Bilateral juvenile open angle glaucoma in two Chinese children: case report

Ng, Larry Hou-Yan; Lung, Jenny Chun-Yee

doi:10.1111/j.1444-0938.2007.00241.x

Clinical and Experimental Optometry

2008

DOI: 10.1111/j.1444-0938.2007.00241.x

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Bilateral juvenile open angle glaucoma in two Chinese children: case report

Larry Hou-Yan Ng

Jenny Chun-Yee Lung

Abstract: Two cases of bilateral juvenile open angle glaucoma (JOAG) in a four-year-old Chinese boy and a 12-year-old Chinese girl are reported.Applanation tonometry revealed elevated intraocular pressure (IOP) in both eyes. The patients were asymptomatic and bilateral open angle glaucoma was confirmed by a paediatric ophthalmologist. One patient had surgery (trabeculectomy), while the other was treated with topical medication. The early detection and treatment of JOAG is essential for the preservation of vision. Tonome… Show more

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Cited by 3 publications

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Bilateral Ocular Hypertension with Rapidly Progressive Optic Neuropathy in a Teen

Hua¹,

Byrne²,

Yudcovitch³

2009

Optometry and Vision Science

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Juvenile-onset Open Angle Glaucoma (JOAG) has been proposed to be a small subset of Primary Open Angle Glaucoma (POAG) and on a continual spectrum of Primary Open Angle Glaucoma. Because most patients with JOAG are asymptomatic, tonometry and optic nerve analysis are crucial in early detection and, thus, must be performed on all patients, young and old. JOAG has a variable onset, with rapidly progressive neuropathy that does not respond well to medical therapy alone, and surgical intervention is often the eventual treatment of choice. Mutations in the myocillin gene have been strongly linked to the disease. JOAG follows an autosomal dominant inheritance with relatively high penetrance. As such, close monitoring, genetics screening, and/or early medical management to prevent irreversible optic neuropathy and blindness should be considered as well for presymptomatic family members.

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Bilateral Ocular Hypertension with Rapidly Progressive Optic Neuropathy in a Teen

Hua¹,

Byrne²,

Yudcovitch³

2009

Optometry and Vision Science

View full text Add to dashboard Cite

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Candidate SNP Markers Significantly Altering the Affinity of the TATA-Binding Protein for the Promoters of Human Genes Associated with Primary Open-Angle Glaucoma

Zolotareva,

Dotsenko,

Podkolodnyy

et al. 2024

IJMS

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Primary open-angle glaucoma (POAG) is the most common form of glaucoma. This condition leads to optic nerve degeneration and eventually to blindness. Tobacco smoking, alcohol consumption, fast-food diets, obesity, heavy weight lifting, high-intensity physical exercises, and many other bad habits are lifestyle-related risk factors for POAG. By contrast, moderate-intensity aerobic exercise and the Mediterranean diet can alleviate POAG. In this work, we for the first time estimated the phylostratigraphic age indices (PAIs) of all 153 POAG-related human genes in the NCBI Gene Database. This allowed us to separate them into two groups: POAG-related genes that appeared before and after the phylum Chordata, that is, ophthalmologically speaking, before and after the camera-type eye evolved. Next, in the POAG-related genes’ promoters, we in silico predicted all 3835 candidate SNP markers that significantly change the TATA-binding protein (TBP) affinity for these promoters and, through this molecular mechanism, the expression levels of these genes. Finally, we verified our results against five independent web services—PANTHER, DAVID, STRING, MetaScape, and GeneMANIA—as well as the ClinVar database. It was concluded that POAG is likely to be a symptom of the human self-domestication syndrome, a downside of being civilized.

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Age, Sex, and Clinical Characteristics of Juvenile Open-Angle Glaucoma Patients in a Saudi Tertiary Hospital: A Retrospective Study of Surgical and Non-Surgical Outcomes

Almulhim,

Almulhim

2024

Medicina

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Background/Objectives: Juvenile Open Angle Glaucoma (JOAG) is a condition that presents peculiar issues because it starts at a very early age and, in the end, causes substantial vision loss. This study aimed to analyze the age and gender distribution and treatment outcomes in JOAG patients. Methods: We carried out a retrospective study at King Abdul Aziz University Hospital, Riyadh, Saudi Arabia, from 2015 to 2022. We extracted data from the medical records. Visual acuity data were converted to the logarithm of the minimum angle resolution (LogMAR) for standardized analysis. The CARL ZEISS Humphrey 745i Field Analyzer/HFA II-i Visual Field Analyzer was used to perform visual field examinations under the 24-2 program SITA standard. Results: The study involved 45 JOAG patients (87 affected eyes) with a mean age of 26.91 years. Myopia was the prevailing trait (93%), and a family history of glaucoma was found in 51.1% of cases. Most of the patients presented with severe visual field defects in both eyes (right—57.1%, left—44.4%). Regarding visual acuity, we found that the majority of affected categories belonged to either mild or moderate in both eyes. Initial and final Intraocular pressure (IOP) measurements together showed a significant reduction (p < 0.001) and clearly demonstrated the need for IOP control. Surgical and non-surgical treatments significantly reduced IOP, with no gender or eye differences Conclusions: This research offers important data concerning JOAG demographics (age and gender), clinical picture, and treatment results. Though early-onset presents challenges, multidimensional therapeutic methods have great potential to get JOAG under control and maintain visual function. Additional research is needed to study the genetic causes of JOAG and assess the long-term treatment outcomes.

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Bilateral juvenile open angle glaucoma in two Chinese children: case report

Cited by 3 publications

References 24 publications

Bilateral Ocular Hypertension with Rapidly Progressive Optic Neuropathy in a Teen

Bilateral Ocular Hypertension with Rapidly Progressive Optic Neuropathy in a Teen

Candidate SNP Markers Significantly Altering the Affinity of the TATA-Binding Protein for the Promoters of Human Genes Associated with Primary Open-Angle Glaucoma

Age, Sex, and Clinical Characteristics of Juvenile Open-Angle Glaucoma Patients in a Saudi Tertiary Hospital: A Retrospective Study of Surgical and Non-Surgical Outcomes

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