Bioactive compound loaded stable silver nanoparticle synthesis from microwave irradiated aqueous extracellular leaf extracts of Naringi crenulata and its wound healing activity in experimental rat model

., T. Bhuvaneswari; Thiyagarajan, M.; Geetha, N.; Venkatachalam, P.

doi:10.1016/j.actatropica.2014.03.009

Cited by 52 publications

(35 citation statements)

References 40 publications

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“…8 (2017) 025001 the synthesized AgNPs (figures 4(a)-(d)). Similar findings on SEM and EDS spectrum analysis were reported for synthesized AgNPs using leaf extracts of Artemisia nilagirica [26], Ficus benghalensis [27], Rauvolfia tetraphylla [28], Caesalpinia coriaria [29] and Naringi crenulata [30]. 3 1 1) sets of lattice planes and it indicates the facecentred cubic (fcc) structure of AgNPs, which are closely linked with Joint committee on powder diffraction standards (JCPDS file no.…”

Section: Green Synthesis and Characterization Of Agnpssupporting

confidence: 55%

Green engineering of biomolecule-coated metallic silver nanoparticles and their potential cytotoxic activity against cancer cell lines

Prasannaraj

Venkatachalam

2017

Adv. Nat. Sci: Nanosci. Nanotechnol.

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This report describes the synthesis of metallic silver nanoparticles (AgNPs) using extracts of four medicinal plants (Aegle marmelos (A. marmelos), Alstonia scholaris (A. scholaris), Andrographis paniculata (A. paniculata) and Centella asiatica (C. asiatica)). The bio-conjugates were characterized by UV-visible spectroscopy, scanning electron microscopyenergy dispersive spectroscopy (SEM-EDS), Fourier transform infrared spectrometry (FTIR), x-ray diffraction (XRD) and zeta potential. This analysis confirmed that UV-Vis spectral peaks at 375 nm, 380 nm, 420 nm and 380 nm are corresponding to A. marmelos, A. scholaris, A. paniculata and C. asiatica mediated AgNPs, respectively. SEM images revealed that all the obtained four AgNPs are predominantly spherical, fibres and rectangle in shape with an average size of 36-97 nm. SEM-EDS and XRD analysis confirmed the presence of elemental AgNPs in crystalline form for all the four nanoparticle samples. The phytochemicals of various medicinal plant extracts with different functional groups were responsible for reduction of Ag + to AgNPs, which act as capping and stabilizing agent. Among four types of AgNPs tested for anticancer activity, the Ap mediated AgNPs had shown enhanced activity against HepG2 cells (27.01 µg ml −1 ) and PC3 cells (32.15 µg ml −1 ).

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Section: Green Synthesis and Characterization Of Agnpssupporting

confidence: 55%

Green engineering of biomolecule-coated metallic silver nanoparticles and their potential cytotoxic activity against cancer cell lines

Prasannaraj

Venkatachalam

2017

Adv. Nat. Sci: Nanosci. Nanotechnol.

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“…Similar results were also reported by Gardea-Torresdey et al [32] and Vijayakumar et al [33]. Recently Jeeva et al [22] obtained AgNPs with spherical shape showing strong absorption spectra in the range of 2.5-4 keV by using C. coriaria leaf extracts and Bhuvaneswari et al [18] also noticed spherical shape metallic silver nanocrystals that showed strong absorption peak in the range of 2.5-4 keV using N. crenulata leaf extracts. The strong spectrum signals were likely to be due to the X-ray emission from active biomolecules available in the plant extracts [22,34].…”

Section: Fesem and Edax Analysissupporting

confidence: 75%

“…Results confirmed that the reduction of AgNO 3 did not occur under the reaction conditions. Similar results were also demonstrated recently [18,21,22]. It is well recognized that the optical absorption peak of metal nanoparticles was dominated by surface plasmon resonances (SPRs) that shift to longer wavelengths with increasing particle size due to the capping agent [23,24].…”

