Bilateral polymicrobial osteomyelitis with Candida tropicalis and Candida krusei: a case report and an updated literature review

Kaldau, Niels Christian; Brorson, Stig; Jensen, Poul-Einar; Schultz, Charlotte; Arpi, Magnus

doi:10.1016/j.ijid.2011.10.001

Cited by 14 publications

(15 citation statements)

References 67 publications

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“…Mixed infections with bacteria, as in the present case, especially with Staphylococcus aureus , and non‐ albicans Candida spp have already been described …”

Section: Discussionsupporting

confidence: 74%

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Candida glabrata prosthetic joint infection, successfully treated with anidulafungin: A case report and review of the literature

Koutserimpas

Samonis

Velivassakis

et al. 2018

Mycoses

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Non-albicans Candida prosthetic joint infection (PJI) is extremely rare. A case of a Candida glabrata knee PJI is a 68-year-old splenectomised female smoker, suffering from chronic obstructive pulmonary disease (COPD) and alcoholism is reported. The patient presented with a peri-prosthetic fracture, 15 years after total knee replacement surgery. Cultures of the intraoperative peri-prosthetic tissue and materials yielded C. glabrata, as well as a methicillin-resistant S. epidermitis. The patient was treated with anidulafungin and vancomycin. The knee prosthetic joint was removed and cement-spacer with vancomycin and gentamycin was placed. Additionally, an external fixation was performed. A second stage revision surgery was planned, after completion of the antimicrobial and antifungal treatment. The patient is followed up for 4 months without signs, symptoms or findings of infection. PJI Candida infections require a high clinical suspicion index. It is of utmost importance to report these cases, since there is no consensus yet of the proper antifungal treatment. Furthermore, a literature review regarding treatment of those cases is provided. First-line treatment with an echinocandin seems most proper, due to their fungicidal properties, their effectiveness against biofilm, as well as their minimal toxicity, making them ideal for long-term use. Further experience is needed, for better understanding the disease's pathogenesis and optimal treatment.

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“…Mixed infections with bacteria, as in the present case, especially with Staphylococcus aureus , and non‐ albicans Candida spp have already been described …”

Section: Discussionsupporting

confidence: 74%

“…[7][8][9] Mixed infections with bacteria, as in the present case, especially with Staphylococcus aureus, and non-albicans Candida spp have already been described. 1,10 Early diagnosis and choice of appropriate treatment, based on cul- and the long duration of symptoms before diagnosis and treatment, as in the present patient. 11…”

Section: Discussionmentioning

confidence: 84%

Candida glabrata prosthetic joint infection, successfully treated with anidulafungin: A case report and review of the literature

Koutserimpas

Samonis

Velivassakis

et al. 2018

Mycoses

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“…Fifty-seven percent of patients underwent a combination of surgical and antifungal therapy with therapy reported to be successful in 88% [5], [6], [7].…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of Candida tropicalis osteomyelitis with Micafungin in a leukemia patient

Tong

Ruan

et al. 2016

IDCases

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“…Hastanın muayenesinde sol el 4. parmak dorsal yüz distal interfalangeal eklem seviyesinde, 1 cm çapında, fibrinli açık yara, ulnar tarafta 1,5 cm çaplı, tabanı nekroze ve eklem yapısının gözlendiği pürülan akıntı vardı. Laboratuvar incelemelerinde HbA1c: %12,1 (4,5-6), C-reaktif protein (CRP): 0,04 mg/dl (<0,5), eritrosit sedimentasyon hızı (ESR): 6 mm/ saat (0-20) ve beyaz küre: 9,62x10 3 /µl (4,(8)(9)(10)8)…”

Section: Olguunclassified

“…Etken olarak en sık Candida albicans görülür, ancak son yıllarda non-albicans Candida'ların da osteomiyelitlerde sıklığının arttığı bildirilmektedir [7,9,10] . Güncel kılavuz önerilerinde, cerrahi ve uzun süreli antifungal (en az 6 ay) tedavi ile başarılı sonuçlar elde edilebildiği bildirilmektedir [3,7,11] .…”

