Bioaccessibility as a determining factor in the bioavailability and toxicokinetics of cadmium compounds

Poland, Craig A.; Lombaert, Noömi; Mackie, Carol; Renard, Alain; Sinha, Parikhit; Verougstraete, Violaine; Lourens, Nicky

doi:10.1016/j.tox.2021.152969

Cited by 11 publications

(2 citation statements)

References 35 publications

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“…BA refers to simulation of the gastrointestinal uptake to determine the fraction of ingested compound that is potentially available for absorption, which is a determining factor in the bioavailability and toxicokinetics of Cd compounds . The in vitro digestion result showed that there was a significant difference ( p < 0.05) among the cultivars in terms of oil Cd BA (Figure b), which ranged from 2.48 to 30.6% (the mean value 15%).…”

Section: Resultsmentioning

confidence: 99%

Cadmium Distribution, Availability, and Translocation in Soil-Oilseed Rape (Brassica napus L.) System and Its Risk Assessment

Zhang

Tao

Nie

et al. 2022

ACS Earth Space Chem.

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Proper utilization of lightly contaminated farmlands is popular for developing countries such as China where there are high demands for food production to meet the needs of high population in the limited available arable lands. Oilseed rape (Brassica napus L.) is an important oil crop as well as a potential candidate for soil Cd remediation. Dietary oil ingestion is the main route of human exposure to cadmium (Cd). Therefore, understanding the characteristics of Cd transfer in the soil-oilseed rape system and its human health risk assessment are crucial for health risk alleviation and pollution control. A field experiment was conducted with 25 oilseed rape cultivars grown in a Cd (1.59 mg kg −1 )-contaminated farmland where Cd was mainly from former mining activities in nearby mountains. Results showed that Cd concentrations in oilseed rape were in the order of shoots > roots > pods > seeds. The mean values of both transfer factors and bioaccumulation factors were higher than 1. Residual Cd fraction accounted for the largest proportion of the four solid components (fractions) of Cd. Cd concentration in oil ranged from 0.004 to 0.06 mg kg −1 . In vitro digestion study showed that the bioaccessibility of Cd in rapeseed oil ranged from 2.48 to 30.6%. The target hazard quotients of Cd and hazard index via oil intake were below 1, and the incremental lifetime cancer risks of Cd were within the required values of 1 × 10 −6 −1 × 10 −4 . This study suggests the safety limit of Cd in rapeseed oil as 0.18 mg kg −1 based on the comparison of the carcinogenic and noncarcinogenic risks. Conclusively, oilseed rape has a good Cd accumulation capability, but the most grain Cd in plants grown in the lightly Cd-polluted soil remained non-bioaccessible with a negligible noncarcinogenic risk and an acceptable level of carcinogenic risk to human health.

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Section: Resultsmentioning

confidence: 99%

Cadmium Distribution, Availability, and Translocation in Soil-Oilseed Rape (Brassica napus L.) System and Its Risk Assessment

Zhang

Tao

Nie

et al. 2022

ACS Earth Space Chem.

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“…Bioaccessibility represents potentially available components, and bioavailability reflects differences in bioaccessibility [ 62 ]. Simulated human gastrointestinal digestion experiments, in vitro cell culture experiments, and mouse experiments are often used to evaluate bioaccessibility and bioavailability.…”

Section: Bioaccessibility and Bioavailability Of Se-enriched Proteins...mentioning

confidence: 99%

A Review of Plant Selenium-Enriched Proteins/Peptides: Extraction, Detection, Bioavailability, and Effects of Processing

Xiong

Huang

et al. 2023

Molecules

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As an essential trace element in the human body, selenium (Se) has various physiological activities, such as antioxidant and anticancer activity. Selenium-enriched proteins/peptides (SePs/SePPs) are the primary forms of Se in plants and animals, and they are the vital carriers of its physiological activities. On the basis of current research, this review systematically describes the extraction methods (aqueous, alkaline, enzymatic, auxiliary, etc.) and detection methods (HPLC–MS/MS, GC–ICP-MS, etc.) for SePs/SePPs in plants. Their bioavailability and bioactivity, and the effect of processing are also included. Our review provides a comprehensive understanding and theoretical guidance for the utilization of selenium-enriched proteins/peptides.

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A comprehensive review of cadmium-induced toxicity, signalling pathways, and potential mitigation strategies

Vijiyakumar,

Prince

2024

Toxicol. Environ. Health Sci.

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Bioaccessibility as a determining factor in the bioavailability and toxicokinetics of cadmium compounds

Cited by 11 publications

References 35 publications

Cadmium Distribution, Availability, and Translocation in Soil-Oilseed Rape (Brassica napus L.) System and Its Risk Assessment

Cadmium Distribution, Availability, and Translocation in Soil-Oilseed Rape (Brassica napus L.) System and Its Risk Assessment

A Review of Plant Selenium-Enriched Proteins/Peptides: Extraction, Detection, Bioavailability, and Effects of Processing

A comprehensive review of cadmium-induced toxicity, signalling pathways, and potential mitigation strategies

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