

Cited by 24 publications

(33 citation statements)

References 42 publications

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“…Another likely possibility is the combination of tone responses with ‘on’, ‘off’ and ‘sustained’ temporal response profiles (Qin et al, 2003; Wang et al, 2005) that could generate delays of the order of tens of milliseconds. In echolocating bats, inter-hemispherical connections may generate delays of the order of a few milliseconds (Tang et al, 2007). Further experiments are necessary to test these hypotheses in primates.…”

Section: Discussionmentioning

confidence: 99%

Nonlinear Spectrotemporal Interactions Underlying Selectivity for Complex Sounds in Auditory Cortex

Sadagopan

Wang²

2009

J. Neurosci.

132

139

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In the auditory cortex of awake animals, a substantial number of neurons do not respond to pure tones. These neurons have historically been classified as "unresponsive" and even been speculated as being nonauditory. We discovered, however, that many of these neurons in the primary auditory cortex (A1) of awake marmoset monkeys were in fact highly selective for complex sound features. We then investigated how such selectivity might arise from the tone-tuned inputs that these neurons likely receive. We found that these non-tone responsive neurons exhibited nonlinear combination-sensitive responses that require precise spectral and temporal combinations of two tone pips. The nonlinear spectrotemporal maps derived from these neurons were correlated with their selectivity for complex acoustic features. These non-tone responsive and nonlinear neurons were commonly encountered at superficial cortical depths in A1. Our findings demonstrate howtemporallyandspectrallyspecificnonlinearintegrationofputativetone-tunedinputsmightunderlieadiverserangeofhighselectivityofA1 neurons in awake animals. We propose that describing A1 neurons with complex response properties in terms of tone-tuned input channels can conceptually unify a wide variety of observed neural selectivity to complex sounds into a lower dimensional description.

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Section: Discussionmentioning

confidence: 99%

Nonlinear Spectrotemporal Interactions Underlying Selectivity for Complex Sounds in Auditory Cortex

Sadagopan

Wang²

2009

J. Neurosci.

132

139

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“…Surgery, acoustic and electric stimulation, and recording of neural activity were the same as those described (11,25). The protocol for the present research was approved by the Animal Studies Committee of Washington University.…”

Section: Methodsmentioning

confidence: 99%

Modulation of auditory processing by cortico-cortical feed-forward and feedback projections

Tang

Suga

2008

Proc. Natl. Acad. Sci. U.S.A.

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The auditory center in the cerebrum, the auditory cortex, consists of multiple interconnected areas. The functional role of these interconnections is poorly understood. The auditory cortex of the mustached bat consists of at least nine areas, including the frequency modulation-frequency modulation (FF) and dorsal fringe (DF) areas. The FF and DF areas consist of neurons tuned to specific echo delays carrying target-distance information. The DF area is hierarchically at a higher level than the FF area. Here, we show that the feedback projection from the DF area to the FF area shifts the delay-tuning of FF neurons toward that of the stimulated DF neurons. In contrast, the feed-forward projection from the FF area to the DF area shifts the delay-tuning of DF neurons away from that of the stimulated FF neurons. The lateral projection within the DF area shifts the delay-tuning of DF neurons toward that of the stimulated DF neurons. In contrast, the lateral projection within the FF area shifts the delay-tuning of FF neurons away from that of the stimulated FF neurons. The delay-tuning shift evoked by the DF stimulation was 2.5 times larger than that evoked by the FF stimulation. Our data indicate that the FF-DF feed-forward and FF-FF lateral projections shape the highly selective neural representation of the tuning of the excited DF neurons, whereas the DF-FF feedback and DF-DF lateral projections enhance the representation of the selected tuning, perhaps, for focal processing of information carried by the excited FF neurons.bat ͉ cortical electric stimulation ͉ delay tuning ͉ hearing ͉ plasticity T he auditory center in the cerebrum, the auditory cortex, consists of multiple, anatomically distinct areas, as do other sensory cortices. Its functional organization beyond tonotopy, however, has hardly been explored, except for the auditory cortex of the mustached bat, Pteronotus parnellii. Tonotopically organized cortical auditory areas are commonly interconnected (1). The cortico-cortical interaction within the primary auditory cortex has been studied (2-6). However, the cortico-cortical interaction between different cortical auditory areas has not yet been studied. The interaction between different cortical areas in a sensory system has thus far been studied only in the cat visual cortex by Galuske et al. (7). They found that inactivation of the visuoparietal cortex decreases the orientation and direction sensitivities of neurons in area 18. That is, they studied the effect of the feedback projection (the projection from a higher to a lower area in a signal processing hierarchy), but not that of the feed-forward projection (the projection from a lower to a higher area).A microchiropteran bat emits orientation sounds (biosonar pulses or, simply, pulses) and listens to their echoes for echolocation. The delay of an echo from the emitted pulse carries target-distance information. In the mustached bat, the biosonar pulse consists of a long constant frequency (CF) and a short frequency-modulated (FM) component, and these com...

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“…5e). In other words, lateral, contralateral, feedforward and/or feedback modulations by the FF area are centrifugal but those of the DF area are centripetal (Xiao and Suga 2004; Tang et al 2007; Tang and Suga 2008, 2009). In addition, it has also been known that feedback modulation of the VF area to the FF area is centripetal (Fig.…”

Section: (2) Corticocortical Modulation By the Lateral Contralateralmentioning

confidence: 99%

Tuning shifts of the auditory system by corticocortical and corticofugal projections and conditioning

Suga

2012

Neuroscience & Biobehavioral Reviews

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The central auditory system consists of the lemniscal and nonlemniscal systems. The thalamic lemniscal and non-lemniscal auditory nuclei are different from each other in response properties and neural connectivities. The cortical auditory areas receiving the projections from these thalamic nuclei interact with each other through corticocortical projections and project down to the subcortical auditory nuclei. This corticofugal (descending) system forms multiple feedback loops with the ascending system. The corticocortical and corticofugal projections modulate auditory signal processing and play an essential role in the plasticity of the auditory system. Focal electric stimulation -- comparable to repetitive tonal stimulation -- of the lemniscal system evokes three major types of changes in the physiological properties, such as the tuning to specific values of acoustic parameters of cortical and subcortical auditory neurons through different combinations of facilitation and inhibition. For such changes, a neuromodulator, acetylcholine, plays an essential role. Electric stimulation of the nonlemniscal system evokes changes in the lemniscal system that is different from those evoked by the lemniscal stimulation. Auditory signals ascending from the lemniscal and nonlemniscal thalamic nuclei to the cortical auditory areas appear to be selected or adjusted by a “differential” gating mechanism. Conditioning for associative learning and pseudo-conditioning for nonassociative learning respectively elicit tone-specific and nonspecific plastic changes. The lemniscal, corticofugal and cholinergic systems are involved in eliciting the former, but not the latter. The current article reviews the recent progress in the research of corticocortical and corticofugal modulations of the auditory system and its plasticity elicited by conditioning and pseudo-conditioning.

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Bilateral Cortical Interaction: Modulation of Delay-Tuned Neurons in the Contralateral Auditory Cortex

Cited by 24 publications

References 42 publications

Nonlinear Spectrotemporal Interactions Underlying Selectivity for Complex Sounds in Auditory Cortex

Nonlinear Spectrotemporal Interactions Underlying Selectivity for Complex Sounds in Auditory Cortex

Modulation of auditory processing by cortico-cortical feed-forward and feedback projections

Tuning shifts of the auditory system by corticocortical and corticofugal projections and conditioning

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