Abstract-Binaural sound source localization is an important technique for speech enhancement, video conferencing and human-robot interaction, etc. However, in realistic scenarios, the reverberation and environmental noise would degrade the precision of sound direction estimation. Therefore, reliable sound localization is essential to practical applications. To deal with these disturbances, this paper presents a novel binaural sound source localization approach based on reverberation weighting and generalized parametric mapping. Firstly, the reverberation weighting as a pre-processing stage, is used to separately suppress the early and late reverberation, while preserving interaural cues. Then, two binaural cues, i.e., interaural time and intensity differences, are extracted from the frequencydomain representations of dereverberated binaural signals for the online localization. Their corresponding templates are established using the training data. Furthermore, the generalized parametric mapping is proposed to build a generalized parametric model for describing relationships between azimuth and binaural cues analytically. Finally, a two-step sound localization process is introduced to refine azimuth estimation based on the generalized parametric model and template matching. Experiments in both simulated and real scenarios validate that the proposed method can achieve better localization performance compared to stateof-the-art methods.