Bile and detergent interaction with the radioassay for vitamin B12 binders using protein and dextran-covered charcoal

Andersen, Knut-Jan; Lippe, G von der; Schjønsby, H

doi:10.1016/0003-2697(76)90230-x

Cited by 12 publications

(1 citation statement)

References 18 publications

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“…The combination of bile acids to free intrinsic factors in the upper intestine might prevent the inhibition that would otherwise occur. Alternatively, bile acids may cause dissociation of the amatoxin-intrinsic factor complex at the given receptor site, thus enhancing amatoxin absorption [ 24 , 25 , 26 ]. However, there is little evidence to support the above hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Effect of Biliary Drainage on the Toxicity and Toxicokinetics of Amanita exitialis in Beagles

Sun

Zhang

Niu

et al. 2018

Toxins

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Amatoxin poisoning induces delayed-onset acute liver failure, which are responsible for more than 90% of deaths in mushroom poisoning. It has been postulated from animal and human studies that biliary drainage interrupting enterohepatic amatoxin circulation may affect amatoxin poisoning. Dogs were randomly divided into four groups of six animals each. In 20 mg/kg and 60 mg/kg with biliary drainage groups, after accepting bile drainage operation, beagles were fed Amanita exitialis powder (20 or 60 mg/kg) in starch capsules. In control and bile drainage groups, the beagle dogs were fed with empty capsules. They were assessed for toxicity signs, biochemical and pathological changes, and peptide toxins in plasma, urine and bile. The data were directly compared with those from our published studies on Amanita exitialis-exposed beagles without biliary drainage. Amatoxins were rapidly absorbed and eliminated from plasma after Amanita exitialis ingestion. Amatoxins in 0–1-day urine accounted for more than 90% of the total urine excretion, and amatoxins in bile accounted for less than 20% of the total urine and bile excretion. The dogs with biliary drainage showed less severe toxicity signs and biochemical and pathological changes and much lower internal exposure than dogs without biliary drainage. Biliary drainage caused a more than 70% reduction in intestinal amatoxin absorption and could reduce amatoxin absorption from the gastrointestinal tract.

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Section: Discussionmentioning

confidence: 99%