Bio-responsive and multi-modality imaging nanomedicine for osteoarthritis theranostics

Xue, Song; Ruan, Guangfeng; Li, Jia; Madry, Henning; Zhang, Chao; Ding, Changhai

doi:10.1039/d3bm00370a

Cited by 3 publications

(1 citation statement)

References 128 publications

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“…[ 196,197 ] Similarly, protease‐responsive nanomaterials are also developed to release their therapeutic payloads in response to the activity of specific enzymes, such as metalloproteinases, which are upregulated in OA‐affected joint. [ 198,199 ] These smart response mechanisms ensure that the drug release is not only precisely targeted but also temporally controlled, aligning drug availability with the pathological state of the joint.…”

Section: Multifunctional Nanomaterials For Oa Therapymentioning

confidence: 99%

Intra‐Articular Injection of Nanomaterials for the Treatment of Osteoarthritis: From Lubrication Function Restoration to Cell and Gene Therapy

Yang,

Zhang

2024

Adv Funct Materials

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Osteoarthritis (OA), a prevalent joint disease affecting many people globally, presents significant challenge in current treatments, which often only manage symptoms without halting disease progression. This review illuminates novel approaches in OA therapy, focusing mainly on intra‐articular injection of nanomaterials. The innovative materials, designed to either mimic or augment natural joint lubrication, show promise in restoring joint biomechanics and alleviating pain. The review delves into an array of biomimetic lubricants, including polymer brush, nanocomposite hydrogel, and nanoparticles, underscoring their roles in anti‐inflammation, targeting, cartilage repair, and drug delivery. Furthermore, the potential of mesenchymal stem cells to differentiate into chondrocytes, coupled with the delivery of these cells and their exosomes via nanomaterials, has promoted cell therapy avenues for OA. The review also highlights the function of non‐coding RNAs such as miRNA, siRNA, circRNA, lncRNA, and antisense oligonucleotides in impeding OA progression, with nanomaterials facilitating their delivery, thus facilitating advanced therapeutic possibilities including immune evasion and bone cell proliferation. Overall, this review encapsulates the evolution of nanomaterials in OA treatment from material to cell, and ultimately to gene therapy, forecasting a future where nanomaterials evolve toward integrated, personalized diagnostics and therapeutics for OA.

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Section: Multifunctional Nanomaterials For Oa Therapymentioning

confidence: 99%

Intra‐Articular Injection of Nanomaterials for the Treatment of Osteoarthritis: From Lubrication Function Restoration to Cell and Gene Therapy

Yang,

Zhang

2024

Adv Funct Materials

View full text Add to dashboard Cite

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Biomaterial-based scaffolds in promotion of cartilage regeneration: Recent advances and emerging applications

Liang,

Liu,

Yang

et al. 2023

Journal of Orthopaedic Translation

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Nanomedicine: Innovative Strategies and Recent Advances in Targeted Cancer Therapy

Gautam,

Mittal,

Goyal

et al. 2024

CMC

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Nanomedicine's application of nanotechnology in medicine holds tremendous potential for diagnosing and treating life-threatening diseases such as cancer. Unlike conventional therapies, nanomedicine offers a promising strategy to enhance clinical outcomes while minimizing severe side effects. The principle of drug targeting enables specific delivery of therapeutic agents to their intended sites, making it a more precise and effective therapy. Combination strategies, such as the co-delivery of chemotherapeutic drugs with nucleic acids or receptor-specific molecules, are being employed to enhance therapeutic outcomes. Nanocarriers and drug delivery systems designed using these approaches offer resourceful co-delivery of therapeutic agents for anticancer therapy. Targeted drug delivery via nanotechnology-based techniques has become an urgent need and has shown significant improvements in therapeutic implications, pharmacokinetics, specificity, reduced toxicity, and biocompatibility. This review discusses the extrapolation of nanomaterials for developing innovative and novel drug delivery systems for effective anticancer therapy. Additionally, we explore the role of nanotechnology-based concepts in drug delivery research.

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Bio-responsive and multi-modality imaging nanomedicine for osteoarthritis theranostics

Abstract: Stimuli-responsive nanoplatforms combined with targeting strategy for precise osteoarthritis theranostics based on inherent and microenvironment traits.

Cited by 3 publications

References 128 publications

Intra‐Articular Injection of Nanomaterials for the Treatment of Osteoarthritis: From Lubrication Function Restoration to Cell and Gene Therapy

Intra‐Articular Injection of Nanomaterials for the Treatment of Osteoarthritis: From Lubrication Function Restoration to Cell and Gene Therapy

Biomaterial-based scaffolds in promotion of cartilage regeneration: Recent advances and emerging applications

Nanomedicine: Innovative Strategies and Recent Advances in Targeted Cancer Therapy

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