Binding of polycyclic aromatic hydrocarbons (PAHs) to teleost aryl hydrocarbon receptors (AHRs)

Billiard, Sonya M.; Hahn, Mark E.; Franks, Diana G.; Peterson, Richard E.; Bols, Niels C.; Hodson, Peter V.

doi:10.1016/s1096-4959(02)00105-7

Cited by 159 publications

(92 citation statements)

References 47 publications

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“…This complex then binds xenobiotic response elements (XRE) of AHR, thereby inducing transcription of target genes, 24 and polycyclic aromatic hydrocarbons. 25 In addition to its own XRE, the AHRR regulatory region contains a nuclear factor kappa B (NFKB) binding site that works as an inducible enhancer. NFKB and XRE sequences can act cooperatively on the gene transcription machinery, 26 suggesting that inflammation could play a role in AHRR production.…”

Section: Discussionmentioning

confidence: 99%

Offspring DNA methylation of the aryl-hydrocarbon receptor repressor gene is associated with maternal BMI, gestational age, and birth weight

et al. 2015

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(2015) Offspring DNA methylation of the arylhydrocarbon receptor repressor gene is associated with maternal BMI, gestational age, and birth weight, Epigenetics, 10:10, 913-921, DOI: 10.1080/15592294.2015 Prenatal smoke exposure, maternal obesity, aberrant fetal growth, and preterm birth are all risk factors for offspring metabolic syndrome. Cord blood aryl-hydrocarbon receptor repressor (AHRR) DNA methylation is responsive to maternal smoking during pregnancy. AHRR serves not only to inhibit aryl-hydrocarbon receptor (AHR) transcription, which is involved in mediating xenobiotic metabolism, but it is also involved in cell growth and differentiation. Other than maternal smoking, other predictors of offspring AHRR DNA methylation status remain unknown; we sought to identify them among newborns. We enrolled pregnant women in the PROGRESS birth cohort in Mexico City. Using pyrosequencing, we analyzed DNA methylation of 3 CpG sites within the AHRR gene promoter from the umbilical cord blood of 531 infants. We used generalized estimating equations to account for the correlation of DNA methylation between CpG sites. Multivariable models were used to adjust for maternal age, BMI, education, parity, smoke-exposure, infant sex, gestational age, and birth weight-for-gestational age. AHRR DNA methylation was positively associated with maternal BMI (P D 0.0009) and negatively associated with the length of gestation (P < 0.0001) and birth weight-forgestational age (P < 0.0001). AHRR DNA methylation was 2.1% higher in offspring of obese vs. normal weight mothers and 3.1% higher in preterm vs. term infants, representing a third and a half standard deviation differences in methylation, respectively. In conclusion, offspring AHRR DNA methylation was associated with maternal obesity during pregnancy as well as infant gestational age and birth weight-for-gestational age. Further work to discover the health impacts of altered AHRR DNA methylation is warranted.

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Section: Discussionmentioning

confidence: 99%

Offspring DNA methylation of the aryl-hydrocarbon receptor repressor gene is associated with maternal BMI, gestational age, and birth weight

et al. 2015

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“…On the other hand, it was surprising that the deep sediment layers of 20-30 cm, representing a time before large technological transitions in 1992, revealed no increases in amounts of cyp1a transcripts by 20dpfZF (IV), despite doing so in certain model AhR ligands (Billiard et al 2002, Brinkworth et al 2003, Hawliczek et al 2012. We first suggested that the tentative effector, retene, had caused a pronounced induction of cyp1a transcription.…”

Section: Industrial Sediment Ppm: Responses Of Estrogenic Biomarkersmentioning

confidence: 85%

Probing the xeno-oestrogenic impact of sediment cores contaminated by the pulp and paper industry: induction of aromatase cyp19a1b in late larval zebrafish

Sahoo

Oikari

2014

J Soils Sediments

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To assess xenoestrogenicity, the 20 days-post-fertilization zebrafish (20dpfZF) life-stage was experimentally exposed to known model chemicals as well as to environmentally contaminated samples. From a selection of key responsive genes, molecular responses associated with the steroidogenic impact (brain aromatase, cyp19a1b and vitellogenin isoform 1, vtg1) were used to assess the endocrinic modulation by xenoestrogenic samples. This work showed diverse in vivo responses by the 20dpfZF, from pure chemicals (bisphenol A, BPA; 17 -ethinylestradiol, EE2; nonylphenol, NP; octylphenol, OP), and their mixture combinations, and to industrially contaminated sediment samples. Gene expression analysis of cyp19a1b and vtg1 in exposed 20dpfZF showed the estrogenic potencies of chemicals in the order: EE2 > OP > BPA > NP. Transcriptional up-regulation of vtg1 in early juvenile fish exposed to mixtures (BPA + NP + OP), relative to individual concentrations, suggest in minimum the additive in vivo effect of a mixture of very low sublethal doses of single xenoestrogens. Complementary expression of cyp19a1b and vtg1 in 20dpfZF, exposed to artificially-spiked sediment with EE2 established the estrogenresponsiveness of the model. In contrast, the lack of simple estrogenic or antiestrogenic trait of correspondence in biomarker transcription was evident from exposure to two types of industrially contaminated sediments, suggesting common non-linearity of in vivo response by the model. The results also highlight the applicability of 20dpfZF in the assessment of remediation and monitoring of historically polluted sites. This study showed that the 20dpfZF addressed the regulatory requirement of a multi-purpose and cost-effective ecotoxicological model capable of in vivo genomic assessment of endocrineactive substances in aquatic samples.

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“…Mechanisms identified include the triggering of the aryl hydrocarbon receptor (AhR) pathway and downstream molecular cascades. This pathway is, for example, involved in the activation of detoxifying enzymes such as Cyp1 (Billiard et al 2002).…”

mentioning

confidence: 99%

PAHs and fish—exposure monitoring and adverse effects—from molecular to individual level

Cousin

Cachot

2014

Environ Sci Pollut Res

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Binding of polycyclic aromatic hydrocarbons (PAHs) to teleost aryl hydrocarbon receptors (AHRs)

Cited by 159 publications

References 47 publications

Offspring DNA methylation of the aryl-hydrocarbon receptor repressor gene is associated with maternal BMI, gestational age, and birth weight

Offspring DNA methylation of the aryl-hydrocarbon receptor repressor gene is associated with maternal BMI, gestational age, and birth weight

Probing the xeno-oestrogenic impact of sediment cores contaminated by the pulp and paper industry: induction of aromatase cyp19a1b in late larval zebrafish

PAHs and fish—exposure monitoring and adverse effects—from molecular to individual level

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