Biliary bile acids and cholesterol in developing sheep

Taurocholate pool size and distribution in the fetal rat.

“…The gallbladder and intestinal bile salts of fetal and neonatal rabbits have been identified and quantified (11). Bile salt synthesis, 1042 secretion, and turnover have been measured in the near-term fetuses of large laboratory animals (12)(13)(14)(15)(16). Pool size and synthesis rates have been determined for newborn infants using stable isotope techniques (17,18) or by measuring fecal bile salt excretion (10,19).…”

Fetal bile salt metabolism

“…Until recently, however, little was known about bile salt metabolism during early mammalian development, except for information derived from limited observations on the bile salts in the gallbladder bile and intestine of the near-term fetus and early neonate (5)(6)(7)(8)(9). A recent study in fetal dogs in which tracer doses of cholate-"C were used indicated that the fetal liver has a remarkably mature and ef-…”

Conjugated Bile Acids and Intestinal Flora During the Preruminant Stage in Goat. Influence of a Lamb Milk Replacer

“…In the preruminant goat, the pattern was similar to that of carnivores and sheep, in which bile acids are conjugated with taurine (Peric-Golia & Socic, 1968) an aminoacid abundant in goat's milk and according to Hickman et al, (1992), taurine status affects taurocholic acid kinetics and bile acids composition.…”

“…As noted by Peric-Golia and Socic (1968), bile acids conjugation is affected in part by the type of feeding. Herbivores tend to conjugate with glycine whereas tauroconjugation predominates in carnivores (Haslewood, 1967).…”

“…As the placenta allows the passage of bile acids from the mother to the fetus (Setchel et al, 1988) the greater proportion of glycoconjugated bile acids found at birth probably reflected the presence of maternal bile acids. According to Peric-Golia and Socic (1968), the concentration of bile acids conjugated with glycine is higher in adult sheep than in lambs suggesting that placental transferral during pregnancy is possible.…”