Bio-based Polymer Isolated from Seeds of Buchanania lanzan Spreng with Potential Use as Pharmaceutical Mucoadhesive Excipient

Singh, Sudarshan; Dodiya, Tanvi; Singh, Sangeeta; Dodiya, Rajesh; Bothara, Sunil B.

doi:10.37285/ijpsn.2020.13.4.9

Cited by 4 publications

(4 citation statements)

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“…Six hours post administration, it was found that the dosage form reached the colonic region. Swelling and distortion in the shape of the tablet were also observed in the colonic region, indicating the drug release in the colon region, and the same observation in similar studies has been observed (Singh et al, 2020(Singh et al, , 2021. The X-ray images in the present study also clearly indicate that the optimized formulation was successfully targeted to the colonic region without any prior drug release.…”

Section: In Vivo Colon Targetingsupporting

confidence: 87%

“…The current animal study was performed as per the procedure mentioned in the experimental protocol cleared by the Institutional Ethics Committee (001/VPC/IAEC/RESEARCH-2018). New Zealand white rabbits (3-3.5 kg) were selected as the animal models to simulate human colonic environment physiology (Singh et al, 2020, Singh et al, 2021. The rabbits were starved overnight with free access to water.…”

Section: In Vivo Targeting Studymentioning

confidence: 99%

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Studies on Jackfruit–Okra Mucilage-Based Curcumin Mucoadhesive Tablet for Colon Targeted Delivery

et al. 2022

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The present work investigates a blend of jack fruit mucilage (JFM) and okra mucilage (OKM) as promising mucoadhesive carriers for colon-specific delivery of a curcumin (CMN)-loaded mucoadhesive tablet (CMT) formulation. Formulation optimization was performed using central composite design (CCD) to further decipher the effect of varying proportions of the mucoadhesive carriers JFM and OKG on response factors such as drug release (% DR) and mucoadhesive strength (MA). The optimized formulation CMT (F14) demonstrated a favorable 54.35% in vitro release of CMN in 12 h with release kinetics resulting from a zero-order anomalous diffusion mechanism and MA of 34.1733 ± 1.26 g. Accelerated stability testing of CMT (F14) confirmed a shelf life of about 4.7 years. In vivo drug targeting studies performed using rabbit models in order to observe transit behavior (colon-specific delivery) of the dosage form were assessed by fluoroscopic images of the GI tract. Taking the results together, the results confirm that the combination of JFM and OKM could be exploited as an ideal mucoadhesive carrier for effective delivery of macromolecules to the colon.

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Section: In Vivo Colon Targetingsupporting

confidence: 87%

Section: In Vivo Targeting Studymentioning

confidence: 99%

Studies on Jackfruit–Okra Mucilage-Based Curcumin Mucoadhesive Tablet for Colon Targeted Delivery

et al. 2022

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“…The fixed weight (100 mg) of tablets was directly compressed using 6.35 mm flat punches. The compression force was set at 4N for minimizing the effect of physical parameters on drug dissolution. , …”

Section: Tablet Preparationmentioning

confidence: 99%

“…The compression force was set at 4N for minimizing the effect of physical parameters on drug dissolution. 34 , 35 …”

Section: Tablet Preparationmentioning

confidence: 99%

New Excipient For Oral Drug Delivery: CNC Derived From Sugarcane Bagasse-Derived Microcrystalline Cellulose

Mishra

2024

ACS Omega

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Nanocrystalline cellulose (CNC) has emerged as a subject of researcher’s interest because of its diverse attributes encompassing biocompatibility, sustainability, a high aspect ratio, and an abundance of −OH groups suitable for modifications. Sugarcane bagasse microcrystalline cellulose (SCBMCC) was used as the raw material for the preparation of CNC due to its pure cellulose content, which is mildly compromised by the pectin, hemicellulose, lignin, and other lignocellulosic components. In the present work, CNC was extracted from SCBMCC and used as a disintegrant. The classic hydrolysis technique was used for the preparation of CNC. Hydrolytic conditions were optimized using the response surface methodology (RSM). The optimized batch of CNC was characterized using techniques such as field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy. Notably, CNC prepared under a hydrolysis time of 90 min exhibited the highest crystallinity of 69.9%. The average particle size and zeta potential were found to be 145 nm and −34.4 mV, respectively. Thermal analysis suggested that an intermediate hydrolysis time resulted in CNC with enhanced thermal stability, showcasing its potential for pharmaceutical applications. Diclofenac potassium was used as the model drug to evaluate the disintegrant properties of CNC as an excipient. Tablets were prepared using the direct compression method. SCBMCC and CNC were used as disintegrants and were compared with the commercial product. The disintegration times (DTs) attained for the tablets prepared using CNC and SCBMCC are 219 and 339.83 s, respectively. The dissolution study of CNC showed a dissolution efficacy (DE%) of 66 and a mean dissolution time (MDT) of 12. The research findings showed that tablets prepared using CNC as disintegrants exhibited the fastest disintegration compared to other formulations.

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Pharmaceutical and Biomedical Applications of Bio-Based Excipients

Singh

Chunglok

2022

Biopolymers Towards Green and Sustainable Development

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The success of an active pharmaceutical depends on how efficiently and precisely the polymeric dosage form can deliver it for effective treatment. Polymers are recognized as inactive pharmaceutical excipients and the backbone of the drug delivery system that plays an essential role in the design of dosage forms. Biodegradable polymer-based drug delivery system has gained significant attention among researchers and manufacturers in the last few decades, compared to synthetic non-biodegradable and their analog polymers. Synthetic biodegradable biopolymers demonstrate excellent efficacy in the design and development of drug delivery that enables the incorporation of active pharmaceuticals into the body. Despite the wide effectiveness of currently available polymers in the design of drug delivery systems, the quest for biocompatible, biodegradable, and easily accessible novel polymers with multifarious applications is still protractile. Due to safety and regulatory approval requirements in the development of novel inactive pharmaceuticals, the introduction of new excipients is much limited. However, the development of bio-based polymers with modification as required could be a valuable way to address the problem associated with synthetic polymers. In this chapter, an overview has been presented on the various applications of bio-based polymers ranging from oral conventional drug delivery to reduction and capping of metallic materials. Moreover, details are presented on the technology-based use of biopolymers in the fabrication of modified oral drug delivery, microneedles, packaging film, and biogenic synthesis of metallic nanoparticles.

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Bio-based Polymer Isolated from Seeds of Buchanania lanzan Spreng with Potential Use as Pharmaceutical Mucoadhesive Excipient

Cited by 4 publications

References 0 publications

Studies on Jackfruit–Okra Mucilage-Based Curcumin Mucoadhesive Tablet for Colon Targeted Delivery

Studies on Jackfruit–Okra Mucilage-Based Curcumin Mucoadhesive Tablet for Colon Targeted Delivery

New Excipient For Oral Drug Delivery: CNC Derived From Sugarcane Bagasse-Derived Microcrystalline Cellulose

Pharmaceutical and Biomedical Applications of Bio-Based Excipients

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