Bilateral renal involvement in diffuse large B-cell lymphoma on fluorodeoxyglucose positron emission tomography/computed tomography

Benameur, Yassir; Hammani, Adnane; Doghmi, Kamal; Doudouh, A.

doi:10.4103/wjnm.wjnm_111_20

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…The most common findings on a CT scan are multiple soft tissue masses, ranging from 1-3 cm, with minimal enhancement after contrast compared to the surrounding renal parenchyma (6). 18 F-FDG PET/CT is considered the gold standard for response assessment (7). As in the reported case, renal involvement in lymphoma was not identified by a conventional CT scan, but it was diagnosed with the help of a PET/CT scan.…”

Section: Case Reportmentioning

confidence: 67%

Bilateral Renal Lymphoma Detected by F-18 FDG PET/CT scan: A Case Report

Sajjad Al Mishal,

Akhter,

Mutsuddy

et al. 2024

Bangladesh J. Nuclear Med.

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Diffuse large B-cell lymphoma (DLBCL) is the commonest subtype of non-Hodgkin’s lymphoma (NHL) and constitutes 25% of all NHL cases. Extranodal involvement includes the gastrointestinal, head and neck, orbital, central and peripheral nerve systems, thorax, bone, skin, breast, testis, thyroid, and genitourinary systems in 25-40% of HL patients, particularly NHL patients. Renal involvement in lymphoma is commonly seen in cases of widespread nodal or extranodal lymphoma, which is known as secondary renal lymphoma (SRL). This reported case of SRL was a known DLBCL patient. A young woman of 19 years diagnosed with DLBCL visited the PET-CT division of National Institute of Nuclear Medicine & Allied Sciences (NINMAS) for a18F-FDG PET-CT study to assess therapeutic response, metabolic characterization and staging. Post-chemotherapy abdominal CT and ultrasound were normal. However, 18F-FDG PET-CT revealed metabolically active lymphoma involving cervical, mediastinal, and abdominal lymph nodes, but unusual bilateral renal involvement modified the therapeutic management eventually. Bangladesh J. Nuclear Med. 26(2): 229-232, 2023

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Section: Case Reportmentioning

confidence: 67%

Bilateral Renal Lymphoma Detected by F-18 FDG PET/CT scan: A Case Report

Sajjad Al Mishal,

Akhter,

Mutsuddy

et al. 2024

Bangladesh J. Nuclear Med.

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“…These genes were associated with various pathways and pathologies including but not limited to chemokine, toll-like receptor, NK cell signaling, myocarditis, and apoptosis pathways. Expression of these genes was indicated with onset, progression, severity, and spread to other organs [7]. Renal involvement was associated with worse progression of lymphomas [8].…”

Section: Discussionmentioning

confidence: 99%

Coexistence of Diffuse Large B-Cell Lymphoma With Chronic Tubulointerstitial Nephritis: A Case Review and Pathophysiology

Zuhdi,

Khatskevich,

Riemer

2024

Cureus

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There is an association between lymphomas and kidney disease with renal abnormalities found both in patients with direct infiltration by lymphoma as well as in patients without gross or microscopic evidence of renal involvement. Multiple mechanisms to explain the link between lymphomas and renal disease have been proposed, ranging from direct renal metastasis by the lymphoma to chemokine signaling pathways. In addition, there is a correlation between certain genetic mutations and an increased risk of lymphoma metastasizing to other organs. We present a case of a 41-year-old male who passed away due to end-stage kidney disease and was found on autopsy to have chronic tubulointerstitial nephritis and diffuse large B-cell lymphoma (DLBCL) without direct renal involvement by the lymphoma. The patient had been previously healthy with no significant prior medical history, NSAID, or other contributory medication use of note with the only presenting symptom being renal failure. Only upon autopsy was DLBCL discovered throughout the abdomen with no direct lymphoma involvement evident in the kidneys. To the author's knowledge, this is one of the few reported cases of DLBCL in English literature without renal infiltration in which the presenting symptom and cause of death was renal dysfunction. Several mechanisms have been theorized for how lymphomas can lead to kidney damage without direct metastasizes; however, more research still needs to be done to better understand the underlying etiology. Given the rarity and the lack of direct infiltration of lymphoma into the kidneys in this patient, we hope reporting this case will allow further advancements in this field of study as well as more comprehensive management.

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