Bilateral Posterior Ischemic Optic Neuropathy Associated With Use of Sildenafil

Su, Dongdong; Ang, Pei San; Tow, Sharon Lee-Choon

doi:10.1097/wno.0b013e318167554a

Cited by 17 publications

(6 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to these clinical settings, there also are reports of PION associated with use of sildenafil (2), and Wegener disease (3). The imaging findings in PION have been previously documented, and include restricted diffusion on DWI similar to our case (4)(5)(6)(7).…”

supporting

confidence: 70%

Posterior Ischemic Optic Neuropathy in the Setting of Posterior Reversible Encephalopathy Syndrome and Hypertensive Emergency

Joos

Adesina

Katz

2014

Journal of Neuro-Ophthalmology

View full text Add to dashboard Cite

show abstract

supporting

confidence: 70%

Posterior Ischemic Optic Neuropathy in the Setting of Posterior Reversible Encephalopathy Syndrome and Hypertensive Emergency

Joos

Adesina

Katz

2014

Journal of Neuro-Ophthalmology

View full text Add to dashboard Cite

show abstract

“…According to the authors, the patient had bilateral disc-at-risk appearance. In the second case, the patient experienced bilateral posterior NAION after a megadose of sildenafil; he also had a history of systemic hypertension, lipidemia and stroke [6]. To the best of our knowledge, ours is the first reported case of bilateral simultaneous NAION in a patient without prior medical history or other ischemic stigmata.…”

Section: Discussionmentioning

confidence: 98%

Bilateral Simultaneous Anterior Ischemic Optic Neuropathy Associated with Sildenafil

Moschos

Margetis²

2011

Case Rep Ophthalmol

View full text Add to dashboard Cite

We report a case of simultaneous bilateral nonarteritic anterior ischemic optic neuropathy (NAION) due to sildenafil use. A 55-year-old man with an unremarkable medical history presented simultaneous bilateral NAION 8 months after continuous use of sildenafil 4–5 times a month. At presentation, visual acuity (VA) was 0.7 in the right eye (RE) and 0.9 in the left eye (LE). The visual field showed an inferior altitudinal defect in both eyes and a fundus examination revealed prominent optic disc edema in the RE and a crowded optic disc in the LE. The patient was counseled to discontinue sildenafil, and 3 weeks later VA was 1.0 in both eyes and the optic disc edema in the RE was resolved. However, a visual field defect remained in the RE. Three months later, visual fields were unchanged. To the best of our knowledge, this is the first reported case of simultaneous bilateral NAION due to sildenafil use.

show abstract

“…It is more common in Caucasians than in African, American, and Hispanic descendants. NAION is a multifactorial disorder [30] and is believed to be related to vascular insufficiency in the optic nerve head. The condition is also associated with short posterior ciliary artery dysfunction.…”

Section: Epidemiology and Pathophysiologymentioning

confidence: 99%

Phosphodiesterase Type 5 Inhibitors and Visual Side Effects: A Narrative Review

Barroso

Ribeiro

Miranda

2021

JOVR

View full text Add to dashboard Cite

Phosphodiesterase type 5 inhibitors such as sildenafil citrate and tadalafil are well known for the treatment of erectile dysfunction. However, their use in the presence of pulmonary hypertension can cause ophthalmologic side effects, including non-arteritic optic ischemic neuropathy, chorioretinopathy, glaucoma, and optic atrophy. The present review aimed to identify these visual side effects and provide recommendations. We identified articles published from January 2000 to March 2019 on diseases arising from the management of sexual dysfunction in urology or pulmonary hypertension in pneumonia that could cause pathologic alterations in eye structure based on a literature search of the MEDLINE electronic database using keywords for the most common adverse effects and different kinds of phosphodiesterase 5 inhibitors. After applying the exclusion criteria, we selected 36 of the 77 articles initially identified to write the narrative review and added 20 additional articles to completely describe the pathological entities. Phosphodiesterase type 5 inhibitors can cause side effects in the eye including ocular surface abnormalities, increased intraocular pressure and glaucoma, uveitis, non-arteritic ischemic neuropathy, chorioretinopathy, retinal occlusion, and visual field changes. There is an increased need for well-performed studies to better understand these side effects, which are common due to the wide use of sildenafil.

show abstract

Bilateral Posterior Ischemic Optic Neuropathy Associated With Use of Sildenafil

Cited by 17 publications

References 3 publications

Posterior Ischemic Optic Neuropathy in the Setting of Posterior Reversible Encephalopathy Syndrome and Hypertensive Emergency

Posterior Ischemic Optic Neuropathy in the Setting of Posterior Reversible Encephalopathy Syndrome and Hypertensive Emergency

Bilateral Simultaneous Anterior Ischemic Optic Neuropathy Associated with Sildenafil

Phosphodiesterase Type 5 Inhibitors and Visual Side Effects: A Narrative Review

Contact Info

Product

Resources

About