Bio-inspired hydroxyapatite dual core-shell structure for bone substitutes

Chamary, Shaan; Hautcoeur, Dominique; Hornez, Jean‐Christophe; Leriche, Anne; Cambier, F.

doi:10.1016/j.jeurceramsoc.2017.05.043

Cited by 15 publications

(13 citation statements)

References 17 publications

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“…Investigating the literature revealed that the temperature of extraction varied from 250 to 900 C [265,266], however two former studies foregone a dedicated debinding stage [267,268], and a multi-stage temperature approach has been previously incorporated [269][270][271]. Hitherto heating rates varied from 0.3 to 15 C/min [261,272], however the latter is seldom used with numerous researchers opting for a rate of 3 C/min or below [255,265,270,[273][274][275]. Regarding the dwell time, this ranged from 0.5 [265] to 20 [276] hours, with a dwell time of 4 hours or less most frequently selected [255,269,275,277].…”

Section: Removal Of the Organic Additivesmentioning

confidence: 99%

Porous hydroxyapatite scaffolds fabricated from nano-sized powder via honeycomb extrusion

Elbadawi¹

2017

Adv. Mater. Lett.

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Section: Removal Of the Organic Additivesmentioning

confidence: 99%

Porous hydroxyapatite scaffolds fabricated from nano-sized powder via honeycomb extrusion

Elbadawi¹

2017

Adv. Mater. Lett.

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“…% dry matter content, R.T Vanderbilt Co., USA). Mixing took place in a milling jar for 1 h. Slurry was then transferred to a beaker under magnetic stirring for the addition of adjuvants [ 33 ]. The slurry was poured over the scaffold until its complete immersion in a plaster mould.…”

Section: Methodsmentioning

confidence: 99%

“…Before placing it at the centre of the freeze casting mould, a small volume of suspension was poured at −20 °C. After, more suspension was added until the complete submersion of the scaffold [ 33 ]. The same freezing procedure was followed as previously described.…”

Section: Methodsmentioning

confidence: 99%

“…In this study, we analysed the stem cell behaviour in response to different porosity morphologies and distributions in both HA and β-TCP ceramic bone scaffolds that mimic in detail both the spongy and cortical bone tissue architecture. The spongy-like scaffold was prepared by replica technique from polymer beads, and the cortical-like scaffold via freeze casting [ 33 ]. A perfusion bioreactor was used as predictive tool to better replicate the physiological human body process and it allows long term cell culture in vitro.…”

Section: Introductionmentioning

confidence: 99%

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Bone-like ceramic scaffolds designed with bioinspired porosity induce a different stem cell response

Panseri

Montesi

Hautcoeur

et al. 2021

J Mater Sci: Mater Med

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Biomaterial science increasingly seeks more biomimetic scaffolds that functionally augment the native bone tissue. In this paper, a new concept of a structural scaffold design is presented where the physiological multi-scale architecture is fully incorporated in a single-scaffold solution. Hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) bioceramic scaffolds with different bioinspired porosity, mimicking the spongy and cortical bone tissue, were studied. In vitro experiments, looking at the mesenchymal stem cells behaviour, were conducted in a perfusion bioreactor that mimics the physiological conditions in terms of interstitial fluid flow and associated induced shear stress. All the biomaterials enhanced cell adhesion and cell viability. Cortical bone scaffolds, with an aligned architecture, induced an overexpression of several late stage genes involved in the process of osteogenic differentiation compared to the spongy bone scaffolds. This study reveals the exciting prospect of bioinspired porous designed ceramic scaffolds that combines both cortical and cancellous bone in a single ceramic bone graft. It is prospected that dual core shell scaffold could significantly modulate osteogenic processes, once implanted in patients, rapidly forming mature bone tissue at the tissue interface, followed by subsequent bone maturation in the inner spongy structure.

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“…Inspired by those examples of natural tissues, the development of artificial implants with graded structures and functionalities is nowadays increasing . Table gives an overview of different FGCs developed in the biomedical field with their main applications …”

Section: Rationale For the Use Of Fgcs In The Biomedical Fieldmentioning

confidence: 99%

Functionally graded ceramics for biomedical application: Concept, manufacturing, and properties

Petit

Montanaro

Palmero

2018

Int J Applied Ceramic Tech

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Functionally Graded Materials (FGMs) represent a novel approach for the realization of innovative properties and/or functions that conventional homogeneous materials cannot accomplish. In conventional materials, in fact, the composition or the structure is uniform over the volume; on the opposite, in FGMs such features gradually change from layer to layer, with the aim of realizing a gradation of properties over the volume and performing a set of specified functions. Among FGMs, special attention is given today to Functionally Graded Ceramics (FGCs), designed and developed to withstand a variety of severe operative conditions, including high temperatures, corrosive environments, abrasion, mechanical, and thermal induced stresses. An important application field of FGCs is for medical prosthetic devices and artificial tissues, taking inspiration from the several examples of living tissues with graded structures. After an introduction on the rationale for using FGCs in the biomedical field, the 3 main types of graded materials developed today (eg, composition, porosity and microstructural graded ceramics) are here reviewed, highlighting the most innovative technologies used to develop them, their potentials and challenging features in comparison with the monolithic counterparts. K E Y W O R D S

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Bio-inspired hydroxyapatite dual core-shell structure for bone substitutes

Cited by 15 publications

References 17 publications

Porous hydroxyapatite scaffolds fabricated from nano-sized powder via honeycomb extrusion

Porous hydroxyapatite scaffolds fabricated from nano-sized powder via honeycomb extrusion

Bone-like ceramic scaffolds designed with bioinspired porosity induce a different stem cell response

Functionally graded ceramics for biomedical application: Concept, manufacturing, and properties

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