Binding Mechanism and Surface-Enhanced Raman Scattering of the Antimicrobial Sulfathiazole on Gold Nanoparticles

Kha, Tran Ni; Si, Nguyen Thanh; Tran, Van Man; Vo, Khuong Quoc; Nguyen, Minh Tho; Nhat, Pham Vu

doi:10.1021/acsomega.3c01477

Cited by 6 publications

(1 citation statement)

References 51 publications

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“…They display a great potential for diagnosis and personalized treatment either as a substrate for SERS investigations [17][18][19] or by themselves, considering the fact that they can improve antimicrobial activity [20]. A lot of antibiotics such as levofloxacin, tetracycline, benzylpenicillin [11], sulfathiazole [21,22], quinolones [23], ciprofloxacin [24], and many others [17] have been studied through the SERS method. It has also been shown that antibiotic-functionalized gold nanoparticles can detect β-lactamase and be used as a useful tool in combating antimicrobial resistance [25].…”

Section: Introductionmentioning

confidence: 99%

Vibrational Analysis and Concentration Dependent SERS Study of Cefoperazone

Faur,

Tóth,

Magyari

et al. 2024

Chemosensors

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Cefoperazone is a broad-spectrum antibiotic that is extremely efficient in the treatment of respiratory, abdominal, or genital infections. Vibrational spectroscopic techniques, FT-IR, Raman, and SERS, along with DFT calculations, were involved in investigating the normal modes of vibration and adsorption behavior of this antibiotic. Using both the experimental and theoretical data, the bands in the Raman and IR spectra were assigned to the normal vibrational modes. The SERS spectra were successively obtained by using silver and gold colloidal nanoparticles as a substrate. Their analysis revealed that the molecule is chemisorbed on the nanostructured surface through the as-denoted nitrogen ring. Changes observed in the SERS spectra recorded at different cefoperazone concentrations, i.e., modifications in the relative intensity of specific bands suggest the reorientation of adsorbed molecules towards the metal surface.

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