Bioabsorbable magnesium versus standard titanium compression screws for fixation of distal metatarsal osteotomies – 3 year results of a randomized clinical trial

Plaaß, Christian; Falck, Christian von; Ettinger, Sarah; Sonnow, Lena; Calderone, Franco; Weizbauer, Andreas; Reifenrath, Janin; Claaßen, Leif; Waizy, Hazibullah; Daniilidis, Kiriakos; Windhagen, Henning

doi:10.1016/j.jos.2017.11.005

Cited by 105 publications

(96 citation statements)

References 26 publications

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“…Magnesium‐based implants can even promote bone growth, while the degraded magnesium is absorbed and replaced by new bone tissue (Mueller et al, ; Xu et al, ). Studies to investigate the clinical results after hallux valgus treatment with a magnesium‐based screw compared to a standard titanium screw verified the benefits of bioresorbable implants and did not find any foreign‐body reactions (Plaass et al, ; Windhagen et al, ). Foreign metals in the body—such those of permanent implants—can cause undesirable bodily reactions due to submicroscopic wear particles and corrosion products (Willert et al, ).…”

Section: Results Of Empirical Investigationmentioning

confidence: 97%

“…Apart the two main current human applications like drug‐eluting vascular stents (Haude et al, ) and orthopedics in form of compression screws and pins (Plaass et al, ), magnesium is under investigation as membrane material for dental and facial surgeries. Bioactive and degradable magnesium foils show a higher mechanical stability compared to common collagen foils and could be used, for example, in periodontal surgeries to stabilized weak tissue and to support the controlled bone growth (Hornberger, Striegl, Trahanofsky, Kneissl, & Kronseder, ).…”

Section: Resultsmentioning

confidence: 99%

“…Apart the two main current human applications like drug-eluting vascular stents (Haude et al, 2016) and orthopedics in form of compression screws and pins (Plaass et al, 2018), magnesium is under investigation as membrane material for dental and facial surgeries.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, researchers have been extensively investigating various applications of magnesium alloys, including orthopedic or vascular implants. The first two product categories to have been introduced into the market were biodegradable magnesium-based screws by Syntellix (Plaass et al, 2018) and stents by Biotronik (Haude et al, 2016), whereby the market for biomaterials will continue to grow. In 2018, Research and Markets published a global biomaterials market overview and estimated metal biomaterials as the most common material type (Research and Markets, 2018).…”

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confidence: 99%

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Development of magnesium implants by application of conjoint‐based quality function deployment

Siefen

Höck

2019

J Biomedical Materials Res

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Biodegradable magnesium‐based implants are the subject of a great deal of research for different orthopedic and vascular applications. The targeted design and properties depend on the specific medical function and location in the body. Development of the biomaterial requires a comprehensive understanding of the biological interaction between the implant and the host tissue, as well as of the behavior in the physiological environment in vivo. Research into and the development of innovative magnesium implants entails interdisciplinary research efforts and communication between materials science, bioscience, and medical experts. The present study provides a transparent planning and communication tool for market‐oriented implant development processes. The objective was to identify medical needs at an early stage of the development process and to quantify the importance of the engineering characteristics of different research fields that cater to specific implant requirements. The method is demonstrated by the performance of a survey‐based conjoint analysis, which was integrated into a quality function deployment approach. Twenty‐seven medical professionals and 29 biomaterial scientists assessed the importance of identified medical requirements, whereby the control of mechanical integrity and degradation along with nontoxicity and nonimmunogenicity showed the highest number of preferences. The evaluation of implant options by 31 experts indicated that the engineering characteristic with the highest importance was the condition and sterilization of the surface. These values can be used to set priorities in strategic decisions. Research trials can be aligned to medical preferences, ensuring high product quality and an effective development process. This is the first paper to report on the application of conjoint‐based quality function deployment in biomaterial research.

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Section: Results Of Empirical Investigationmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Development of magnesium implants by application of conjoint‐based quality function deployment

Siefen

Höck

2019

J Biomedical Materials Res

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“…This could be favorable as it would reduce implantassociated stress shielding and bone degradation [90,91]. Magnesium-based screws have been used in bone healing clinical trials without notable side effects reported by patients [92,93]. The first commercial magnesium screws (Magnezix, Syntellix, Hannover, Germany) were available in 2013, and completely disappeared one to two years after implantation [94].…”

Section: Characteristics Of Magnesium-based Implantsmentioning

confidence: 99%

Advances and Challenges of Biodegradable Implant Materials with a Focus on Magnesium-Alloys and Bacterial Infections

Rahim¹,

Ullah²,

Mueller³

2018

Preprint

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Medical implants made of biodegradable materials could be advantageous for temporary applications, such as mechanical support during bone-healing or as vascular stents to keep blood vessels open. After completion of the healing process, the implant would disappear, avoiding longterm side effects or the need for surgical removal. Various corrodible metal alloys based on magnesium, iron or zinc have been proposed as sturdier and potentially less inflammatory alternatives to degradable organic polymers, in particular for load-bearing applications. Despite the recent introduction of magnesium-based screws, the remaining hurdles to routine clinical applications are still challenging. These include limitations such as mechanical material characteristics or unsuitable corrosion characteristics. In this article, the salient features and clinical prospects of currently-investigated biodegradable implant materials are summarized, with a main focus on magnesium alloys. A mechanism of action for the stimulation of bone growth due to the exertion of mechanical force by magnesium corrosion products is discussed. To explain divergent in vitro and in vivo effects of magnesium, a novel model for bacterial biofilm infections is proposed which predicts crucial consequences for antibacterial implant strategies.

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Surgical interventions for treating hallux valgus and bunions

Dias,

Godoy-Santos,

Ferrari

et al. 2024

Cochrane Database of Systematic Reviews

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Bioabsorbable magnesium versus standard titanium compression screws for fixation of distal metatarsal osteotomies – 3 year results of a randomized clinical trial

Cited by 105 publications

References 26 publications

Development of magnesium implants by application of conjoint‐based quality function deployment

Development of magnesium implants by application of conjoint‐based quality function deployment

Advances and Challenges of Biodegradable Implant Materials with a Focus on Magnesium-Alloys and Bacterial Infections

Surgical interventions for treating hallux valgus and bunions

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