Bio-plastic Polyhydroxyalkanoate (PHA): Applications in Modern Medicine

Mukheem, Abdul; Shahabuddin, Syed; Khan, Aleem Ahmed; Hossain, Murad; Jasni, Ainil Hawa; Sridewi, Nanthini

doi:10.1007/978-981-16-1823-9_8

Cited by 5 publications

(4 citation statements)

References 140 publications

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“…One example is their biocompatibility, which refers to their ability to maintain adequate cellular function while evoking no inflammatory reactions in the host. They are also nontoxic and entirely biodegradable. , Some PHA materials, however, suffer from poor physicochemical qualities and high manufacturing costs. These disadvantages necessitate deliberate efforts to enhance PHA characteristics and lower PHA manufacturing costs.…”

Section: Poly(hydroxyalkanoates (Pha) Origin Types Properties and Bio...mentioning

confidence: 99%

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Poly(hydroxyalkanoates): Production, Applications and End-of-Life Strategies–Life Cycle Assessment Nexus

Muiruri

Yeo

Zhu

et al. 2022

ACS Sustainable Chem. Eng.

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The runaway production and consumption of oilbased plastics are key drivers of global warming and the increased carbon footprint. Besides, most of this plastic debris ends up in the oceans and constitutes about 80% of all marine debris. This pollution problem calls for a seismic shift to eco-friendly plastics and marine biodegradable ones. Unlike other biobased polymers, polyhydroxyalkanoates (PHAs) take pride in their degradation in soil and marine environments. This intriguing marine biodegradation property of PHAs sets it apart as the best choice to curb microplastics, particularly in marine ecosystems. PHAs have also grown in popularity due to other quintessential properties such as biocompatibility, structural variety, and similarity to conventional plastics in terms of physical properties. PHAs are being widely researched for various applications, including packaging, medical, energy, and agriculture. This perspective comprehensively focuses on the state-of-art production and applications of PHA plastics as well as the practical recycling strategies for postconsumer PHAs. The innovative "next generation industrial biotechnology" (NGIB) is well covered in this perspective. Moreover, the nexus between end-of-life strategies and life cycle assessment (LCA) of PHAs waste is elucidated to understand its impact on the environment thoroughly.

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Section: Poly(hydroxyalkanoates (Pha) Origin Types Properties and Bio...mentioning

confidence: 99%

“…They are also nontoxic and entirely biodegradable. 131,132 Some PHA materials, however, suffer from poor physicochemical qualities and high manufacturing costs. These disadvantages necessitate deliberate efforts to enhance PHA characteristics and lower PHA manufacturing costs.…”

Section: ■ Introduction Of Bioplasticsmentioning

confidence: 99%

Poly(hydroxyalkanoates): Production, Applications and End-of-Life Strategies–Life Cycle Assessment Nexus

Muiruri

Yeo

Zhu

et al. 2022

ACS Sustainable Chem. Eng.

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“…More importantly, the degradation time of the material matches the time of tissue growth, allowing the implant material to be replaced by its own tissue within a certain period. [6][7][8][9][10][11][12][13] Therefore, PHAs have been widely studied as tissue engineering materials and drug delivery matrices. As an extended family, the general structure of PHAs is shown in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

“…Meanwhile, the strength, hardness, and elastic modulus of PHAs matches with the implanted hard tissue. More importantly, the degradation time of the material matches the time of tissue growth, allowing the implant material to be replaced by its own tissue within a certain period 6–13 . Therefore, PHAs have been widely studied as tissue engineering materials and drug delivery matrices.…”

Section: Introductionmentioning

confidence: 99%

Electrospinning nanofibers of microbial polyhydroxyalkanoates for applications in medical tissue engineering

Zhao

Niu

et al. 2021

Journal of Polymer Science

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Differently to most chemically synthesized medical materials, polyhydroxyalkanoates (PHAs) are intracellular carbon and energy storage granules, which is a family of natural bio-polymers synthesized by microorganism's materials. Due to excellent biocompatibility reasonable biodegradability and versatile material difference, PHAs are well medical biomaterials candidates for applications in tissue engineering and drug delivery, including commercial PHB, PHBV, PHBHHx, PHBVHHx, P34HB and few uncommercial PHAs.Electrospinning nanofibers with the size of 10-10,000 nm can improve the mechanical properties and decrease the crystallinity of PHA, meanwhile simulate the structure and function of native extracellular matrix of cells. Hence, PHAs electrospinning nanofibers as engineered scaffolds have been widely used for tissue engineering scaffolds in cardiovascular, vascular, nerve, bone, cartilage and skin; also, as carriers for application in drug delivery system. In this review, we highlight the extraction and properties of medical PHAs from natural or engineered microorganism, and microstructure, current manufacturing techniques and medical applications of electrospinning nanofibers of PHAs. Moreover, the current challenges and prospects of PHAs electrospinning nanofibers are discussed rationally, providing an insight into developing vibrant fields of PHAs electrospinning nanofibers-based biomedicine.

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Possible Applications of Developed Bioplastics

Gbadeyan,

Deenadayalu

2024

Biomass-Based Bioplastic and Films

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Bio-plastic Polyhydroxyalkanoate (PHA): Applications in Modern Medicine

Cited by 5 publications

References 140 publications

Poly(hydroxyalkanoates): Production, Applications and End-of-Life Strategies–Life Cycle Assessment Nexus

Poly(hydroxyalkanoates): Production, Applications and End-of-Life Strategies–Life Cycle Assessment Nexus

Electrospinning nanofibers of microbial polyhydroxyalkanoates for applications in medical tissue engineering

Possible Applications of Developed Bioplastics

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