Bile metabolites of polycyclic aromatic hydrocarbons (PAHs) in three species of fish from Morocco

Baali, Ayoub; Kammann, Ulrike; Hanel, Reinhold; Qoraychy, Ikram El; Yahyaoui, Ahmed

doi:10.1186/s12302-016-0093-6

Cited by 29 publications

(6 citation statements)

References 29 publications

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“…The bile concentration of 3-OH-BaP has been used as an indicator of BaP exposure and biotransformation in many fish species including polar cod (Baake et al, 2016;Baali et al, 2016;Kammann et al, 2017;Song et al, 2019). Indeed, previous studies led on polar cod exposed to either PAHs or crude oil have shown a very high correlation between bile metabolites of PAHs and both cyp1a mRNA expression and EROD activity (Bakke et al, 2016, Bender et al, 2016, Vieweg et al, 2018, Song et al, 2019.…”

Section: Discussionmentioning

confidence: 99%

Susceptibility of polar cod (Boreogadus saida) to a model carcinogen

Lerebours

Мурзина

Shang

et al. 2021

Marine Environmental Research

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Studies that aim to characterise the susceptibility of the ecologically relevant and non-model fish polar cod (Boreogadus saida) to model carcinogens are required. Polar cod were exposed under laboratory conditions for six months to control, 0.03 µg BaP/ g fish/ week and 0.3 µg BaP/ g fish/ week dietary benzo(a)pyrene (BaP), a reference carcinogen. The concentrations of the 3-OH-BaP bile metabolite and transcriptional responses of genes involved in DNA adduct recognition (xpc), helicase activity (xpd), DNA repair (xpf, rad51) and tumour suppression (tp53) were assessed after 0, 1, 3 and 6 months of exposure, alongside body condition indexes (gonadosomatic index, hepatosomatic index and condition factor).Micronuclei and nuclear abnormalities in blood and spleen, and liver histopathological endpoints were assessed at the end of the experiment.Fish grew steadily over the whole experiment and no mortality was recorded. The concentrations of 3-OH-BaP increased significantly after 1 month of exposure to the highest BaP concentration and after 6 months of exposure to all BaP concentrations showing the biotransformation of the mother compound. Nevertheless, no significant induction of gene transcripts involved in DNA damage repair or tumour suppression were observed at the selected sampling times. These results together with the absence of chromosomal damage in blood and spleen cells, the subtle increase in nuclear abnormalities observed in spleen cells and the low occurrence of foci of cellular alteration suggested that the exposure was below the threshold of observable effects. Taken together, the results showed that polar cod was not susceptible to carcinogenesis using the BaP exposure regime employed herein.

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Section: Discussionmentioning

confidence: 99%

Susceptibility of polar cod (Boreogadus saida) to a model carcinogen

Lerebours

Мурзина

Shang

et al. 2021

Marine Environmental Research

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“…Characteristic nature of PAHs plays an important role in their dispersal, deposition and impact within the environment part on the whole ecosystem [10]. Various sources have been reported for their production [11][12][13]. Furthermore, their synthesis can also be made possible by discharge of electricity in decorative items like paints, glue and other protection products [14].…”

Section: Introductionmentioning

confidence: 99%

Quantification of Selected Polycyclic Aromatic Hydrocarbons (PAHs) in Soil, Water and Blood by an Optimized and Validated HPLC –UV–DAD Method

Khan¹,

Imran²,

Hashmi³

et al. 2022

Pol. J. Environ. Stud.

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Polycyclic aromatic hydrocarbons (PAHs) are produced as primary environmental pollutants as a result of incomplete combustion of fuels. They harbor mutagenic and carcinogenic properties. Their continuous monitoring is considered a requisite for keeping them into admissible limits. The current study was designed to quantify the levels of PAHs in soil, water and blood samples. One hundred and fifty samples each of soil, water, human and animal blood were collected from highly exposed areas including industrial, highways and incinerators linked areas around Lahore city, Punjab, Pakistan. Amounts of six selected PAHs (Phenanthrene, Biphenyl, Biphenthrene, Naphthalene, Anthracene and P-Ansidine) were quantified by reverse phase-high performance liquid chromatography (RP-HPLC) equipped with UV-VIS photodiodes array detector (PDA) at 247 nm. An isocratic method was optimized and validated for use with soil, water and plasma samples. To obtain the reliable results the HPLC method was validated following the ICH/FDA guidelines. It was found that PAHs exist in large quantity in highly exposed areas particularly the soil samples were extremely contaminated with PAHs. The highest average concentration of Naphthalene (260.85±165.64 µg/kg) was detected in samples from industrial areas. Conversely, the lowest average amount of Biphenanthrene (10.31±3.46 µg/kg) was found in samples from highways. Human and animal plasma samples were also found to carry PAHs in comparatively lower levels than soil and water.

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“…[30,35,39]) as well as mussels and other molluscs [3,6,28,29]. In addition, different Moroccan fish species were analyzed for various contaminants [1,4,8,43]. As a popular food fish in coastal areas of Morocco, European conger from different origins have been previously a target for heavy metal analyses [8,14,42].…”

Section: Introductionmentioning

confidence: 99%

Heavy metal contamination in European conger (Conger conger, Linnaeus 1758) along the coastline of Morocco

et al. 2022

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Background In Morocco, fish is an important protein source especially, even not exclusively, for coastal communities and marketed fresh all along the coastline. One of the main targets of coastal artisanal fisheries is the European conger (Conger conger, Linnaeus 1758), a widely distributed benthic predatory species of a maximum weight of up to 50 kg. However, information on heavy metal contamination of conger is scarce. Therefore, concentrations of mercury, lead and cadmium were analysed in 108 European conger specimens from nine locations along the along the Atlantic and Mediterranean coasts of Morocco to describe the spatial distribution of heavy metal contamination. Results The average heavy metal concentration in all conger samples under investigation was 246.90 ± 216.83 µg mercury/kg wet mass, 74.14 ± 87.02 µg lead/kg wet mass and 255.12 ± 287.15 µg cadmium/kg wet mass respectively. Mercury and cadmium showed a clear site-specific bioaccumulation in European conger but lead does not. Hence, the effect of fish length bias on contamination was corrected through a generalized linear model (GLM) prior to any spatial comparison. Conclusions Different regional hotspots for the three analysed metals are identified and local sources are discussed. Mercury levels in big specimens of European conger exceeded the European threshold level for human consumption at some of the locations under investigation.

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Bile metabolites of polycyclic aromatic hydrocarbons (PAHs) in three species of fish from Morocco

Cited by 29 publications

References 29 publications

Susceptibility of polar cod (Boreogadus saida) to a model carcinogen

Susceptibility of polar cod (Boreogadus saida) to a model carcinogen

Quantification of Selected Polycyclic Aromatic Hydrocarbons (PAHs) in Soil, Water and Blood by an Optimized and Validated HPLC –UV–DAD Method

Heavy metal contamination in European conger (Conger conger, Linnaeus 1758) along the coastline of Morocco

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