Bilateral multifocal central serous retinopathy following mRNA COVID-19 vaccine

Mechleb, Nicole; Khoueir, Ziad; Assi, Alexandre

doi:10.1016/j.jfo.2022.02.001

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…The patient was started on spironolactone, and CSCR resolved at 3 months of follow-up. Similar patients who developed CSCR after COVID-19 vaccination have been recently reported in the literature 67 . The proposed mechanisms contributing to the pathogenesis of CSCR included an increase in endogenous cortisol production.…”

Section: Vitreoretinal Adverse Events To Coronavirus Disease 2019 Vac...supporting

confidence: 74%

“…Similar patients who developed CSCR after COVID-19 vaccination have been recently reported in the literature. 67 The proposed mechanisms contributing to the pathogenesis of CSCR included an increase in endogenous cortisol production. Other proposed mechanisms included free mRNA leading to leaks in the choriocapillaris vessels and an increase in the inflammatory cytokines secondary to an exaggerated immune response to vaccination.…”

Section: Central Serous Chorioretinopathymentioning

confidence: 99%

See 1 more Smart Citation

Update on coronavirus disease 2019: Ophthalmic Manifestations and Adverse Reactions to Vaccination

Lin,

Sen,

Gupta

et al. 2023

Asia-Pacific Journal of Ophthalmology

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The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 was one of the most devastating public health issues in recent decades. The ophthalmology community is as concerned about the COVID-19 pandemic as the global public health community is, as COVID-19 was recognized to affect multiple organs in the human body, including the eyes, early in the course of the outbreak. Ophthalmic manifestations of COVID-19 are highly variable and could range from mild ocular surface abnormalities to potentially sight and life-threatening orbital and neuro-ophthalmic diseases. Furthermore, ophthalmic manifestations may also be the presenting or the only findings in COVID-19 infections. Meanwhile, global vaccination campaigns to attain herd immunity in different populations are the major strategy to mitigate the pandemic. As novel vaccinations against COVID-19 emerged, so were reports on adverse ophthalmic reactions potentially related to such. As the world enters a post-pandemic state where COVID-19 continues to exist and evolve as an endemic globally, the ophthalmology community ought to be aware of and keep abreast of the latest knowledge of ophthalmic associations with COVID-19 and its vaccinations. This review is a summary of the latest literature on the ophthalmic manifestations of COVID-19 and the adverse ophthalmic reactions related to its vaccinations.

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Section: Vitreoretinal Adverse Events To Coronavirus Disease 2019 Vac...supporting

confidence: 74%

Section: Central Serous Chorioretinopathymentioning

confidence: 99%

Update on coronavirus disease 2019: Ophthalmic Manifestations and Adverse Reactions to Vaccination

Lin,

Sen,

Gupta

et al. 2023

Asia-Pacific Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…by various other authors. [12][13][14][15][16][17] Most cases were observed without therapy, and 2 had been prescribed eplerenone. 13,17 Overall, the prognosis was good.…”

Section: Rhegmatogenous Retinal Detachment After Covid-19 Vaccinationmentioning

confidence: 99%

Retinal Detachment Following Vaccination against COVID-19: A Narrative Literature Review

Markov¹,

Zdravkov²,

Oscar³

2023

sjo

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Retinal detachment (RD) refers to the anatomical separation of the neurosensory retina from the Retinal pigment epithelium, which, if untreated, ultimately leads to a loss of visual function and blindness. Three main types are recognised based on the pathogenesis: rhegmatogenous, associated with retinal tears/holes; tractional, where there is pulling on the retina from preretinal and/or vitreal fibrotic changes; and exudative or serous, in which the subretinal fluid is due to transudation, exudation, or impaired outer blood-retina barrier. The infection with SARS-CoV-2 has not been directly associated with any type of RD, except in cases of secondary infections or autoimmune conditions. Serous retinal detachment has very rarely been observed following the application of various vaccines against COVID-19, but only in the setting of central serous chorioretinopathy and uveitis. The single case of purported rhegmatogenous detachment has a highly improbable connection with the vaccination. All in all, the described complications have been extremely uncommon, more frequently treatable or self-resolving, and should not discourage COVID-19 vaccination.

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“…[ 93 ] Recently, few cases of CSC following either COVID-19 or vaccinations such as Pfizer-BioNTech mRNA vaccine, Vaxzevria, and AstraZeneca have been reported. [ 94 95 96 97 ] With the global magnitude of the pandemic, these cases may be incidental, or psychological stress and consequent cortisol surge could be contributory factors. Alternatively, the associated cytokine storm, especially IL-6 surge and coagulopathy, could account for the occurrence of CSC in COVID-19.…”

Section: Cardiovascular Diseases and Central Serous Chorioretinopathymentioning

confidence: 99%

Central serous chorioretinopathy

Jain¹,

Mohan

Dijk

2022

Taiwan Journal of Ophthalmology

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Central serous chorioretinopathy (CSC) has remained an enigmatic disease since its initial description by Von Graefe. Over the years, multiple risk factors have been recognized: these include psychological stress, behavioral traits, and corticosteroids. The basic pathophysiology of CSC involves choroidal thickening, vascular congestion, altered choroidal blood flow (ChBF), and choroidal hyperpermeability, leading to retinal pigment epithelium decompensation and subsequent neurosensory detachment. Multiple organ systems, mainly the nervous, cardiovascular, endocrinal, and renal systems participate in the control of the vascular tone and the ChBF via hypothalamus–pituitary–adrenal axis and renin–angiotensin–aldosterone system, while others such as the hepatic system regulate the enzymatic degradation of corticosteroids. Many vasoactive and psychotropic drugs also modulate the ocular perfusion. In addition, there are anatomical and genetic predispositions that determine its progression to the chronic or recurrent form, through cellular response and angiogenesis. We herein review the basic pathophysiology and immunogenetics in CSC along with the role of multiple organ systems. With this background, we propose an etiological classification that should provide a framework for customized therapeutic interventions.

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Bilateral multifocal central serous retinopathy following mRNA COVID-19 vaccine

Cited by 6 publications

References 16 publications

Update on coronavirus disease 2019: Ophthalmic Manifestations and Adverse Reactions to Vaccination

Update on coronavirus disease 2019: Ophthalmic Manifestations and Adverse Reactions to Vaccination

Retinal Detachment Following Vaccination against COVID-19: A Narrative Literature Review

Central serous chorioretinopathy

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