Binary mixed micelles of polysorbates (Tween 20 and Tween 60) and bile salts (Na-hyodeoxycholate and Na-cholate): Regular solution theory and change of pKa values of micellar bile acid – a novel approach to estimate of the stability of the mixed micelles

Niosomes Consisting of Tween-60 and Cholesterol Improve the Chemical Stability and Antioxidant Activity of (−)-Epigallocatechin Gallate under Intestinal Tract Conditions

“…There are reports that surfactants (such as polysorbate) bind proteins and enzymes 44 and their complexes may destabilize the niosomes. Bile acid micelles bind cholesterol, 45 and Tween also interacts with bile salts 46 through its hydrophobic tail. These observations suggest that the niosomal membrane consisting of Tween 60 and cholesterol may be disturbed by the bile salts and pancreatin in SIF.…”

Ascorbyl palmitate/d-α-tocopheryl polyethylene glycol 1000 succinate monoester mixed micelles for prolonged circulation and targeted delivery of compound K for antilung cancer therapy in vitro and in vivo

“…8,9 In addition, the application of binary mixture of surfactants, especially for obtaining micellar solutions, by changing the molar fraction of the surfactants in their binary mixture, can lead to an increased solubility capacity of the micellar system. 10,11 d-α-Tocopheryl polyethylene glycol 1000 succinate monoester (TPGS) is a PEGylated vitamin E that has great advantages in enhancing the solubility and inhibiting P-gp efflux. 12,13 In addition, after micelle formation, it can escape recognition and elimination in vivo and has a prolonged circulation.…”

An investigation of Pluronic P123–sodium cholate mixed system: micellization, gelation and encapsulation behavior

“…Furthermore, the effect of bile salts on the aggregation characteristics of Pluronics at both low and high concentration regimes i.e., micellization and gelation is still unexplored. It has been reported [46][47][48] For CMT determination by densitometric measurements, total concentration of binary mixtures was xed at 1 mM and mole fraction of P123 : NaC varied as 1 : 9, 3 : 7, 5 : 5, 7 : 3 and 9 : 1.…”