Binding and photophysical studies of biocompatible magnetic fluid in biological medium and development of magnetic nanoemulsion: A new candidate for cancer treatment

Primo, Fernando Lucas; Macaroff, P.P.; Lacava, Z.G.M.; Azevedo, Ricardo Bentes; Morais, P.C.; Tedesco, Antônio Cláudio

doi:10.1016/j.jmmm.2006.11.062

Cited by 25 publications

(7 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are reports on: drugs solubilized in nano-emulsions for HIV/AIDS therapy [31]; mechanisms of atherogenesis studied with cholesterol nano-emulsions [32]; cancer therapy investigated by solubilizing the drug in a cholesterol rich nano-emulsion [33]; intestinal absorption of three model drugs solubilized in nano-emulsions [34]; efficacy of a schistosomicidal compound solubilized in nano-emulsions; [35]; and application of anthrax vaccine through W/O nanoemulsions [36]. Special magnetic nano-emulsions are also being studied for medicine applications [37][38][39]. A recent review [40] shows extensively potential multifunctional applications of nanocarriers including nano-emulsions in pharmacy.…”

Section: Direct Application Of Nano-emulsions In Final Productsmentioning

confidence: 99%

Nano-emulsions: New applications and optimization of their preparation

Gutiérrez

González

Maestro

et al. 2008

Current Opinion in Colloid & Interface Science

560

278

View full text Add to dashboard Cite

Section: Direct Application Of Nano-emulsions In Final Productsmentioning

confidence: 99%

Nano-emulsions: New applications and optimization of their preparation

Gutiérrez

González

Maestro

et al. 2008

Current Opinion in Colloid & Interface Science

560

278

View full text Add to dashboard Cite

“…A combined action of local HPT and PDT has been proposed over the last years. − It was observed that for magnetic nanoemulsion containing maghemite nanoparticles and a PS drug, the photophysical properties and triplet quantum yield of PS does not change and was excellent for photodynamic activity and local hyperthermia therapy . Maghemite nanoparticles (γ-Fe 2 O 3 ) also have a particular interest because they might be potential agents for cancer treatment by magnetic hyperthermia therapy .…”

Section: Introductionmentioning

confidence: 99%

“…39−41 It was observed that for magnetic nanoemulsion containing maghemite nanoparticles and a PS drug, the photophysical properties and triplet quantum yield of PS does not change and was excellent for photodynamic activity and local hyperthermia therapy. 42 Maghemite nanoparticles (γ-Fe 2 O 3 ) also have a particular interest because they might be potential agents for cancer treatment by magnetic hyperthermia therapy. 43 In addition, Kim et al 44 demonstrated the photodynamic/hyperthermiacombined therapeutic success of magnetite nanoparticles and photosensitizers conjugated with enhanced efficacy against cancer.…”

Section: Introductionmentioning

confidence: 99%

Use of Spectroscopic Techniques for Evaluating the Coupling of Porphyrins on Biocompatible Nanoparticles. A Potential System for Photodynamics, Theranostics, and Nanodrug Delivery Applications

et al. 2017

View full text Add to dashboard Cite

Modern medicine has been searching for new and more efficient strategies for diagnostics and therapeutics applications. Considering this, porphyrin molecules have received great interest for applications in photodiagnostics and phototherapies, even as magnetic nanoparticles for drug-delivery systems and magnetic-hyperthermia therapy. Aiming to obtain a multifunctional system, which combines diagnostics with therapeutic functions on the same platform, the present study employed UV/vis absorption and fluorescence spectroscopies to evaluate the interaction between meso-tetrakis(p-sulfonatofenyl)porphyrin (TPPS) and maghemite nanoparticles (γ-FeO). These spectroscopic techniques allowed us to describe the dynamics of coupling porphyrins on nanoparticles and estimate the number of 21 porphyrins per nanoparticle. Also, the binding parameters, such as the association constants (K = 8.89 × 10 M) and bimolecular quenching rate constant (k = 2.54 × 10 M s) were obtained. These results suggest a static quenching process where the electrostatic attraction plays an essential role. The work shows that spectroscopic techniques are powerful tools to evaluate the coupling of organic molecules and nanoparticles. Besides, the system studied provides a relevant background for potential applications in bionanotechnology and nanomedicine, such as (1) nanodrug delivery system, (2) photodiagnostics/theranostics, and/or (3) a combined action of photodynamic and hyperthermia therapies, working in a synergetic way.

show abstract

“…Magnetic fluids are so stable that no separation between solid and liquid, or agglomeration of particles is seen in the presence of high magnetic fields. Such solutions having both fluid and magnetic properties have led to numerous industrial applications [10][11][12].…”

Section: Preparation Of Magnetic Fluidmentioning

confidence: 99%

A method to monitor non-ferrous debris in ferrographic analysis

Liu

Yang

2009

Proceedings of the Institution of Mechanical Engineers, Part J:

View full text Add to dashboard Cite

Non-ferrous debris in oil sample provide important information about the wear condition of a wear couple containing non-ferrous metal components. In order to collect wear debris of non-ferrous metal material more effectively and deposit them on a ferrogram in a stable depositing ratio, the method of employing magnetic fluid as a magnetization agent to collect non-ferrous wear debris in ferrography was attempted. Magnetic fluid constituting Fe 3 O 4 magnetic particles was prepared using a precipitation reaction. Tetrachloroethylene was used as a carrier liquid to ensure that magnetic fluid can be easily mixed with lubricant oil sample. Oleic acid was used as a surfactant, which enables magnetic particles to adhere to the surface of non-ferrous wear debris. Then the non-ferrous wear debris was magnetized and deposited on a ferrogram in a stable depositing ratio. Copper debris was chosen as an example of non-ferrous debris to illustrate the magnetization effect of the magnetic fluid. With the help of magnetic fluid, the ferrographic analyst will achieve the operating condition of the machine more accurately.

show abstract

Binding and photophysical studies of biocompatible magnetic fluid in biological medium and development of magnetic nanoemulsion: A new candidate for cancer treatment

Cited by 25 publications

References 10 publications

Nano-emulsions: New applications and optimization of their preparation

Nano-emulsions: New applications and optimization of their preparation

Use of Spectroscopic Techniques for Evaluating the Coupling of Porphyrins on Biocompatible Nanoparticles. A Potential System for Photodynamics, Theranostics, and Nanodrug Delivery Applications

A method to monitor non-ferrous debris in ferrographic analysis

Contact Info

Product

Resources

About