Bilateral sciatic neuropathy with severe rhabdomyolysis following venlafaxine overdose

Ko, Jae Ung; Seo, Hyeunsuk; Lee, Goo Joo; Park, Donghwi

doi:10.1097/md.0000000000012220

Cited by 6 publications

(7 citation statements)

References 10 publications

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“…In-depth research is warranted to investigate the mechanism of venlafaxine-associated rhabdomyolysis and to reliably estimate the risk of rhabdomyolysis in individuals receiving venlafaxine. Liu et al 4 0 +2 +1 0 +2 0 0 0 0 0 5 Torner et al 5 0 +2 +1 0 +2 0 0 0 0 0 5 Huang et al 6 0 +2 +1 0 +2 0 0 0 0 0 5 Rajapakse et al 7 0 +2 +1 0 +2 0 0 0 0 0 5 Lu et al 8 0 +2 +1 0 +2 0 0 0 0 0 5 Hanekamp et al 9 0 +2 +1 0 +2 0 +1 0 0 0 6 Pascale et al 10 0 +2 +1 0 +2 0 +1 0 0 0 6 Oliver et al 11 0 +2 +1 0 +2 0 +1 0 0 0 6 Oliver et al 11 0 +2 +1 0 0 0 +1 0 0 0 4 Ko et al 12 0 +2 +1 0 +2 0 +1 0 0 0 6 Batista et al 13 0 +2 +1 0 +2 0 +1 0 0 0 6 Batista et al 13 0 +2 +1 0 +2 0 +1 0 0 0 6…”

Section: Discussionmentioning

confidence: 99%

“…Venlafaxine was administered orally in all cases. Of the 12 patients, 5 patients received venlafaxine at doses of ≤225 mg/d (cases 1-5), whereas the remaining 7 patients received doses exceeding 225 mg/d (cases [6][7][8][9][10][11][12]. Seven patients received venlafaxine as monotherapy, 4 patients received it in combination with another drug, and 1 patient received it in combination with 3 other drugs.…”

Section: Venlafaxine Usementioning

confidence: 99%

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Venlafaxine-Associated Rhabdomyolysis

Ren,

Wang,

Nie

et al. 2024

J Clin Psychopharmacol

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Purpose This systematic review aimed to investigate the clinical manifestations and characteristics of venlafaxine-associated rhabdomyolysis. Methods A systematic search was conducted in PubMed, Elsevier, Science Direct, Embase, Springer Link, Wiley Online Library, CNKI, and Wanfang databases from the date of database inception to January 2023. Previously reported cases of venlafaxine-associated rhabdomyolysis were identified, and relevant data from these cases were collected for descriptive statistical analysis. Cases that met the inclusion criteria were evaluated to determine the correlation between adverse reactions and venlafaxine. Results A total of 12 patients with venlafaxine-associated rhabdomyolysis were included. None of these patients had a history of muscle pain or discomfort. Of the 12 patients, 5 patients received venlafaxine at doses of ≤225 mg/d, whereas the remaining 7 patients received doses exceeding 225 mg/d. The main clinical symptoms included myalgia, muscle weakness, and renal injury. All 12 patients discontinued venlafaxine and received symptomatic care. Conclusions Venlafaxine, used either as a monotherapy or in combination with other drugs, may be associated with rhabdomyolysis. Creatine kinase levels may normalize or significantly decrease after discontinuation of venlafaxine and symptomatic treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Venlafaxine Usementioning

confidence: 99%

Venlafaxine-Associated Rhabdomyolysis

Ren,

Wang,

Nie

et al. 2024

J Clin Psychopharmacol

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“…The treatment of sciatic neuropathy is generally medication specific to the pain, such as tricyclics, anticonvulsants, and topical analgesia. [3] In some cases, a simple combination of anti-inflammatory medication and mild exercise may also be prescribed. However, treatment of sciatic neuropathy solely with medication often leads to unsatisfactory outcome.…”

