2021
DOI: 10.3389/fchem.2021.753990
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Bile Acids Gate Dopamine Transporter Mediated Currents

Abstract: Bile acids (BAs) are molecules derived from cholesterol that are involved in dietary fat absorption. New evidence supports an additional role for BAs as regulators of brain function. Sterols such as cholesterol interact with monoamine transporters, including the dopamine (DA) transporter (DAT) which plays a key role in DA neurotransmission and reward. This study explores the interactions of the BA, obeticholic acid (OCA), with DAT and characterizes the regulation of DAT activity via both electrophysiology and … Show more

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Cited by 6 publications
(10 citation statements)
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“…To investigate the dependency of the amplitude of the I’ OCA on DA doses, we tested the concentration of DA 2 μM, proximal to the K 0.5 for mDAT ( Sonders et al, 1997 ; Romanazzi et al, 2021 ), after the first exposure to OCA. The second application of OCA 10 μM elicited a detectable I’ OCA , but with a significantly reduced amplitude (40% of I 0 OCA ) ( p < 0.0001).…”
Section: Resultsmentioning
confidence: 99%
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“…To investigate the dependency of the amplitude of the I’ OCA on DA doses, we tested the concentration of DA 2 μM, proximal to the K 0.5 for mDAT ( Sonders et al, 1997 ; Romanazzi et al, 2021 ), after the first exposure to OCA. The second application of OCA 10 μM elicited a detectable I’ OCA , but with a significantly reduced amplitude (40% of I 0 OCA ) ( p < 0.0001).…”
Section: Resultsmentioning
confidence: 99%
“…(B) Data from 14/3 n/N were fitted to Hill’s equation and the data reported in table (C) . *Parameter for the DA reported in Romanazzi et al (2021) . (D) Data from 11/2 n/N cells perfused with increasing concentrations of NE from 3 μM to 1 mM with or without OCA, 10 μM, were fitted to Hill’s equation and the data reported in table (left) and (right) data from 9/2 n/N cells perfused with increasing concentrations of 5-HT from 3 μM to 1 mM with or without OCA 10 μM were fitted to Hill’s equation and the data reported in the table (NE: I max : p = 0.9435; K 0.5 : p = 0.8341; 5-HT: I max : p = 0.7259; K 0.5 : p = 0.8730).…”
Section: Resultsmentioning
confidence: 99%
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“…Of the nine differential metabolites identified in this study, there were several different species of bile acids, including cholic acid, allolithocholic acid, and deoxycholic acid 3-glucuronide. Bile acids readily cross the blood–brain barrier and their receptors are expressed in central tissues, suggesting that they may have important functional roles ( Romanazzi et al, 2021 ). The bile acid signaling pathway plays an extremely important role in diseases and is a target for drug intervention.…”
Section: Discussionmentioning
confidence: 99%