Binational Dengue Outbreak Along the United States–Mexico Border — Yuma County, Arizona, and Sonora, Mexico, 2014

Jones, Jefferson M.; Lopez, Benito; Adams, Laura; Gálvez, Francisco Javier Navarro; Núñez, Alfredo Sánchez; Santillán, Nubia Astrid Hernández; Plante, Lydia; Hemme, Ryan R.; Casal, Mariana; Hunsperger, Elizabeth; Muñoz‐Jordán, Jorge L.; Acevedo, Verónica; Ernst, Kacey C.; Hayden, Mary H.; Waterman, Steve; Gómez, Diana Paola Buitrago; Sharp, Tyler M.; Komatsu, Kenneth; Team, Dengue Investigative; Program, Cdc Epidemiology Elective

doi:10.15585/mmwr.mm6519a3

Cited by 21 publications

(17 citation statements)

References 6 publications

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“…Other studies performed on the Mexico-U.S. border also report dengue in slightly more females than males, although it is important to note that often slightly more females than males also present with suspected dengue. 19,20,38,39 In this regard, 57% of patients in our entire 27,40,41 Most of the patients with suspected dengue did not have laboratory-confirmed DENV infections, as observed in other dengue studies performed in Mexico. 27,40,42 Taken together, the epidemiological characteristics of dengue in Reynosa in 2014-2016 are similar to those reported in many other dengue investigations.…”

Section: Discussionsupporting

confidence: 71%

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Surveillance for Flaviviruses Near the Mexico–U.S. Border: Co-circulation of Dengue Virus Serotypes 1, 2, and 3 and West Nile Virus in Tamaulipas, Northern Mexico, 2014–2016

Laredo-Tiscareño

Garza-Hernández

Salazar

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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A clinical, serological, and molecular investigation was performed to determine the presence of dengue virus (DENV) and other flaviviruses among residents of the city of Reynosa, Tamaulipas, on the Mexico-U.S. border in 2014-2016. The sample population consisted of 2,355 patients with suspected dengue, in addition to 346 asymptomatic individuals recruited during a household-based epidemiological investigation designed to identify flavivirus seroconversions. Sera were collected from patients with suspected dengue in the acute phase of illness and from asymptomatic individuals at enrollment and every 5-7 months for 19 months. Sera from suspected dengue patients were tested for DENV antigen by enzyme-linked immunosorbent assay (ELISA), and select antigen-positive sera were further tested using a serotype-specific, quantitative reverse transcription-polymerase chain reaction. Sera from the household cohort were tested for flavivirus-reactive antibodies by immunoglobulin (Ig) M and IgG ELISAs using DENV antigen. A total of 418 (17.7%) patients with suspected dengue had laboratory-confirmed DENV infections, including 82 patients who were positive for DENV RNA. The most frequently detected serotype was DENV-1 (61 patients), followed by DENV-2 (16 patients) and DENV-3 (five patients). A total of 217 (62.7%) asymptomatic individuals had flavivirus-reactive antibodies at enrollment, and nine flavivirus-naïve individuals seroconverted. Sera from a subset of dengue patients and household participants, including all those who seroconverted, were further tested by plaque reduction neutralization test, resulting in the detection of antibodies to DENV-1, DENV-2, and West Nile virus. In summary, we provide evidence for the co-circulation of multiple flaviviruses in Reynosa, Tamaulipas, on the Mexico-U.S. border.

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Section: Discussionsupporting

confidence: 71%

“…Other studies performed in northern Mexico report similar findings. 17,27,38,39 Most confirmed cases of dengue identified in southern Texas in 2013 also occurred during these months. 20 The dengue season coincides with peak mosquito abundance which is dependent on climatic conditions favorable for mosquito breeding.…”

Section: Discussionmentioning

confidence: 99%

Surveillance for Flaviviruses Near the Mexico–U.S. Border: Co-circulation of Dengue Virus Serotypes 1, 2, and 3 and West Nile Virus in Tamaulipas, Northern Mexico, 2014–2016

