2021
DOI: 10.3389/fmats.2021.734683
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Bioactive 3D Scaffolds for the Delivery of NGF and BDNF to Improve Nerve Regeneration

Abstract: Peripheral nerve injury is an important cause of disability, that can hinder significantly sensory and motor function. The clinical gold standard for peripheral nerve repair is the use of autografts, nevertheless, this method has limitations such as donor site morbidity. An emerging alternative to autografts are nerve guide conduits, which are used to entubulate the severed nerve and provide guidance for the directed regeneration of the nerve tissue. These nerve guide conduits are less effective than autograft… Show more

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Cited by 10 publications
(20 citation statements)
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“…Moreover, the neurite outgrowth was significantly enhanced on the eFM-NGF systems, especially on the eFM-pNGF system. These results were consistent with recent studies where electrospun nanofibrous scaffolds releasing NGF enhanced neural cell commitment [ 33 , 34 , 35 , 36 , 37 ]. However, the stimulation of neurite outgrowth and neural differentiation on different neurotrophic factor-containing scaffolds varied between works.…”
Section: Discussionsupporting
confidence: 93%
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“…Moreover, the neurite outgrowth was significantly enhanced on the eFM-NGF systems, especially on the eFM-pNGF system. These results were consistent with recent studies where electrospun nanofibrous scaffolds releasing NGF enhanced neural cell commitment [ 33 , 34 , 35 , 36 , 37 ]. However, the stimulation of neurite outgrowth and neural differentiation on different neurotrophic factor-containing scaffolds varied between works.…”
Section: Discussionsupporting
confidence: 93%
“…Among them, neurotrophic factors are an important group of bioactive molecules that stimulate and promote the proliferation of non-neuronal cells, as well as the sprouting/growth of injured sensory, motor, and postganglionic sympathetic axons from the proximal nerve stump [ 23 , 32 ]. Nerve growth factor (NGF) is one of the most prominent and commonly used neurotrophic factor for peripheral nerve regeneration [ 18 , 25 , 31 , 33 , 34 , 35 , 36 , 37 ]. It acts as a chemoattractant, which may regulate the proliferation and differentiation of cells, and the myelination of neurons [ 38 ].…”
Section: Introductionmentioning
confidence: 99%
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“…Chick dorsal root ganglia (DRGs) were extracted from E12 chick embryos, in compliance with U.K. Home Office Animals Scientific Procedures Act 1986, as previously described by Sandoval-Castellanos et al (2020). 20 The nerve roots were trimmed, and one DRG body was placed onto each sample condition and left to attach for 30 min. Warm supplemented DMEM containing 10% fetal calf serum was gently added into the well plates, and DRGs were incubated for 7 days at 37 °C/5% CO 2 .…”
Section: Chorioallantoic Membrane Studies (Cam Studies)mentioning
confidence: 99%
“…The release of individual growth factors resulted in a greater neurite extension and SC migration than simultaneous release. Probably, this difference is due to the higher affinity of receptors for NGF compared to BDNF in a chicken embryo DRG [ 79 ].…”
Section: Drug Delivery System For Peripheral Nerve Regenerationmentioning
confidence: 99%