<div>A reliable toolchain for the validation and evaluation of numerical spray break-up simulation for the potentially carbon-neutral fuels polyoxymethylene dimethylether (POMDME, or short OME) is developed and presented. The numerical investigation is based on three-dimensional computational fluid dynamics (3D-CFD) with the commercial code STAR-CD v2019.1 using a Reynolds-averaged Navier-Stokes (RANS) equations approach. Fuel properties of the representatives OME<sub>1</sub> and OME<sub>3</sub> are implemented into the software and with that the fuels are investigated numerically.</div> <div>For validation purposes, optical experimental results in a heated spray chamber with inert nitrogen-pressurized atmosphere are presented. The measurement data are based on Mie scattering of the liquid phase and Schlieren imaging of the vapor phase. Solely experimental results are shown for OME<sub>1b</sub> and OME<sub>3–6</sub> to assess if the knowledge from the numerical modeling with OME<sub>1</sub> and OME<sub>3</sub> can also be transferred to the corresponding multicomponent fuels. While the results for a match between OME<sub>3</sub> and OME<sub>3–6</sub> are close, the measurement for OME<sub>1b</sub> exceeds the result of OME<sub>1</sub> in the liquid penetration significantly. This is explained by the molecular structure of the low-volatile additive in OME<sub>1b</sub> based on long-chained polyglycol ethers. For the numerically modeled operating conditions, the fuel injection rate with the corresponding fuel is measured. Two atomization and spray break-up approaches are investigated in simulation, based on Reitz-Diwakar (RD) models and a combination using Huh’s atomization and the Kelvin-Helmholtz Rayleigh-Taylor (KHRT) spray break-up models. A holistic parameter study in a single operating point with the fuel OME<sub>1</sub> helps to determine the sensitivities of the models. Adjustments to the spray momentum by a variation of the parameter for the nozzle hole diameter are used to get results closely aligned with measurement data. The transfer of the calibrated RD model to a validation study with OME<sub>3</sub> at different operating conditions matches well to measurement with no further adjustments necessary.</div>