Laredo-Tiscareño

Garza-Hernández

Salazar

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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“…The necessity for and dearth of effective and approved treatments for acute viral infections was on full display after the Ebola outbreak in West Africa in 2014. The United States has also seen other mosquito-borne viruses (West Nile, dengue, and Zika viruses) emerge or re-emerge over the last twenty years, and effective antivirals against these viruses are direly needed as a matter of public health (Butterworth et al, 2016; Jones et al, 2016; Millman et al, 2016; Murray et al, 2010; Weaver et al, 2016). RNA viruses are inherently error prone, therefore they often quickly mutate in the presence of drugs that target viral proteins and viral enzymes (De Clercq, 2013; Flint SJR, 2015b).…”

Section: Discussionmentioning

confidence: 99%

Rapamycin modulation of p70 S6 kinase signaling inhibits Rift Valley fever virus pathogenesis

et al. 2017

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Despite over 60 years of research on antiviral drugs, very few are FDA approved to treat acute viral infections. Rift Valley fever virus (RVFV), an arthropod borne virus that causes hemorrhagic fever in severe cases, currently lacks effective treatments. Existing as obligate intracellular parasites, viruses have evolved to manipulate host cell signaling pathways to meet their replication needs. Specifically, translation modulation is often necessary for viruses to establish infection in their host. Here we demonstrated phosphorylation of p70 S6 kinase, S6 ribosomal protein, and eIF4G following RVFV infection in vitro through western blot analysis and in a mouse model of infection through reverse phase protein microarrays (RPPA). Inhibition of p70 S6 kinase through rapamycin treatment reduced viral titers in vitro and increased survival and mitigated clinical disease in RVFV challenged mice. Additionally, the phosphorylation of p70 S6 kinase was decreased following rapamycin treatment in vivo. Collectively these data demonstrate modulating p70 S6 kinase can be an effective antiviral strategy.

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“…Mobility among populations, promoted by tourism, migration and work-seekers, increases the risk of introducing diseases and increases the difficulty of surveillance [60,61]. This transboundary flow is an important vehicle for the spread of different vectors and the serotypes of dengue, thus increasing the potential for epidemics [62].…”

Section: Discussionmentioning

confidence: 99%

Malathion insecticide resistance inAedes aegypti: laboratory conditions andin situexperimental approach through adult entomological surveillance

Leandro¹,

Rios²,

Britto³

et al. 2020

Tropical Med Int Health

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objective In Brazil, the most common method of controlling outbreaks of arbovirus is by the use of chemical sprays, which kill the insect vector, Aedes aegypti. The main objective of this study was to evaluate the resistance of Ae. aegypti to the insecticide, malathion, in situ. The location of this study was the municipality of Foz do Iguaçu, in the state of Paraná, Brazil. methods Ultra-low-volume (ULV) fogging equipment was used, by vehicle, to apply the insecticide in situ, and mosquito populations after treatment were compared with those of control areas. The resistance of strains collected from the municipality was compared to the Rockefeller strain under laboratory conditions. results We found 220 adult female specimens and 7423 eggs of Ae. aegypti in the areas subjected to UBV treatment, whereas 245 adult females and 10 557 eggs were found in the control areas. The UBV treatment area showed no significant difference compared to the control area, for all the indices. Mortality of the Rockefeller colony varied more quickly when there were slight variations in malathion concentration than the Foz do Iguaçu population. keywords Arboviruses, entomological surveillance, chemical control, ultra-low volume (ULV), Foz do Iguaçu Sustainable Development Goals (SDGs): SDG 3 (good health and well-being), SDG 15 (life on land), SDG 17 (partnerships for the goals)

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Binational Dengue Outbreak Along the United States–Mexico Border — Yuma County, Arizona, and Sonora, Mexico, 2014

Cited by 21 publications

References 6 publications

Surveillance for Flaviviruses Near the Mexico–U.S. Border: Co-circulation of Dengue Virus Serotypes 1, 2, and 3 and West Nile Virus in Tamaulipas, Northern Mexico, 2014–2016

Surveillance for Flaviviruses Near the Mexico–U.S. Border: Co-circulation of Dengue Virus Serotypes 1, 2, and 3 and West Nile Virus in Tamaulipas, Northern Mexico, 2014–2016

Rapamycin modulation of p70 S6 kinase signaling inhibits Rift Valley fever virus pathogenesis

Malathion insecticide resistance inAedes aegypti: laboratory conditions andin situexperimental approach through adult entomological surveillance

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