Bilateral ocular surface squamous neoplasia with bilateral periocular basal cell carcinoma in a case of xeroderma pigmentosum

Agarwal, Rohit; Chawla, Bhavna; Asif, Mohamed Ibrahime; Pujari, Amar

doi:10.1136/bcr-2017-220882

Cited by 7 publications

(11 citation statements)

References 12 publications

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“…None of our patients had bilateral involvement. Bilateral involvement of OSSN is very rare though very few reports have been found (Usui et al,2004;Grueb et al,2006;Gericke et al, 2008;Masanganise et al, 2010;Agarwal et al, 2017). The most common location of OSSN was nasal limbus similar to other studies (Gichuhi et al, 2015;Dandala et al, 2015a).…”

Section: Discussionsupporting

confidence: 54%

Assessing Profile and Treatment Outcome in Patients of Ocular Surface Squamous Neoplasia (OSSN)

Shrestha¹,

Banstola²,

Man³

et al. 2019

Nep J Oph

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Purpose: This study has attempted to assess the profile and treatment outcome of patients with OSSN and report the recurrence rate following treatment of primary OSSN. Materials and Methods: This was a retrospective, non-comparative hospital based observational study. The case files of OSSN patients from Jan 2010 to Dec 2017were assessed. The study site was Himalaya Eye Hospital, Gharipatan, Pokhara. This hospital is the only eye hospital in province 4, Nepal. All the files of suspicious cases of conjunctival mass or OSSN were reviewed. Data regarding demographic characteristics, vision acuity, involved eye, clinical features, conjunctival lesion type, duration of symptoms, preoperative clinical diagnosis, history, other eye disease, associated systemic diseases, occupation as well as treatment modalities of the patients and its outcome were taken. Results: Out of 40 cases, females were 21(52.5%) vesus 19(47.5%) male. Amongthem, 19 patients had keratinized stratified squamous epithelium, 17 had conjunctiva intraepithelial squamous neoplasia and 4 had invasive squalors cell carcinoma. Predominance age group was 15-59 age (25/40, 62.5%), among which 12 had keratinized stratified squamous epithelium, 11 conjunctival intraepithelial squamousneoplasia and 2 had invasive squamous cell carcinoma conjunctival lesion. The mean duration of symptoms was about nine months (S.D. = 5.972). The mean size of lesion mass was 3.28 mm (SD=1.569). More than half of the cases (55%, 22/40) had the mass located at nasal limbus. 95% (38/40) cases underwent lesion total excision and direct closure and 5% (2/40) underwent lesion excision followed by Amniotic Membrane grafting. Only 5% (2/40) cases, those who had undergone lesion excision, the lesion recurrence was observed during follow up period of 31 months. Conclusion: The outcome of the OSSN following the treatment was found to be satisfactory. Further studies with prolonged follow-up are recommended to evaluate the risk of recurrence and other adverse effects.

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Section: Discussionsupporting

confidence: 54%

Assessing Profile and Treatment Outcome in Patients of Ocular Surface Squamous Neoplasia (OSSN)

Shrestha¹,

Banstola²,

Man³

et al. 2019

Nep J Oph

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“…HIV infection has been associated with younger age at presentation of OSSN [ 31 , 33 ], female or no gender predilection [ 16 , 34 , 35 ], more severe course [ 36 , 37 ], bilaterality [ 38 ], worse prognosis [ 32 ], and increased risk of recurrence [ 39 ]. Immune dysregulation syndromes other than AIDS, including iatrogenic immunosuppression post-organ transplantation [ 39 ], non-Hodgkin’s lymphoma [ 40 ], asthma/eczema/atopic diseases [ 41 – 44 ], ocular cicatricial pemphigoid [ 45 ], xeroderma pigmentosum [ 46 ], and Papillon–Lefèvre syndrome [ 47 ], can also predispose to OSSN.…”

Section: Risk Factors and Pathogenesismentioning

confidence: 99%

Clinical Management of Ocular Surface Squamous Neoplasia: A Review of the Current Evidence

et al. 2018

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Ocular surface squamous neoplasia (OSSN) is the most common non-pigmented malignancy of the ocular surface and is represented in a wide range of histologic diagnoses, ranging from mild epithelial dysplasia to invasive squamous carcinoma. Although surgical excision is still the gold standard for OSSN treatment, interest in conservative medical approaches is steadily growing. We have reviewed all of the literature on OSSN published in English in the MEDLINE database up to May 2018, using the keywords “ocular surface squamous neoplasia,” “squamous conjunctival carcinoma,” and “conjunctival carcinoma in situ,” with the aim to provide a comprehensive review of the most recent evidence on this distinct clinical entity.

