Binary catalytic therapy: A new approach to treatment of malignant tumors. Results of pre-clinical and clinical studies

Accurate Prediction of Mössbauer Hyperfine Parameters in Bis-Axially Coordinated Iron(II) Phthalocyanines Using Density Functional Theory Calculations: A Story of a Single Orbital Revealed by Natural Bond Orbital Analysis

“…HOMO energy was observed for the alkylamine series, while clear HOMO stabilization was observed going from pyridine (15) to pyrazine (16) to tetrazine (18). The HOMO in the carbon monoxide-coordinated complexes (27)(28)(29)(30)(31)(32) is more stable than in complexes with nitrogen donors, with the most stable HOMO being observed for the PcFe(CO) 2 complex. The main difference in the BPW91 and MN12L calculations can be seen in the nature of the HOMO.…”

“…10−16 Monomeric and dimeric iron phthalocyanine complexes can facilitate versatile chemistry, including the oxidization of a large array of organic substrates, and participate in electrocatalytic oxygen reduction. 17 −30 In addition, iron phthalocyanines have been proposed as active components in catalytic antibacterial and cancer therapy, 31,32 electrochemical detection of organic substrates, 33−36 and optical sensors for the detection of carbon monoxide or nitrogen oxides. 37−41 The most diverse group of iron phthalocyanine derivatives are bis-axially coordinated iron(II) compounds, which have the general formulas PcFeL 2 , PcFeL′L″, or [PcFeX 2 ] 2− (where L, L′, and L″ are neutral ligands and X − are anionic ligands).…”

Application of Lever’s EL Parameter Scale toward Fe(II)/Fe(III) versus Pc(2-)/Pc(1-) Oxidation Process Crossover Point in Axially Coordinated Iron(II) Phthalocyanine Complexes

“…In light of Lever’s work and the considerable academic and industrial interest surrounding iron phthalocyanine (PcFe II ) derivatives, − this work focuses on expanding the already rich chemistry of these complexes. Indeed, iron phthalocyanine complexes have been studied as catalysts for C–H bond activation, − electrocatalysts for the oxygen reduction reaction, − active components for catalytic cancer therapy, , platforms for optical detection of small molecules, − and composite materials for electrochemical detection of biologically relevant species. − The axial coordination of nitrogen bases, − phosphines and phosphites, − nitroso compounds, sulfoxides and sulfides, − carbon monoxide, − and isonitriles − to iron­(II) phthalocyanine was studied by UV–visible, NMR, and Mössbauer spectroscopies as well as by crystallography. Based on early electrochemical, spectroelectrochemical, chemical, , and photochemical oxidation data, it was always assumed that the highest occupied m...…”

Synthesis of 4,5-Dicyanophthalic Acid and Its Functional Derivatives

“…IR (KBr) ν cm -1 : 3118, 3056, 2244, 1864, 1756. 4,5-Dicyano-N-nonylphthalimide (18). The mixture of anhydride 10 (0.10 g, 0.51 mmol), 1-nonylamine (0.11 ml, 0.61 mmol) and acetic acid (1 ml) with one drop of pyridine was refluxed …”

“…[15,16] OCPcCo sodium salt under the trade name Theraphthal ® is currently under clinical trials for the catalytic cancer therapy. [1,17,18] Sodium salts of OCPcCo and OCPcZn are also studied as sensitizers for sonodynamic cancer therapy. [19,20] Sodium salts of OCPcM (M = Al, Co, Zn, Fe) are precursors for the synthesis of covalent exocyclic conjugates with Pt II .…”