Bildgebende Verfahren

Félix, R.; Langer, Ruth; Langer, M.

doi:10.1007/978-3-642-77783-7_2

Cited by 1 publication

(1 citation statement)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our patients, tracer began to accumulate in the gall bladder 18 min after tracer injection, which corresponds to standard values mentioned in the literature, with excretion phases starting after 15 to 30 min [ 12 ]. On account of its small organ size, activity in the gall bladder never exceeds 2.3% of the injected dose up to a time point of 60 min, which is similar to previous analyses [ 4 ], but shows increasing SUV max up to 48.3% after 60 min due to tracer accumulation and concentration.…”

Section: Discussionsupporting

confidence: 78%

Liver PET Reloaded: Automated Synthesis of [68Ga]Ga-BP-IDA for Positron Imaging of the Hepatobiliary Function and First Clinical Experience

et al. 2023

View full text Add to dashboard Cite

Hepatobiliary scintigraphy is a well-established nuclear imaging method for evaluating liver function and displaying the biliary system, but the spatial and temporal resolution is limited, and, there is still no established PET equivalent. Adapted from the work of Schuhmacher et al. in 1983, the production of a 68Gallium-labeled substitute, tetrabromophthalein ([68Ga]Ga-BP-IDA), was undertaken according to current Good Manufacturing Practice (GMP) standards and proved feasible and reproducible. PET/CT with the radiotracer was performed in two complex patients with hepatocellular carcinoma in preparation for transarterial radioembolization. Due to its high spatial and temporal resolution, localization of areas with impaired liver function and visualization of the biliary system were possible. We could demonstrate that this 68Gallium-labeled, IDA-based PET tracer is feasible and could advance hepatic and biliary function PET imaging.

show abstract

Section: Discussionsupporting

confidence: 78%