Bioactive cembranoids from the Red Sea soft coral Sarcophyton glaucum

Ross, Samir A.; El-Ezz, RF Abou; Ahmed, SA; Radwan, MM; Ayoub, NA; Afifi,; Khalifa, Sherief

doi:10.1055/s-0032-1320701

Cited by 2 publications

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“…Cembranoid diterpene, identified as (1S,2E,4R,6E,8S,11R,12S)-8,11-epoxy-4,12-epoxy-2,6cembradiene 175, (1S,2E,4R,6E,8R,11S,12R)-8,12-epoxy-2,6-cembradiene-4,11-diol 176, and (1S,4R,13S)-cembra-2E,7E,11E-trien-4,13-diol 177, were reported from nature for the first time, from S. glaucum [68].…”

Section: Introductionmentioning

confidence: 94%

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Chemical Diversity in Species Belonging to Soft Coral Genus Sacrophyton and Its Impact on Biological Activity: A Review

et al. 2020

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One of the most widely distributed soft coral species, found especially in shallow waters of the Indo-Pacific region, Red Sea, Mediterranean Sea, and also the Arctic, is genus Sacrophyton. The total number of species belonging to it was estimated to be 40. Sarcophyton species are considered to be a reservoir of bioactive natural metabolites. Secondary metabolites isolated from members belonging to this genus show great chemical diversity. They are rich in terpenoids, in particular, cembranoids diterpenes, tetratepenoids, triterpenoids, and ceramide, in addition to steroids, sesquiterpenes, and fatty acids. They showed a broad range of potent biological activities, such as antitumor, neuroprotective, antimicrobial, antiviral, antidiabetic, antifouling, and anti-inflammatory activity. This review presents all isolated secondary metabolites from species of genera Sacrophyton, as well as their reported biological activities covering a period of about two decades (1998–2019). It deals with 481 metabolites, including 323 diterpenes, 39 biscembranoids, 11 sesquiterpenes, 53 polyoxygenated sterols, and 55 miscellaneous and their pharmacological activities.

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Section: Introductionmentioning

confidence: 94%

“…Good antidiabetic activity with IC 50 = 15.4µM. Strong antibacterial activity toward methicillin-sensitive S. aureus Newman strain with MIC = 125 µg/mL[40,41,68].…”

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confidence: 99%