Section: Discussionmentioning

confidence: 99%

“…[1] Compressive sciatic neuropathy can be a result of various conditions, including mass lesion, trauma, gluteal hematoma, or compartment syndrome. [2,3]…”

Section: Introductionmentioning

confidence: 99%

Isolated injury to the tibial division of sciatic nerve after self-massage of the gluteal muscle with massage ball

et al. 2019

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Introduction: An isolated injury to the tibial division is rare among compressive sciatic neuropathy. To date, isolated injury to the tibial division of the sciatic nerve after self-massage of the gluteal muscle has not been reported. Here, we report a case of compressive sciatic neuropathy diagnosed after self-massage of the gluteal muscle using magnetic resonance image (MRI) and ultrasound images and its associated therapeutic process. Patient concerns: A 50-year-old woman presented right lower extremity pain for the past 7 days. Diagnosis: Electrophysiological findings were consistent with right tibial neuropathy proximal to the branch to hamstring muscles. However, T2-weighted MRI showed high signal intensity and swelling in the right sciatic nerves from the superior gemellus level to the quadratus femoris level. After considering both radiologic and electrophysiological findings, the patient was diagnosed with an isolated injury to the tibial division of the right sciatic nerve. Interventions: The patient agreed to an ultrasound-guided perineural steroid injection upon receiving detailed explanation of the procedure. Outcomes: After the injection, there was significant improvement in pain. Conclusion: Therefore, in making a diagnosis of sciatic neuropathy, it may be important to find the lesion via MRI than relying solely on the patient's history or electrophysiologic study.

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“…According to various authors, venlafaxine should be recommended for use in primary care as a second-line option following the treatment with selective serotonin reuptake inhibitors (Thase et al, 2017;Schueler et al, 2011). Similar to other antidepressants, venlafaxine has manifested a number of moderate collateral symptoms such as fatigue, nausea, somnolence, or mild gastrointestinal problems; however, eventually, the drug can lead to more serious problems, which include severe lactic acidosis, interstitial pneumonitis, neuropathy, different forms of adult and prenatal cardiomyopathy, as well as liver and kidney affections (Paulis et al, 2018;Ko et al, 2018).…”

Section: Acute Genotoxic Assaymentioning

confidence: 99%

Genotoxic and cytotoxic evaluation of venlafaxine in an acute and a subchronic assay in mouse

et al. 2024

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The present research was made to determine the micronuclei and cytotoxic capacity of the antidepressant venlafaxine in an in vivo acute and subchronic assays in mouse. In the first study, we administered once 5, 50, and 250 mg/kg of the drug, and included a negative and a daunorubicin treated group. Observations were daily made during four days. The subchronic assay lasted 5 weeks with daily administration of venlafaxine (1, 5, and 10 mg/kg) plus a negative and an imipramine administered groups. Observations were made each week. In the first assay results showed no micronucleated polychromatic erythrocytes (MNPE) increase, except with the high dose at 72 h. The strongest cytotoxic effect was found with 250 mg/kg at 72 h (a 51% cytotoxic effect in comparison with the mean control level). In the subchronic assay no MNPE increase was found; however, with the highest dose a significant increase of micronucleated normochromatic erythrocytes was observed in the last three weeks (a mean of 51% respect to the mean control value). A cytotoxic effect with the two high doses in the last two weeks was observed (a polychromatic erythrocyte mean decrease of 52% respect to the mean control value). Results suggest caution with venlafaxine.

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Bilateral sciatic neuropathy with severe rhabdomyolysis following venlafaxine overdose

Cited by 6 publications

References 10 publications

Venlafaxine-Associated Rhabdomyolysis

Venlafaxine-Associated Rhabdomyolysis

Isolated injury to the tibial division of sciatic nerve after self-massage of the gluteal muscle with massage ball

Genotoxic and cytotoxic evaluation of venlafaxine in an acute and a subchronic assay in mouse

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