Bilateral herpes simplex keratitis reactivation after lacrimal gland botulinum toxin injection

Narang, Purvasha; Singh, Swati; Mittal, Vikas

doi:10.4103/ijo.ijo_904_17

Cited by 10 publications

(2 citation statements)

References 7 publications

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“…HSV reactivation has also been linked to local, systemic, and topical steroid medications including the use of intravitreal triamcinolone injection[ 84 ]. Narang et al [ 85 ] further reported a case of reactivation of HSK after bilateral botulinum toxin injection to manage epiphora[ 85 ]. Ishimaru et al [ 86 ] reported that the HSV-1 virus replicated in host tissue partly due to proteasomal degradation of the Ras-GRF2 factor, while also demonstrating that this can be reversed by the proteasome inhibitor MG132[ 86 ].…”

Section: Understanding the Pathogenesis Of Herpes Simplex Keratitismentioning

confidence: 99%

Herpes simplex keratitis: A brief clinical overview

Musa,

Enaholo,

Aluyi-Osa

et al. 2024

World J Virol

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The aim of our minireview is to provide a brief overview of the diagnosis, clinical aspects, treatment options, management, and current literature available regarding herpes simplex keratitis (HSK). This type of corneal viral infection is caused by the herpes simplex virus (HSV), which can affect several tissues, including the cornea. One significant aspect of HSK is its potential to cause recurrent episodes of inflammation and damage to the cornea. After the initial infection, the HSV can establish a latent infection in the trigeminal ganglion, a nerve cluster near the eye. The virus may remain dormant for extended periods. Periodic reactivation of the virus can occur, leading to recurrent episodes of HSK. Factors triggering reactivation include stress, illness, immunosuppression, or trauma. Recurrent episodes can manifest in different clinical patterns, ranging from mild epithelial involvement to more severe stromal or endothelial disease. The severity and frequency of recurrences vary among individuals. Severe cases of HSK, especially those involving the stroma and leading to scarring, can result in vision impairment or even blindness in extreme cases. The cornea's clarity is crucial for good vision, and scarring can compromise this, potentially leading to visual impairment. The management of HSK involves not only treating acute episodes but also implementing long-term strategies to prevent recurrences and attempt repairs of corneal nerve endings via neurotization. Antiviral medications, such as oral Acyclovir or topical Ganciclovir, may be prescribed for prophylaxis. The immune response to the virus can contribute to corneal damage. Inflammation, caused by the body's attempt to control the infection, may inadvertently harm the corneal tissues. Clinicians should be informed about triggers and advised on measures to minimize the risk of reactivation. In summary, the recurrent nature of HSK underscores the importance of both acute and long-term management strategies to preserve corneal health and maintain optimal visual function.

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Section: Understanding the Pathogenesis Of Herpes Simplex Keratitismentioning

confidence: 99%

Herpes simplex keratitis: A brief clinical overview

Musa,

Enaholo,

Aluyi-Osa

et al. 2024

World J Virol

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“…Описаны случаи возникновения редких осложнений при применении ботулотоксина: острого приступа глаукомы с закрытием угла передней камеры после его введения, что связано с мидриазом, возникшим на фоне парасимпатического воздействия ботулотоксина на ресничный узел [53]; отслойки сетчатки в результате ее перфорации при инъекции [54]; двустороннего кератита при лечении гиперсекреторной функции слезной железы. Авторы рекомендуют проводить тщательный сбор анамнеза перед применением ботулотоксина [55].…”

Section: ботулотоксин в терапии и эстетической медицинеunclassified

Effect of Cosmetic Procedures in the Periorbital Area on the Organ of Vision: Overview

et al. 2018

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Practitioners in ophthalmology in recent years often face the effects of cosmetic procedures on the paraorbital area, as well as directly on the eyelids. Such influences include botox injections in paraorbital area, blepharoplasty, eyelash extensions, injections of various fillers, etc. These manipulations are widely used and often lead to various complications of the vision organ. Eyelash extensions are a popular procedure, especially among urban, young women, but there are potential health risks from the procedure. Tattooing of eyelids leads is the cause of dysfunction of meibomian glands, which can lead to the dry eye syndrome, manifested as complaints about a feeling of chronic discomfort in the eyes. Due to the growing popularity of the age tattoo, it is necessary to pay close attention to the training of specialists who conduct this procedure. The procedure for permanent eyelid make-up should be performed after careful consideration of possible complications, and by special trained professionals. In recent years, various cosmetic procedures for rejuvenating the face plays great role, for example, injections of botulinum toxin, as well as various dermal fillers — the application of which is aimed at eliminating the aging signs. The qualification of the specialist his awareness of the occurrence of possible complications, as well as the awareness of patients who undergo this procedure is an important aspect in the application of botulinum toxin, both for therapeutic and cosmetic purposes. Of great interest are the complications associated with ischemia in the form of soft tissue necrosis and vascular occlusion caused by fillers introduction. It is reported that the frequency of vascular occlusion with dermal fillers is up to 3 per 1000 injections. The only proven elimination of soft tissue ischemia in case of a hyaluronic acid filler use is early high-dose hyaluronidase injections, since this drug helps deactivate the action of hyaluronic acid. Modern ophthalmologic practice is inextricably linked with the latest methods of modern cosmetology medicine, the results of it can effect on the functions of the whole organism as the organ of vision in particular. This fact and the specificity of possible complications arising from cosmetic procedures in the periorbital zone should be taken into account during the anamnesis collecting anamnesis, and examining patients, including preoperative preparation, and in choosing the treatment method.

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Future Perspectives of Botulinum Toxin Application in Dentistry

Etemad‐Moghadam

2020

Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine

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Bilateral herpes simplex keratitis reactivation after lacrimal gland botulinum toxin injection

Cited by 10 publications

References 7 publications

Herpes simplex keratitis: A brief clinical overview

Herpes simplex keratitis: A brief clinical overview

Effect of Cosmetic Procedures in the Periorbital Area on the Organ of Vision: Overview

Future Perspectives of Botulinum Toxin Application in Dentistry

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