Bilateral non-contiguous atypical papillary glioneuronal tumor: case report

Flannery, Thomas; Purce, Andrew; Harney, J.; McKinstry, Steven; Ironside, James; Herron, B.

doi:10.5414/np300391

Cited by 6 publications

(6 citation statements)

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“…Of note, the eight tumors with non‐enhancing cyst walls all revealed low Ki‐67 indices (3% or less) . In contrast, among the 12 reported PGNT patients with high Ki‐67 indices, nine had cystic tumors and all tumors demonstrated cyst wall enhancement . These findings suggest that an enhancing cyst wall may correlate with a high proliferative activity of the tumors, and consequently, poorer survival outcomes.…”

Section: Discussionmentioning

confidence: 92%

“…To date, 89 cases of PGNT have been reported in the English literature . Radiologically, most of these cases showed a cystic mass with a mural nodule in the periventricular location.…”

Section: Discussionmentioning

confidence: 99%

“…Although PGNT has been previously reported as a clinically indolent and histologically benign tumor, a few recurrent cases have recently been described . Reports of atypical pathologic findings, including the presence of microvascular proliferation, necrosis and increased proliferative activity, have accumulated . However, minigemistocytes both with or without high proliferative activity have been previously reported .…”

Section: Introductionmentioning

confidence: 99%

“…However, minigemistocytes both with or without high proliferative activity have been previously reported . Moreover, aggressive radiological findings such as multifocal appearance, heterogeneous enhancement with necrosis and marked peritumoral edema have been reported in PGNT cases . However, the relationship among patient characteristics, radiological and pathological findings and prognosis are still unclear, and the optimal therapeutic strategy for PGNT remains uncertain.…”

Section: Introductionmentioning

confidence: 99%

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Papillary glioneuronal tumor with a high proliferative component and minigemistocytes in a child

et al. 2014

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Papillary glioneuronal tumor (PGNT) is a rare type of primary brain tumor. Although PGNT has traditionally been defined as a clinically indolent neoplasm, several cases with high proliferative activity and tumor recurrence have recently been reported. We report a case of PGNT in a 12-year-old boy who presented with epilepsy and harbored a 64 mm cystic tumor with a high proliferative component in the right temporal lobe. (11) C-methionine positron emission tomography (PET) showed high uptake in the solid mass. Gross total resection of the tumor mass was achieved and the patient became seizure-free without any neurological deficits. Histologically, the tumor contained two distinct areas of a vasocentric papilliform structure and a desmoplastic component. Minigemistocytic cells and small necrotic regions were observed adjacent to the pseudopapillae. Immunohistochemical analyses revealed both glial and neuronal differentiation. The Ki-67 proliferation index was high (14%) in the area corresponding to the high uptake region in the (11) C-methionine PET. No tumor recurrence was observed 20 months after surgery. High proliferative PGNTs are rare and to our knowledge this is only the third pediatric case of PGNT with atypical features reported in the literature. Hence, we here review the reported cases of PGNT and discuss the clinical, radiological and histological features of this malignancy.

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Section: Discussionmentioning

confidence: 92%

“…To date, 89 cases of PGNT have been reported in the English literature . Radiologically, most of these cases showed a cystic mass with a mural nodule in the periventricular location.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Papillary glioneuronal tumor with a high proliferative component and minigemistocytes in a child

et al. 2014

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“…Of these, 6 also exhibited vascular proliferation and/or necrosis (2, 4, 8Y10), and 5 recurred after surgery (2Y4, 7) ( Table 1). Secondary lesions of the brain (2, 7) or subdural convexity (7) occurred in 3 cases; 1 very unusual case consisted of bilateral temporal lesions (9). To our knowledge, this is the only case exhibiting systemic metastasis to be reported to date.…”

mentioning

confidence: 88%