Bilateral cortical visual impairment resulting in Anton's syndrome

Pollard, Kendra; Bissonnette, Grace A Brown; Norberg, Stephanie R

doi:10.1111/cxo.13037

Cited by 2 publications

(1 citation statement)

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“…We identified 24 cases of visual deficits without awareness 2,21–41 (visual anosognosia, see Fig 1, Tables S1, S2), 69 cases of visual deficits with awareness, 11 95 cases of motor deficits without awareness (motor anosognosia), and 79 cases of motor deficits with awareness 1 from several sources. The network of voxels connected to each lesion location was computed and the resulting 267 lesion networks were entered into a single voxelwise ANOVA (see Fig 2).…”

Section: Resultsmentioning

confidence: 99%

Network Localization of Awareness in Visual and Motor Anosognosia

Kletenik,

Gaudet,

Prasad

et al. 2023

Annals of Neurology

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ObjectiveUnawareness of a deficit, anosognosia, can occur for visual or motor deficits and lends insight into awareness itself; however, lesions associated with anosognosia occur in many different brain locations.MethodsWe analyzed 267 lesion locations associated with either vision loss (with and without awareness) or weakness (with and without awareness). The network of brain regions connected to each lesion location was computed using resting‐state functional connectivity from 1,000 healthy subjects. Both domain specific and cross‐modal associations with awareness were identified.ResultsThe domain‐specific network for visual anosognosia demonstrated connectivity to visual association cortex and posterior cingulate while motor anosognosia was defined by insula, supplementary motor area, and anterior cingulate connectivity. A cross‐modal anosognosia network was defined by connectivity to the hippocampus and precuneus (false discovery rate p < 0.05).InterpretationOur results identify distinct network connections associated with visual and motor anosognosia and a shared, cross‐modal network for awareness of deficits centered on memory‐related brain structures. ANN NEUROL 2023

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Section: Resultsmentioning

confidence: 99%