Section: Introductionunclassified

Osteoarticular Candida Infection: Case Reports and Literature Review

Aksoy¹,

Aydın²,

Ertuğrul³

et al. 2019

mjima

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Funguslara bağlı kemik eklem enfeksiyonları nadirdir. Kandida türlerine bağlı osteomiyelit de oldukça nadir görülen bir durumdur. Etken olarak en sık Candida albicans görülür, ancak son yıllarda non-albicans Candida'ların da osteomiyelitlerde sıklığının arttığı bildirilmektedir. Bu yazıda nonalbicans Candida osteomiyeliti olan üç olgu sunuldu. Osteoartiküler tutuluma bakıldığında olguların birinde lomber vertebra, birinde el, diğerinde ise ayak osteomiyeliti vardı. Olguların üçünde diabetes mellitus ve uzun süreli antibiyotik kullanımı ortak risk faktörleriydi. Vertebral osteomiyelit olan olguda ayrıca cerrahi girişim ve yabancı cisim varlığı diğer risk faktörleriydi. Olguların tanısında manyetik rezonans görüntüleme kullanıldı ve alınan derin doku kültüründe etken izole edildi. Tüm olgulara cerrahi debritman yapılarak altı hafta ile 24 hafta arasında değişen sürede antifungal tedavi verildi. Olgularda klinik ve radyolojik takiplerde enfeksiyon tekrarlamadı. Ayağında osteomiyeliti olan olgu akut serebrovasküler hastalık nedeni ile eksitus oldu. Çalışmamızda Nisan 2010-Haziran 2019 tarihleri arasında osteoartiküler Candida enfeksiyonu ile ilgili literatür taraması yapıldı ve 44 olgu derlendi. Çalışmamızda bu olguları sunmadaki amacımız, kandidaya bağlı osteoartiküler enfeksiyonlara dikkati çekmek ve etken tanımlanmasıyla hedefe yönelik tedavinin önemini vurgulamaktır. Anahtar Kelimeler: Spondilodiskit, flukonazol, kaspofungin, sistematik derleme, lipozomal amfoterisin b Fungal infections in the bones and joints are rare. Candida spp. osteomyelitis is also a very rare entity. The most common pathogen is Candida albicans, but an increase in the incidence of non-albicans Candida osteomyelitis has been reported in recent years. Herein, we present three patients with non-albicans Candida osteomyelitis. Osteoarticular involvement occurred in the lumbar vertebrae in one patient, in the hand in one patient, and the foot in the other patient. Diabetes mellitus and long-term antibiotic use were common risk factors in all three cases. In the patient with vertebral osteomyelitis, surgical intervention and foreign body were other risk factors. Magnetic resonance imaging was used in the diagnosis and the pathogens were isolated from deep tissue cultures. Surgical debridement was performed in all cases and antifungal treatment was given for 6-24 weeks. There was no reinfection or relapse during clinical and radiological follow-up. The patient with osteomyelitis of the foot died due to to acute cerebrovascular disease. In our study, the literature review for publications related to osteoarticular Candida infection was made between April 2010 and June 2019 and 44 cases are reviewed. Our aim in this study was to draw attention to Candida osteoarticular infections and to emphasize the importance of targeted treatment by defining the pathogen.

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Bilateral polymicrobial osteomyelitis with Candida tropicalis and Candida krusei: a case report and an updated literature review

Cited by 14 publications

References 67 publications

Candida glabrata prosthetic joint infection, successfully treated with anidulafungin: A case report and review of the literature

Candida glabrata prosthetic joint infection, successfully treated with anidulafungin: A case report and review of the literature

Successful treatment of Candida tropicalis osteomyelitis with Micafungin in a leukemia patient

Osteoarticular Candida Infection: Case Reports and Literature Review

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