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“…4–9 Isolated case reports on bOSSN demonstrate association with HIV, XP, HPV infection, hereditary factors, atopic conjunctivitis, chronic wood dust exposure, ocular cicatricial pemphigoid, neurodermatitis and epidermo-dysplasia verruciformis, and other systemic cancers (Table 1). 10–24 However, literature pertaining to clinical presentation and outcomes of bOSSN is sparse. 10–24 This retrospective series of 25 patients aims to determine the incidence and prevalence, describe the risk factors, clinical presentation, management, and outcomes of bOSSN.…”

Section: Introductionmentioning

confidence: 99%

“…10–24 However, literature pertaining to clinical presentation and outcomes of bOSSN is sparse. 10–24 This retrospective series of 25 patients aims to determine the incidence and prevalence, describe the risk factors, clinical presentation, management, and outcomes of bOSSN.…”

Section: Introductionmentioning

confidence: 99%

Bilateral ocular surface squamous neoplasia: A study of 25 patients and review of literature

Vempuluru

Pattnaik

Ghose

et al. 2021

European Journal of Ophthalmology

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Purpose: To describe the risk factors, clinical presentation, management, and outcomes of patients with bilateral ocular surface squamous neoplasia (OSSN). Methods: Retrospective case series. Results: Of the 25 patients with bilateral OSSN, the mean age at diagnosis of OSSN was 31 years (median, 24 years; range, 2–60 years). Risk factors for bilateral OSSN included xeroderma pigmentosum ( n = 15, 60%), human immunodeficiency virus infection ( n = 3, 12%), conjunctival xerosis ( n = 1, 4%), and topical steroid use ( n = 1, 4%). There were no identifiable ocular or systemic risk factors in 7 (28%) patients. Presentation was synchronous in 14 (56%) and metachronous in 11 (44%) patients. Tumor morphology was bilaterally similar in 12 (48%) patients. Histopathological examination ( n = 36) revealed conjunctival intraepithelial neoplasia (CIN) grade 1 in 4 (8%); grade 2 in 7 (14%); carcinoma in situ in 5 (10%), and invasive carcinoma in 20 (40%). Primary management of OSSN ( n = 49) included excisional biopsy ( n = 31, 62%), topical immunotherapy (IFN α2B) ( n = 11; 22%), topical Mitomycin C (MMC) ( n = 3, 6%), enucleation ( n = 1, 2%), orbital exenteration ( n = 2, 4%), and plaque brachytherapy (PBT) ( n = 1, 2%). One patient was lost to follow-up after detection of tumor in the second eye. Recurrent tumors were noted in 16 (32%) eyes and binocular globe salvage was achieved in 16 (64%) patients at a mean follow up of 41 months (median 30 months; range, 1–164 months). Conclusion: OSSN occurrence can be synchronous or metachronous. Meticulous examination of the fellow eye is important for an early diagnosis of OSSN.

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Bilateral ocular surface squamous neoplasia with bilateral periocular basal cell carcinoma in a case of xeroderma pigmentosum

Cited by 7 publications

References 12 publications

Assessing Profile and Treatment Outcome in Patients of Ocular Surface Squamous Neoplasia (OSSN)

Assessing Profile and Treatment Outcome in Patients of Ocular Surface Squamous Neoplasia (OSSN)

Clinical Management of Ocular Surface Squamous Neoplasia: A Review of the Current Evidence

Bilateral ocular surface squamous neoplasia: A study of 25 patients and review of literature

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