Bilateral upper limb compartment syndrome induced by strenuous exercise in a patient with haemophilia A and a low titre inhibitor

Abdelhalim, Mohamed Ahmed; Shaw, C.; Al-Rub, Z. Abu; Hopper, David; Hanley, John; Talks, Kate; Biss, Tina; Fearon, P.

doi:10.1111/hae.12783

Cited by 3 publications

(4 citation statements)

References 7 publications

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“…Pro‐ and anti‐coagulant clotting abnormalities are also associated with ALCS, including spontaneous haemorrhage from haemophilia, factor deficiencies and haematological malignancy. 11 , 18 , 19 , 20 , 21 , 22 Platelet deficiency or dysfunction also causes ALCS, and has been reported with human immunodeficiency virus. 23 , 24 Extreme thrombocytosis may also cause spontaneous haemorrhage leading to compartment syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…7 Muscle necrosis can develop within 3 h of injury, and permanent functional deficit rises when fasciotomy is delayed more than 12 h from the onset of symptoms. [8][9][10][11] Delayed treatment can lead to contracture, fibrosis, stiffness, sensory disturbances, muscle excision, amputation and mortality. 3 Up to 77% of cases of ALCS are associated with a fracture; however, it also occurs following burns, vascular injury, prolonged immobilisation, infection and haematologic disorders.…”

Section: Introductionmentioning

confidence: 99%

“…7 Muscle necrosis can develop within 3 h of injury, and permanent functional deficit rises when fasciotomy is delayed more than 12 h from the onset of symptoms. 8 , 9 , 10 , 11 Delayed treatment can lead to contracture, fibrosis, stiffness, sensory disturbances, muscle excision, amputation and mortality. 3 …”

Section: Introductionmentioning

confidence: 99%

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Review article: A comprehensive review of unusual causes of acute limb compartment syndrome

Steadman

Hamilton

et al. 2022

Emerg Medicine Australasia

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Acute limb compartment syndrome (ALCS) is a surgical emergency that can have serious consequences unless promptly diagnosed and treated, which is particularly challenging when there is an unusual cause. This is a comprehensive review of reported causes of ALCS. From 1068 included articles, we found 299 discrete causes of ALCS including toxins, infections, endocrine pathology, haematological emergencies, malignancy and iatrogenic ALCS. Familiarity with this wide range of ALCS causes may assist in early diagnosis of this limb-threatening condition.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Review article: A comprehensive review of unusual causes of acute limb compartment syndrome

Steadman

Hamilton

et al. 2022

Emerg Medicine Australasia

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“…The easy tendency to bleeding is related to the presence of inhibitor and, obviously, to lack of prophylaxis with factor VIII 25. In 2016 Niblock et al reported two cases of ACS as the first clinical sign to suspect hemophilia.…”

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confidence: 99%

The Risk of Venipuncture in Newborn with Severe Hemophilia: Case Report of a Large Elbow Hemorrhage and Literature Review of Compartment Syndrome

et al. 2021

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Hemophilias are hemorrhagic congenital rare diseases. The gold standard of therapy in hemophilics is the intravenously replacement therapy. We can infuse intravenously plasma derived factors (FVIII for Hemophilia A and FIX for Hemophilia B) or recombinant products (i.e. clotting factor synthetically produced). Venipuncture is not a safe procedure in subjects with hemorrhagic diseases. It is considered an invasive technique with potential massive bleeding and it requires standardized procedures to prevent complications. Local pressure after the procedure (with eventually ice rest) must be always done. In case of bleeding a rapid replacement therapy must be conducted. A severe complication in hemophilia is compartment syndrome. We report a case of massive bleeding in a hemophilic newborn after venipuncture and a literature review of compartment syndrome in hemophiliacs. The aim of this paper is to help physicians in the clinical management to prevent the evolution of a massive bleeding in compartment syndrome.

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Acute Compartment Syndrome After Knee Synovectomy in a Patient with Hemophilia A

Baghdadi

Firoozabadi

et al. 2019

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Case: A 19-year-old man with severe hemophilia A underwent open surgical synovectomy to treat recurrent hemarthrosis of the knee. He developed symptoms and signs of acute compartment syndrome (ACS) despite receiving full-dose factor replacement. Arthrotomy was performed twice, and massive hemarthrosis was evacuated. The symptoms subsided after supplementing clotting factor with prednisone. Conclusions: ACS may complicate hemophilia. Diagnosis is mainly based on clinical judgment. Proper factor replacement is the mainstay of treatment. Surgery is reserved for patients with no improvement following factor administration.

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Bilateral upper limb compartment syndrome induced by strenuous exercise in a patient with haemophilia A and a low titre inhibitor

Cited by 3 publications

References 7 publications

Review article: A comprehensive review of unusual causes of acute limb compartment syndrome

Review article: A comprehensive review of unusual causes of acute limb compartment syndrome

The Risk of Venipuncture in Newborn with Severe Hemophilia: Case Report of a Large Elbow Hemorrhage and Literature Review of Compartment Syndrome

Acute Compartment Syndrome After Knee Synovectomy in a Patient with Hemophilia A

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