Section: Uv-vissupporting

confidence: 71%

“…Earlier reports have described the effect of crude plant extracts on wound healing activity [17]. Most recently, Bhuvaneswari et al [18] described a method for synthesis of bioactive compound loaded stable silver nanoparticles from aqueous leaf extracts of Naringi crenulata and studied its wound healing activity in experimental rat model. Although different medicinal plant extracts as well as nanoparticles have been tried for the wound healing treatment in the recent past, there were no reports on wound healing activity using either crude extracts or the silver nanoparticles synthesized using Cucumis sativus plant extracts so far.…”

Section: Journal Of Nanomaterialsmentioning

confidence: 99%

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Phytofabrication of Bioactive Molecules Encapsulated Metallic Silver Nanoparticles from Cucumis sativus L. and Its Enhanced Wound Healing Potential in Rat Model

Venkatachalam

Sangeetha

Geetha

et al. 2015

Journal of Nanomaterials

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The present study describes a rapid method for synthesis of metallic silver nanoparticles using callus (CAgNPs) and leaf extracts (LEAgNPs) of Cucumis sativus and evaluation of its wound healing activity in rat model. The prepared silver nanoparticles showed a peak at 350 nm corresponding to the surface plasmon resonance band. The FTIR spectroscopy measurements showed the presence of the possible biomolecules. X-ray diffraction analysis confirmed the crystalline structure of the synthesized silver nanoparticles. TEM images showed the size of the synthesized CAgNPs with diameter ranged from 21 nm to 23 nm with polygonal shape whereas, in the case of LEAgNPs, spherical shape was noticed with an average size between 11 nm and 19 nm. The EDX results indicated the chemical composition at specific locations on synthesized nanoparticles. Furthermore the topical application of ointment prepared using synthesized AgNPs was found to show enhanced wound healing activity in Wistar albino rat model. By the 21st day, the ointment base containing 5% (w/w) of silver nanoparticles showed 100% potential wound healing activity than the standard drug as well as control bases. Results strongly showed that the ointment base containing LEAgNPs was found to be very effective in wound repair mechanism in the experimental rats.

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“…O-H stretching shows peak at 3431 cm -1 . A peak at 2422 cm -1 corresponds to aldehydic C-H stretching; weaker band at 1667 cm -1 is ascribed to ketone and ester group [27,28]. The peak at 1520 cm -1 corresponds to germinal methyl group and a peak near 1120 cm -1 is assigned to C-N stretching vibrations [29].…”

Section: Conjugation Of Aunps With Activated Fa and Chlmentioning

confidence: 99%

Conjugation of Au Nanoparticles with Chlorambucil for Improved Anticancer Activity

et al. 2016

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Gold nanoparticles (AuNPs) of 30-40 nm in size has been prepared using A. hirsutus leaves extract as reducing agent for Au 3? ions under microwave irradiation from 60 to 360 s. These biocapped AuNPs were effectively conjugated with activated folic acid (FA, receptor) and chlorambucil (CHL, anticancer drug) molecules. The formation of AuNPs-FA-CHL was confirmed from different characterization techniques such as XRD, UV-Visible spectra, FT-IR and TEM images. The anticancer activity of these bioconjugated AuNPs was tested against human cancer cell lines (HeLa, RKO and A549) in comparison with normal epithelial cells (Vero). Unlike AuNPs and CHL alone, AuNPs-FA-CHL showed high toxicity towards human cancer cells by significantly decreasing the percentage viability of cells. Furthermore, the amount of drug released was found to be maximum at an ideal tumor environment pH 5.3.

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Bioactive compound loaded stable silver nanoparticle synthesis from microwave irradiated aqueous extracellular leaf extracts of Naringi crenulata and its wound healing activity in experimental rat model

Cited by 52 publications

References 40 publications

Green engineering of biomolecule-coated metallic silver nanoparticles and their potential cytotoxic activity against cancer cell lines

Green engineering of biomolecule-coated metallic silver nanoparticles and their potential cytotoxic activity against cancer cell lines

Phytofabrication of Bioactive Molecules Encapsulated Metallic Silver Nanoparticles from Cucumis sativus L. and Its Enhanced Wound Healing Potential in Rat Model

Conjugation of Au Nanoparticles with Chlorambucil for Improved Anticancer Activity

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