Bilirubin as an important physiological modulator of oxidative stress and chronic inflammation in metabolic syndrome and diabetes: a new aspect on old molecule

Inoguchi, Toyoshi; Sonoda, Noriyuki; Maeda, Yasutaka

doi:10.1007/s13340-016-0288-5

Cited by 32 publications

(27 citation statements)

References 19 publications

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“…Bilirubin is an endogenous antioxidant which promotes lipid peroxidation prevention [41]. Inoguchiet et al [42] reported that bilirubin plays a protective role against chronic inflammation. Together, it seems that greater basal concentrations of cholesterol and bilirubin are related to higher sensitivity to inflammation and susceptibility to diseases in the high line.…”

Section: Biochemical Parametersmentioning

confidence: 99%

Inflammatory Correlated Response in Two Lines of Rabbit Selected Divergently for Litter Size Environmental Variability

Beloumi

Blasco

Muelas

et al. 2020

Animals

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A divergent selection experiment for environmental variance of litter size variance was carried out in rabbits over thirteen generations. The aim of this study was to evaluate the inflammatory response in the two lines of the experiment, in order to analyse the effect of selection on susceptibility to diseases after challenging to stressful situations, such as 24 h after the first delivery. A total of 78 females were used in this study, 39 from each line. The line selected for litter size heterogeneity (the high line) showed lower white blood leukocyte count (WBC; −0.87 × 103/µL), lower percentage of basophils (−0.11%), higher concentration of TNF-α (+13.8 pg/mL), and greater concentration of CRP (+38.1 µg/mL) than the line selected for litter size homogeneity (the low line). The high line had also higher concentrations of bilirubin, cholesterol, gamma-glutamyl transferase (GGT) and alkaline phosphatase (ALP) compared to the low line (difference between lines were +0.08 µmol/L, +0.14 µmol/L, +0.35 U/L and +2.4 U/L, respectively). The high line showed higher inflammatory response than the low line, in accordance with a larger susceptibility to infectious disorders. In conclusion, the line selected to increase litter size environmental variability seems to have poor capacity coping with environmental stressors. Therefore, selection for litter size environmental variability can be a useful way to improve animal welfare.

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Section: Biochemical Parametersmentioning

confidence: 99%

Inflammatory Correlated Response in Two Lines of Rabbit Selected Divergently for Litter Size Environmental Variability

Beloumi

Blasco

Muelas

et al. 2020

Animals

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“…T2DM is characterized by insulin resistance, an in ammatory phenotype, oxidative stress and increased advanced glycation end-products (AGEs), which may lead to cell death and further losses in skeletal muscle mass, strength, and function, nally facilitating the occurrence of sarcopenia [10]. Bilirubin is one of the most active endogenous antioxidant molecules and has been proved bene cial to the prevention and treatment of T2DM [11][12][13][14]21]. However, the role of bilirubin in the pathophysiology of sarcopenia in patients with T2DM has not been explored.…”

Section: Discussionmentioning

confidence: 99%

“…It is well known that elevated oxidative stress and in ammation play important roles in the pathogenesis of diabetic sarcopenia [10]. Bilirubin, the end product of heme metabolism, has been recently con rmed to play a protective role in metabolic syndrome and diabetes through antagonizing oxidative stress and chronic in ammation [11][12][13][14]. Till now, few studies explored the relationship between bilirubin levels and sarcopenia and no de nite conclusion had been reached [15,16].…”

Section: Introductionmentioning

confidence: 99%

Association of Serum Bilirubin Levels With Sarcopenia in Patients With Type 2 Diabetes: a Cross-Sectional Study in China

Wang

Chen

Liu

et al. 2020

Preprint

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Background: The prevalence of sarcopenia increased in type 2 diabetes mellitus (T2DM). Elevated oxidative stress and inflammation played important roles in the pathogenesis of diabetic sarcopenia. Bilirubin had been confirmed to possess potential anti-oxidative activity. This study aimed to explore the relationship between bilirubin and sarcopenia in patients with T2DM. Methods: A total of 251 patients (124 men and 127 postmenopausal women) with T2DM aged ≥ 50 years were recruited. Levels of serum total bilirubin (TBIL), direct bilirubin (DBIL) and indirect bilirubin (IBIL) were measured. Muscle mass was measured by dual-energy X-ray absorptiometry (DXA). The relationships between serum bilirubin levels and appendicular skeletal muscle mass index (SMI) were assessed using a Pearson correlation analysis and multiple linear regression analysis in men and women, respectively. Multiple logistic regression analysis was used to evaluate the association of the highest quartile of serum bilirubin levels with sarcopenia.Results: TBIL (r =0.211, p = 0.019) and IBIL (r =0.249, p = 0.005) were positively associated with SMI in men, but not in women. After multiple adjustment in multiple linear regression analysis, TBIL (p = 0.023) and IBIL (p = 0.012) were also significantly associated with SMI in men. In multiple logistic regression analysis, the highest quartile of IBIL showed a decreased OR for sarcopenia (OR=0.243, P = 0.009) in men. Conclusions: Both of TBIL and IBIL were positively associated with muscle mass in men with T2DM. IBIL might have a stronger protective effect on the occurrence of sarcopenia in men with T2DM.

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“…Bilirubin has recently gained renewed attention as a relevant modulator of oxidative stress and chronic inflammation processes (Inoguchi, Sonoda, & Maeda, 2016;Thakkar, Edelenbos, & Doré, 2019). Rather than being just a toxic waste product of catabolism, accumulating evidence has shown that bilirubin has protective effects upon various oxidative stress-associated conditions and diseases (Levitt & Levitt, 2014;Takeda, Mu, Tai, Kitajima, & Taketani, 2015).…”

Section: Introductionmentioning

confidence: 99%

Human elastin‐like polypeptides as a versatile platform for exploitation of ultrasensitive bilirubin detection by UnaG

Bandiera

Corich

Tommasi

et al. 2019

Biotech & Bioengineering

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A new, bifunctional recombinant protein was expressed as the fusion product of human elastin‐like polypeptide (HELP) and the bilirubin‐binding protein UnaG. The engineered product displays both the HELP‐specific property of forming a functional hydrogel matrix and the UnaG‐specific capacity of emitting green fluorescence upon ligand binding. The new fusion protein has been proven to be effective at detecting bilirubin in complex environments with high background noise. A cell culture model of the stress response, consisting of bilirubin released in the cell culture medium, was set up to assess the bilirubin‐sensing properties of the functional matrix obtained by cross‐linking the HELP moiety. Our engineered protein allowed us to monitor cell induction by the release of bilirubin in the culture medium on a nanomolar scale. This study shows that elastin‐like protein fusion represents a versatile platform for the development of novel and commercially viable analytical and biosensing devices.

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Bilirubin as an important physiological modulator of oxidative stress and chronic inflammation in metabolic syndrome and diabetes: a new aspect on old molecule

Cited by 32 publications

References 19 publications

Inflammatory Correlated Response in Two Lines of Rabbit Selected Divergently for Litter Size Environmental Variability

Inflammatory Correlated Response in Two Lines of Rabbit Selected Divergently for Litter Size Environmental Variability

Association of Serum Bilirubin Levels With Sarcopenia in Patients With Type 2 Diabetes: a Cross-Sectional Study in China

Human elastin‐like polypeptides as a versatile platform for exploitation of ultrasensitive bilirubin detection by UnaG

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