Bile acids increase response and expression of human myometrial oxytocin receptor

Germaín, A; Kato, Sumie; Carvajal, Jorge; Valenzuela, Guillermo J.; Valdés, Gloría; Glasinovic, J C

doi:10.1067/s0002-9378(03)00545-3

Cited by 125 publications

(93 citation statements)

References 17 publications

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“…The increase in complications noted in the study correlate well with the findings of similar studies [2] [3] [15]- [17]. Postpartum hemorrhage and placental abruption showed the greatest increase in those with ICP, with roughly a 10 fold increase over those who had pruritus in the absence of ICP [18]. The Increase in bleeding manifestations such as PPH is well recognized [15] [19] and is thought to occur as a result of subclinical steatorrhea associated with ICP resulting in reduced absorption of vitamin K [20] [21].…”

Section: Discussionsupporting

confidence: 80%

“…Studies have indicated that bile acids can cause placenta vasoconstriction [22] and affect the placental transport and hormone production. In addition bile acids have been shown to increase myometrial sensitivity to oxytocin in humans and cause colonic contraction in animal fetuses increasing the passage of meconium [18]. These findings likely explain the roughly 3 fold increase in meconium stained liquor and pre-term labor observed among the mothers with ICP.…”

Section: Discussionsupporting

confidence: 52%

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Presence of Obstetrics Cholestasis in Mothers Presenting with Pruritus in Pregnancy: In a Low Resource South Asian Setting

Dodampahala¹,

Pieris²,

Chandrasena³

et al. 2016

ARSci

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Obstetric cholestasis (also referred to as intrahepatic cholestasis of pregnancy-ICP) is a pruritic form of reversible cholestasis that is associated with significant fetal risks. There is a paucity of research regarding pregnancy outcomes of the mothers with obstetric cholestasis in the South Asian setting. Hence, the objective of this study was to determine the prevalence of obstetric cholestasis among mothers presenting with pruritus during pregnancy and to describe the characteristics and outcomes for those diagnosed with ICP in comparison with those with pruritus in the absence of ICP. Methods: All mothers presenting with pruritus to De Soyza Maternity hospital in Colombo Sri Lanka, between 1st January 2011 to 1st January 2014, were recruited for the study. A standard set of biochemical tests were used for diagnosis of ICP. An interviewer administered questionnaire and patient records were used for data collection. Presentation, characteristics and pregnancy outcomes were assessed and compared for mothers with ICP against those with pruri-

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Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 52%

Presence of Obstetrics Cholestasis in Mothers Presenting with Pruritus in Pregnancy: In a Low Resource South Asian Setting

Dodampahala¹,

Pieris²,

Chandrasena³

et al. 2016

ARSci

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“…The mechanisms of preterm delivery in ICP is not clear, but studies show an increased response of myometrial strips from healthy women to oxytocin and an increased oxytocin-receptor expression after being incubated with cholic acid [8]. 14.81% deliveries in ICP group resulted in preterm deliveries as compared to 6.33% in control group.…”

Section: Discussionmentioning

confidence: 98%

“…Studies show an alteration to electrical signaling in myocytes following exposure to bile acids [8].…”

Section: Discussionmentioning

confidence: 99%

Cholestasis of Pregnancy : A Prospective Study

Singh

Sidhu²

2008

Medical Journal Armed Forces India

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Background: Intrahepatic cholestasis of pregnancy (ICP) typically occurs during the last trimester of gestation. The most accurate marker for diagnosis and follow-up of ICP is increased total bile acid levels (above 11.0 micro mol/L) [1]. ICP is a benign disease with no consequences to the mother but it is associated with an increased rate of fetal morbidity and mortality. Method: A prospective study was carried out in 1500 deliveries which included 27 cases of ICP. The mode of delivery, complications and fetal outcome of intrahepatic cholestasis group were compared with rest of the deliveries. Cases having pruritic lesions of skin, viral hepatitis, gall stones, autoimmune liver diseases were excluded. Random selection of 300 pregnancies in the control group was done and their liver function tests were carried out for comparison. All the patients with cholestasis of pregnancy were treated with ursodeoxycholic acid. Result: The levels of the aminotransferases and alkaline phosphatase levels rose significantly (p < 0.05) in the study group. Cholestatic group did not have any significant difference in mode of delivery or fetal outcome from the control group. The patients in the study group were treated with ursodeoxycholic acid with significant relief in symptoms (p < 0.01), while improvement in serum bilirubin levels, alkaline phosphatase levels and aminotransferases levels were not statistically significant. Conclusion: In absence of serum bile acids levels, alkaline phosphatase and aminotransferases levels may help in diagnosis and management of cholestasis of pregnancy. Ursodeoxycholic acid treatment is effective in reducing the pruritus. MJAFI 2008; 64 : 343-345

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“…Second, a vasoconstrictive effect of BA on placental chorionic veins has been observed, possibly explaining the occurrence of fetal distress, asphyxia and death [7]. Finally, several studies have shown BA to increase the sensitivity and expression of oxytocin receptors in the human myometrium, possibly clarifying the mechanism behind spontaneous preterm labor in pregnancies that are complicated by ICP [8].…”

mentioning

confidence: 99%

Intrahepatic cholestasis of pregnancy and fetal outcomes. Mini review

Külhan¹,

Kulhan²,

Naykı³

et al. 2017

Arch Med Sci Civil Dis

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A b s t r a c tIntrahepatic cholestasis of pregnancy (ICP), a pregnancy-related liver disease, leads to complications for both mother and fetus. It is the most common liver disease in pregnant women. The incidence of ICP has varied widely in different reports (ranging from 0.1 to 15.6%), for reasons that are incompletely understood. Hormonal, immunologic, genetic, environmental and alimentary factors have been implicated in the etiology of ICP. Although a clear correlation between elevated levels of maternal serum bile acids and deficient fetal outcome has been established in clinical practice, the underlying mechanisms remain elusive. Here we present a mini literature review about intrahepatic cholestasis of pregnancy and fetal outcomes.

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Bile acids increase response and expression of human myometrial oxytocin receptor

Cited by 125 publications

References 17 publications

Presence of Obstetrics Cholestasis in Mothers Presenting with Pruritus in Pregnancy: In a Low Resource South Asian Setting

Presence of Obstetrics Cholestasis in Mothers Presenting with Pruritus in Pregnancy: In a Low Resource South Asian Setting

Cholestasis of Pregnancy : A Prospective Study

Intrahepatic cholestasis of pregnancy and fetal outcomes. Mini review

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