Bioactive components and antioxidant, antiproliferative, and antihyperglycemic activities of wild cornelian cherry (Cornus mas l.)

Abstract

The contents of polyphenolic components (total polyphenols, flavonoids, and monomeric anthocyanins) and vitamin C, and the bioactive potential (antioxidant, antiproliferative, and antihyperglycemic activities) of wild cornelian cherry were determined. Samples were collected from four different locations in Bosnia and Herzegovina. Sample CC3 from Drinić had the highest monomeric anthocyanin content (1.40 mg CyGE/g FW) and the highest inhibition of free radicals (IC50 DPPH = 262.19 mg/ml; IC50 ABTS = 76.78 mg/ml; IC50 OH˙ = 102.31 mg/ml) and inhibition of breast adenocarcinoma cell line growth (IC50 MCF-7 = 1.37 mg/ml). Sample CC4 from Drvar showed the highest total polyphenol (55.92 mg GAE/g DW) and vitamin C (88.74 mg/g FW) contents. Sample CC4 significantly inhibited the growth of cervix epithelioid carcinoma (IC50 HeLa = 0.62 mg/ml) and lung adenocarcinoma (IC50 A549 = 0.48 mg/ml) cell lines, and αglucosidase (IC50 AGHA = 0.466 mg/ml). Wild cornelian cherry could be used as a functional food with beneficial pro-health properties.

Health-Promoting Properties of Anthocyanins from Cornelian Cherry (Cornus mas L.) Fruits

“…Odžaković et al [ 45 ] performed several tests, such as DPPH, ABTS, and OH radical neutralization, to determine the antioxidant capacity of several ecotypes of cornelian cherry growing in various regions of Bosnia and Herzegovina ( Table 1 ). Ecotype CC3 from the Drinić area featured the highest level of monomeric anthocyanins (1.40 mg CyGE·g −1 FW) and the highest capacity of inhibiting free radicals (IC50 DPPH = 262.19 mg·mL −1 ; IC50 ABTS = 76.78 mg·mL −1 ; IC50 OH ˙ = 102.31 mg·mL −1 ).…”

“…Odzankovic et al [ 45 ] examined the antiproliferative properties of extracts from four cornelian cherry ecotypes growing in Bosnia and Herzegovina. Extracts from cornelian cherry with the highest content of monomeric anthocyanins (CC3) and the highest total polyphenol content (CC4) featured the highest capability of inhibiting cell line growth of breast adenocarcinoma, cervical squamous cell carcinoma, and lung adenocarcinoma ( Table 1 ).…”

Polyphenolic Composition and Antimicrobial, Antioxidant, Anti-Inflammatory, and Antihyperglycemic Activity of Different Extracts of Teucrium montanum from Ozren Mountain

“…The total polyphenol content (TPC) of T. montanum extracts was determined in accordance with Odžaković et al [44] by the Folin-Ciocalteu method. The content of polyphenolic compounds was determined by measuring the absorbance with a UV-vis spectrophotometer (Lambda 25, PerkinElmer, Shelton, CT, USA), and the results were expressed as mg of gallic acid equivalent per gram of dry extract (mg GAE/g DW).…”

Physiological characterization of wild cornelian cherry genotypes in terms of phenolic compounds, organic acids and antioxidants

“…In another study, the total polyphenol content was determined between 200 mg/100g − 600 mg/100g (Kucharska et al 2009). In a study conducted in Bosnia and Herzegovina, the highest total phenolic content was found to be 55.92 mg GAE/g in certain samples of cornelian cherry samples from four different locations (Odžaković et al 2021). In a study conducted to investigate the phenolic compounds in cornelian cherry fruit and the antioxidant capacity of the fruit, the total phenolic content in cornelian cherry fruits was determined as 230.4 mg GAE/100g − 559.8 mg GAE/100g (Güzel 2021).…”

“…In a study examining the total anthocyanin content in fresh cornelian cherry fruit, the total amount of anthocyanin in C. mas fruit was determined as 2.11 mg/g − 2.62 mg/g (Zia and Alibas 2021). In a study conducted in Bosnia and Herzegovina, the highest total anthocyanin content was found to be 1.40 mg/g in certain samples of cornelian cherry samples taken from four different locations(Odžaković et al 2021). In a study aimed at the extraction of bioactive compounds in cornelian cherry, the total monomeric anthocyanin content was determined as 0.65 mg/g(Kutlu et al 2021a).…”