Bile Acids and Other Lipids in the Gall-Bladder Biles of Africans with Primary Cancer of the Liver

Mirvish, Sidney S.

doi:10.1038/bjc.1964.53

Cited by 4 publications

(1 citation statement)

References 6 publications

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“…Consistent differences between normal bile and bile from patients with cholesterol gallstones have been difficult to demonstrate (9)(10)(11)(12)(13)(14)(15)(16)(17). Although some of this difficulty is due to differences in the analytical methods used, some confusion may have arisen from the way in which the data have been expressed.…”

Section: Introductionmentioning

confidence: 99%

The physicochemical basis of cholesterol gallstone formation in man

Admirand¹,

Small²

1968

J. Clin. Invest.

1,012

332

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A B S T R A C T The concentrations of bile, salt, lecithin, and cholesterol were determined on each of 66 samples of gall bladder bile from patients with cholesterol gallstones and 25 samples of normal gall bladder bile. When these three constituents were plotted simultaneously on triangular coordinates, a complete separation of the normal and "abnormal" bile was achieved. This separation was the result of an increase in the quantity of cholesterol relative to the amounts of bile salts and lecithin contained in the bile from patients with cholesterol gallstones. An in vitro model system was constructed (on triangular coordinates) that allows prediction of the maximum amount of cholesterol that can be solubilized in solutions containing varying proportions of bile salt and lecithin. When the bile data were compared with the solubility of cholesterol derived from the model system, normal biles were found to be less than saturated with cholesterol, whereas biles from patients with cholesterol gallstones were saturated and in some cases contained insoluble cholesterol in the form of microcrystals.It is suggested that the physical state of bile (i.e., the presence or absence of insoluble cholesAn abstract of this work has appeared in 1967 J. Clin.

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Section: Introductionmentioning

confidence: 99%