Bile duct strictures associated with hepatic arterial infusion chemotherapy

Abstract

We report 6 cases of bile duct strictures in patients receiving intraarterial floxuridine chemotherapy for metastatic colon carcinoma. The computed tomographic and cholangiographic features of these cases mimic those seen with primary sclerosing cholangitis. The postulated mechanism for development of biliary strictures is direct toxicity and/or occlusion of the peribiliary vascular plexus with resultant biliary fibrosis.

Treatment of malignant digestive tract obstruction by combined intraluminal stent installation and intra-arterial drug infusion

“…Drug infusion via supplying artery and embolization therapy have been used in clinical practice as an effective way of suppressing the growth of malignant tumors [32][33][34][35][36][37][38][39][40][41][42][43] But up to now there have been few reports of the combined use of the two in the treatment of malignant stenotic lesions [44,45] . We have used the combined therapy in cases of malignant stenosis of digestive tract and have obtained good results in relieving symptoms, improving quality of life and prolongation of survival time.…”

Biliary Strictures: Etiologies and Medical Management

“…13,14 Iatrogenic strictures can also develop as a consequence of prior radiation therapy or can be drug induced, commonly secondary to chemotherapy. 15 Chemotherapy-associated sclerosing cholangitis results from hepatic artery inflammation and typically involves the intrahepatic bile ducts. Culprit chemotherapeutic agents include 5-fluorouracil and bevacizumab.…”

Diseases of the Gallbladder and Bile Ducts

“…The findings by computed tomography and cholangiography may simulate the stenosing and obstructive characteristics of primary sclerosing cholangitis (Fig. 21) [90].…”